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Protein Overview: apn2

General Information:
Name(s) found: apn2 / SPBC3D6.10 [Sanger Pombe]
Description(s) found:
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  • gi|7490480|pir||T40370 dna-(apurinic or apyrimidinic site) lyase - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|48427993|sp|P87175.1|APN2_SCHPO RecName: Full=DNA-(apurinic or apyrimidinic site) lyase 2; AltName: Full=AP endonuclease 2; AltName: Full=Apurinic-apyrimidinic endonuclease 2 [NCBI NR]
  • gi|40287246|gb|AAR83752.1| AP-endonuclease-like protein [Schizosaccharomyces pombe] [NCBI NR]
  • gi|2117306|emb|CAB09119.1| AP-endonuclease Apn2 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19112314|ref|NP_595522.1| AP-endonuclease Apn2 [Schizosaccharomyces pombe] [NCBI NR]
  • AP-endonuclease Apn2 [Sanger Pombe]
  • DNA-(apurinic or apyrimidinic site) lyase 2 OS=Schizosaccharomyces pombe GN=apn2 PE=1 SV=1 [Swiss-Prot]
  • DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE: P87175; [pompepVF.fasta]
  • DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) [pompep4896]
  • |||putative DNA lyase-(apurinic or apyrimidinic site) [pompepnew.fasta]
  • DNA-(apurinic or apyrimidinic site) lyase 2 (EC 4.2.99.18) (AP endonuclease 2) (Apurinic-apyrimidinic endonuclease 2) [4896.FASTAC]
  • |apn2||DNA-(apurinic or apyrimidinic site) lyase activity (predicted)|Schizosaccharomyces pombe|chr 2|||Manual [pombe041504.fasta]
  • dna-(apurinic or apyrimidinic site) lyase [Schizosaccharomyces pombe]gi|48427993|sp|P87175|APN2_SCHPO DNA-(apurinic or apyrimidinic site) lyase 2 (AP endonuclease 2) (Apurinic-apyrimidinic endonuclease 2)gi|7490480|pir||T40370 dna-(apurinic or apyrimidi [nrdb_11152004_Chlamydomonas]
  • |apn2||DNA-|Schizosaccharomyces pombe|chr 2|||Manual [pompep2242005.fasta]
  • (P87175) DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) [pompep4896_normal_reversed]
  • |apn2||AP-endonuclease Apn2|Schizosaccharomyces pombe|chr 2|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • DNA-(apurinic or apyrimidinic site) lyase 2 (AP endonuclease 2) (Apurinic-apyrimidinic endonuclease 2) [nr-271106-contam.fasta]
  • DNA-(apurinic or apyrimidinic) lyase [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • AP-endonuclease-like protein [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • SPBC3D6.10 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • DNA-(apurinic or apyrimidinic site) lyase 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=apn2 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 523 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: base-excision repair [ICLink to PubMed article]
    cellular response to reactive oxygen species [IMPLink to PubMed article]
    Molecular Function: DNA binding [IEA]
    phosphodiesterase I activity [ISSLink to PubMed article]
    endonuclease activity [IEA]
    double-stranded DNA specific 3'-5' exodeoxyribonuclease activity [IMPLink to PubMed article]
    DNA-(apurinic or apyrimidinic site) lyase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRILSWNVNG IQNPFNYFPW NKKNSYKEIF QELQADVICV QELKMQKDSF PQQYAVVEGF  60
   61 DSYFTFPKIR KGYSGVGFYV KKDVAIPVKA EEGITGILPV RGQKYSYSEA PEHEKIGFFP 120
  121 KDIDRKTANW IDSEGRCILL DFQMFILIGV YCPVNSGENR LEYRRAFYKA LRERIERLIK 180
  181 EGNRKIILVG DVNILCNPID TADQKDIIRE SLIPSIMESR QWIRDLLLPS RLGLLLDIGR 240
  241 IQHPTRKGMF TCWNTRLNTR PTNYGTRIDY TLATPDLLPW VQDADIMAEV MGSDHCPVYL 300
  301 DLKEEYEGKK LSNFLSHSKE PPLLSTAHHS AYRPSKNIHS MFQHFNSMKK NKNNSPTQSE 360
  361 NVSASASSGS SPTVSRANSV IDVDAYPPEK RRRKEQSKLL SFFAKQKEEK EETNKTEDVS 420
  421 IEVLDNNNES DIGLTVKKKV ENGNAWKQIF SERAPPLCEG HKEPCKYLTV RKPGINYGRK 480
  481 FWICARPVGE LIKNSNAVSE EDTQPFQCRF FIWDSDWRAN SKD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..305] PSI-BLAST 54.69897 DNA repair endonuclease Hap1
    2 View Details [306..523] MSA 11.172993 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • hydrolase activity
    		•  3.39868193112836 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  3.04161110413795 bayes_pls_golite062009
  • exonuclease activity
    		•  2.70644978530491 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  2.57658637220545 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  2.54419310609558 bayes_pls_golite062009
  • exodeoxyribonuclease activity
    		•  1.8139951607534 bayes_pls_golite062009
  • exodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  1.7967853371745 bayes_pls_golite062009
  • nuclease activity
    		•  1.78432551160775 bayes_pls_golite062009
  • catalytic activity
    		•  1.76511376991978 bayes_pls_golite062009
  • binding
    		•  1.74593496417303 bayes_pls_golite062009
  • DNA binding
    		•  0.961734136090079 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.947430734766989 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.597390739522692 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.58571720340663 bayes_pls_golite062009
  • transcription factor binding
    		•  0.55477888309075 bayes_pls_golite062009
  • phosphodiesterase I activity
    		•  0.541624633849381 bayes_pls_golite062009
  • protein binding
    		•  0.476649214025345 bayes_pls_golite062009
  • endonuclease activity
    		•  0.288539805949629 bayes_pls_golite062009
  • inositol or phosphatidylinositol phosphatase activity
    		•  0.228910502815798 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  0.100365481550461 bayes_pls_golite062009
  • phosphatase activity
    		•  0.00559251346312178 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle