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Protein Overview: SPBC2G2.12

General Information:
Name(s) found: SPBC2G2.12 [Sanger Pombe]
Description(s) found:
Found 17 descriptions.
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  • histidine-tRNA ligase [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 538 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [ISSLink to PubMed article]
    mitochondrion [ISSLink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: histidyl-tRNA aminoacylation [ISSLink to PubMed article]
    mitochondrial translation [RCALink to PubMed article]
    Molecular Function: histidine-tRNA ligase activity [ISSLink to PubMed article]
    ATP binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADSLVDINE RITSQGNLVR SLKSQGASKE DIDKEVAKLL QLKNLKLGGS EVSGKKKDTS  60
   61 FTLKTPKGTK DWCDKDVVLR EHIFSTVTEI FKRHGGVTLD TPVFELKEIL SGKYGEDSKL 120
  121 IYDLKDQGGE LCSLRYDLTV PFARWLAMNP KVTSIKRFHI AKVYRRDQPA MTKGRMREFY 180
  181 QCDFDIAGNY DPMIPDSEAL KVLVEALDAL EVGNYTIKLN HRKILDGIFT VCGVPDDKIR 240
  241 TISSAVDKLD KLPWEDVRRE MVVEKGLKEE VADKIKEYVL LKGDRSLLDK LEADSLLSSN 300
  301 SSAVAAFNDM RLLFDYLEAF GVLDRFSFDM SLARGLDYYT GIIYEAVTEA SAPKIKSSAE 360
  361 KKKSADPEAD RSNDDSIGVG SIAAGGRYDN LVGMFAAKKN AKIPCVGISL GLERIFSILR 420
  421 SKIPDEDIRA NDVDVFVMAF GGGKEWTGFL KERMSVCKDL WANGIKAEFL YKVKPKPRQQ 480
  481 FDAADKFDVP FAVILGQDEF AKGSVRIKQM GLKENSDEGQ LVPREEMVSV LKKLLKYD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..61] PSI-BLAST 33.69897 Lysyl-tRNA synthetase (LysRS)
    2 View Details [62..538] PSI-BLAST 47.69897 Histidyl-tRNA synthetase (HisRS), C-terminal domain; Histidyl-tRNA synthetase (HisRS)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  7.89468709683036 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  7.89468709683036 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  7.88410036819636 bayes_pls_golite062009
  • ligase activity
    		•  6.92073480193262 bayes_pls_golite062009
  • histidine-tRNA ligase activity
    		•  5.91343220471745 bayes_pls_golite062009
  • phenylalanine-tRNA ligase activity
    		•  2.99105702052936 bayes_pls_golite062009
  • serine-tRNA ligase activity
    		•  2.46505535069103 bayes_pls_golite062009
  • glycine-tRNA ligase activity
    		•  2.29229136935761 bayes_pls_golite062009
  • threonine-tRNA ligase activity
    		•  2.18642354927 bayes_pls_golite062009
  • catalytic activity
    		•  1.99372273395202 bayes_pls_golite062009
  • alanine-tRNA ligase activity
    		•  1.82594054955281 bayes_pls_golite062009
  • lysine-tRNA ligase activity
    		•  1.72324031407565 bayes_pls_golite062009
  • asparagine-tRNA ligase activity
    		•  0.921492123574877 bayes_pls_golite062009
  • binding
    		•  0.916222310895772 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.375542987753806 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.281662799812287 bayes_pls_golite062009
  • DNA binding
    		•  0.0309732052586011 bayes_pls_golite062009
  • aspartate-tRNA ligase activity
    		•  0.00572514744734753 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle