YRC Public Data Repository - Protein Structure Prediction

Protein:	SPBC2G2.12
Organism:	Schizosaccharomyces pombe
Length:	538 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPBC2G2.12.

Description	E-value	Query Range	Subject Range
gi\|90408309, gi\|... - gi\|90408309\|ref\|ZP_01216474.1\| prolyl-tRNA synthetase [Psychromonas sp. CNPT3], gi\|90310610\|gb\|EAS38...	270.0	[0..39]	[536..8]
SYP_SHEPC - Proline--tRNA ligase OS=Shewanella putrefaciens (strain CN-32 / ATCC BAA-453) GN=proS PE=3 SV=1	267.0	[0..39]	[537..8]
SYP_SHESW - Proline--tRNA ligase OS=Shewanella sp. (strain W3-18-1) GN=proS PE=3 SV=1	266.0	[0..39]	[537..8]
gi\|16759234 - gi\|16759234\|ref\|NP_454851.1\| prolyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar Typ... SYP_SALPA - Proline--tRNA ligase OS=Salmonella paratyphi A GN=proS PE=3 SV=1 SYP_SALTI - Prolyl-tRNA synthetase OS=Salmonella typhi GN=proS PE=3 SV=1 SYP_SALTY - Prolyl-tRNA synthetase OS=Salmonella typhimurium GN=proS PE=3 SV=1 SYP_SALPB - Proline--tRNA ligase OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=proS PE=3 SV=1 SYP_SALPA - Proline--tRNA ligase OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) GN=proS PE=3 SV=1 SYP_SALTY - Proline--tRNA ligase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=proS PE=3 SV... gi\|29140783, gi\|... - gi\|29140783\|ref\|NP_804125.1\| prolyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar Typ... SYP_SALTI - Proline--tRNA ligase OS=Salmonella typhi GN=proS PE=3 SV=1 SYP_SALEP - Proline--tRNA ligase OS=Salmonella enteritidis PT4 (strain P125109) GN=proS PE=3 SV=1 SYP_SALG2 - Proline--tRNA ligase OS=Salmonella gallinarum (strain 287/91 / NCTC 13346) GN=proS PE=3 SV=1 gi\|213428490 - gi\|213428490\|ref\|ZP_03361240.1\| prolyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar ... gi\|213051828 - gi\|213051828\|ref\|ZP_03344706.1\| prolyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar ... SYP_SALPK - Proline--tRNA ligase OS=Salmonella paratyphi A (strain AKU_12601) GN=proS PE=3 SV=1 gi\|197264294, gi... - gi\|197264294\|ref\|ZP_03164368.1\| prolyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar ... gi\|200386929, gi... - gi\|200386929\|ref\|ZP_03213541.1\| prolyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar ... SYP_SALDC - Proline--tRNA ligase OS=Salmonella dublin (strain CT_02021853) GN=proS PE=3 SV=1 gi\|195632930, gi... - gi\|195632930\|gb\|EDX51384.1\| prolyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar Newp... gi\|205346928, gi... - gi\|205346928\|gb\|EDZ33559.1\| prolyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar Hada... gi\|194459187, gi... - gi\|194472823\|ref\|ZP_03078807.1\| prolyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar ... SYP_SALHS - Proline--tRNA ligase OS=Salmonella heidelberg (strain SL476) GN=proS PE=3 SV=1 gi\|167990131, gi... - gi\|205331403\|gb\|EDZ18167.1\| prolyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar 4,[5... gi\|168245012, gi... - gi\|205336220\|gb\|EDZ22984.1\| prolyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar Heid... gi\|205335202, gi... - gi\|205335202\|gb\|EDZ21966.1\| prolyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar Kent... lcl\|NC_016856.1_... - [gene=proS] [protein=prolyl-tRNA synthetase] [protein_id=YP_005235913.1] [location=complement(283167... gi\|213865222 - gi\|213865222\|ref\|ZP_03387341.1\| prolyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar ... SYP_SALPB - Prolyl-tRNA synthetase OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=proS PE=3 SV=1 gi\|213580835 - gi\|213580835\|ref\|ZP_03362661.1\| prolyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar ... SYP_SALTY - Proline--tRNA ligase OS=Salmonella typhimurium GN=proS PE=3 SV=1	265.0	[0..39]	[532..8]
gi\|189364925, gi... - gi\|189364925\|gb\|EDU83341.1\| prolyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4501], gi\|168765... gi\|13359652, gi\|... - gi\|15829450\|ref\|NP_308223.1\| prolyl-tRNA synthetase [Escherichia coli O157:H7 str. Sakai], gi\|133596... gi\|188013912, gi... - gi\|188013912\|gb\|EDU52034.1\| prolyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4113], gi\|168752... gi\|25293208, gi\|... - pir\|\|D85504 proline tRNA synthetase [imported] - Escherichia coli (strain O157:H7, substrain EDL933... gi\|189371068, gi... - gi\|189371068\|gb\|EDU89484.1\| prolyl-tRNA synthetase [Escherichia coli O157:H7 str. EC869], gi\|1687893... gi\|168782925, gi... - gi\|188999651\|gb\|EDU68637.1\| prolyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4076], gi\|168782... gi\|12512925, gi\|... - gi\|15799876\|ref\|NP_285888.1\| prolyl-tRNA synthetase [Escherichia coli O157:H7 EDL933], gi\|12512925\|g... gi\|187767123, gi... - gi\|187767123\|gb\|EDU30967.1\| prolyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4196], gi\|168777... SYP_ECO57 - Proline--tRNA ligase OS=Escherichia coli O157:H7 GN=proS PE=3 SV=1 gi\|189361055, gi... - gi\|189361055\|gb\|EDU79474.1\| prolyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4486], gi\|168769... gi\|208812619, gi... - gi\|208812619\|ref\|ZP_03253948.1\| prolyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4045], gi\|20... gi\|208729249, gi... - gi\|208809448\|ref\|ZP_03251785.1\| prolyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4206], gi\|20... gi\|195939891 - gi\|195939891\|ref\|ZP_03085273.1\| prolyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4024] gi\|168802460, gi... - gi\|189375548\|gb\|EDU93964.1\| prolyl-tRNA synthetase [Escherichia coli O157:H7 str. EC508], gi\|1688024... gi\|254590727, gi... - gi\|254791327\|ref\|YP_003076164.1\| prolyl-tRNA synthetase [Escherichia coli O157:H7 str. TW14359], gi\|... gi\|217320535, gi... - gi\|217324314\|ref\|ZP_03440398.1\| prolyl-tRNA synthetase [Escherichia coli O157:H7 str. TW14588], gi\|2... SYP_ECO5E - Proline--tRNA ligase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=proS PE=3 SV=1 gi\|208741291, gi... - gi\|208821168\|ref\|ZP_03261488.1\| prolyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4042], gi\|20...	264.0	[0..39]	[536..8]
SYP_SALCH - Proline--tRNA ligase OS=Salmonella choleraesuis (strain SC-B67) GN=proS PE=3 SV=2 SYP_SALCH - Proline--tRNA ligase OS=Salmonella choleraesuis GN=proS PE=3 SV=2 SYP_SALCH - Prolyl-tRNA synthetase OS=Salmonella choleraesuis GN=proS PE=3 SV=2	264.0	[0..39]	[532..8]
SYP_ECO24 - Proline--tRNA ligase OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=proS PE=3 SV=1	264.0	[0..39]	[536..8]
gi\|73949318 - gi\|73949318\|ref\|XP_535213.2\| PREDICTED: similar to Histidyl-tRNA synthetase (Histidine--tRNA ligase)...	264.0	[0..1]	[534..1]
SYP_SHEB9 - Proline--tRNA ligase OS=Shewanella baltica (strain OS195) GN=proS PE=3 SV=1	264.0	[0..39]	[536..8]
SYP_ECOK1 - Proline--tRNA ligase OS=Escherichia coli O1:K1 / APEC GN=proS PE=3 SV=1 SYP_ECOSM - Proline--tRNA ligase OS=Escherichia coli (strain SMS-3-5 / SECEC) GN=proS PE=3 SV=1 SYP_ECO27 - Proline--tRNA ligase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=proS PE=3 SV=1 SYP_ECOL6 - Proline--tRNA ligase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=proS PE=3 SV=... SYP_ECO45 - Proline--tRNA ligase OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=proS PE=3 SV=1 SYP_ECO81 - Proline--tRNA ligase OS=Escherichia coli O81 (strain ED1a) GN=proS PE=3 SV=1 sp\|B7UJ96\|SYP_ECO27 - Prolyl-tRNA synthetase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=proS PE=3 SV=1 SYP_ECOUT - Proline--tRNA ligase OS=Escherichia coli (strain UTI89 / UPEC) GN=proS PE=3 SV=2 SYP_ECOL5 - Proline--tRNA ligase OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=proS PE=3 SV=1 SYP_ECOL6 - Proline--tRNA ligase OS=Escherichia coli O6 GN=proS PE=3 SV=2 gi\|227884892, gi... - gi\|227884892\|ref\|ZP_04002697.1\| proline--tRNA ligase [Escherichia coli 83972], gi\|227838141\|gb\|EEJ48... gi\|190908349, gi... - gi\|75241739\|ref\|ZP_00725576.1\| COG0442: Prolyl-tRNA synthetase [Escherichia coli F11], gi\|191171415\|...	264.0	[0..39]	[532..8]

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Predicted Domain #1

Region A:
Residues: [1-61]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADSLVDINE RITSQGNLVR SLKSQGASKE DIDKEVAKLL QLKNLKLGGS EVSGKKKDTS  60
   61 F

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	33.69897
Match:	1e1oA
Description:	Lysyl-tRNA synthetase (LysRS)
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [62-538]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TLKTPKGTKD WCDKDVVLRE HIFSTVTEIF KRHGGVTLDT PVFELKEILS GKYGEDSKLI  60
   61 YDLKDQGGEL CSLRYDLTVP FARWLAMNPK VTSIKRFHIA KVYRRDQPAM TKGRMREFYQ 120
  121 CDFDIAGNYD PMIPDSEALK VLVEALDALE VGNYTIKLNH RKILDGIFTV CGVPDDKIRT 180
  181 ISSAVDKLDK LPWEDVRREM VVEKGLKEEV ADKIKEYVLL KGDRSLLDKL EADSLLSSNS 240
  241 SAVAAFNDMR LLFDYLEAFG VLDRFSFDMS LARGLDYYTG IIYEAVTEAS APKIKSSAEK 300
  301 KKSADPEADR SNDDSIGVGS IAAGGRYDNL VGMFAAKKNA KIPCVGISLG LERIFSILRS 360
  361 KIPDEDIRAN DVDVFVMAFG GGKEWTGFLK ERMSVCKDLW ANGIKAEFLY KVKPKPRQQF 420
  421 DAADKFDVPF AVILGQDEFA KGSVRIKQMG LKENSDEGQL VPREEMVSVL KKLLKYD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	47.69897
Match:	1httA
Description:	Histidyl-tRNA synthetase (HisRS), C-terminal domain; Histidyl-tRNA synthetase (HisRS)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ligase activity, forming aminoacyl-tRNA and related compounds	7.89468709683036	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	7.89468709683036	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	7.88410036819636	bayes_pls_golite062009
ligase activity	6.92073480193262	bayes_pls_golite062009
histidine-tRNA ligase activity	5.91343220471745	bayes_pls_golite062009
phenylalanine-tRNA ligase activity	2.99105702052936	bayes_pls_golite062009
serine-tRNA ligase activity	2.46505535069103	bayes_pls_golite062009
glycine-tRNA ligase activity	2.29229136935761	bayes_pls_golite062009
threonine-tRNA ligase activity	2.18642354927	bayes_pls_golite062009
catalytic activity	1.99372273395202	bayes_pls_golite062009
alanine-tRNA ligase activity	1.82594054955281	bayes_pls_golite062009
lysine-tRNA ligase activity	1.72324031407565	bayes_pls_golite062009
asparagine-tRNA ligase activity	0.921492123574877	bayes_pls_golite062009
binding	0.916222310895772	bayes_pls_golite062009
transcription regulator activity	0.375542987753806	bayes_pls_golite062009
nucleic acid binding	0.281662799812287	bayes_pls_golite062009
DNA binding	0.0309732052586011	bayes_pls_golite062009
aspartate-tRNA ligase activity	0.00572514744734753	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: