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View Structure Prediction Details

Protein: apn2
Organism: Schizosaccharomyces pombe
Length: 523 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for apn2.

Description E-value Query
Range
Subject
Range
gi|16904254 - gi|16904254|gb|AAL30835.1|AF440398_3 DNA lyase-like protein [Mycosphaerella graminicola]
353.0 [0..1] [520..1]
gi|29501198 - gi|29501198|dbj|BAC67542.1| DNA lyase [Isaria tenuipes]
350.0 [0..11] [521..5]
gi|29420515 - gi|29420515|dbj|BAC66501.1| DNA lyase [Cordyceps militaris]
336.0 [0..10] [521..4]
gi|26341548, gi|... - gi|26341548|dbj|BAC34436.1| unnamed protein product [Mus musculus], gi|22830557|dbj|BAC11807.1| apur...
333.0 [0..1] [514..2]
gi|120586985, gi... - gi|149031345|gb|EDL86343.1| rCG38932, isoform CRA_a [Rattus norvegicus], gi|120586985|ref|NP_0010733...
330.0 [0..1] [514..2]
gi|169595280, gi... - gi|169595280|ref|XP_001791064.1| hypothetical protein SNOG_00377 [Phaeosphaeria nodorum SN15], gi|11...
326.0 [0..2] [519..3]

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Predicted Domain #1
Region A:
Residues: [1-305]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRILSWNVNG IQNPFNYFPW NKKNSYKEIF QELQADVICV QELKMQKDSF PQQYAVVEGF  60
   61 DSYFTFPKIR KGYSGVGFYV KKDVAIPVKA EEGITGILPV RGQKYSYSEA PEHEKIGFFP 120
  121 KDIDRKTANW IDSEGRCILL DFQMFILIGV YCPVNSGENR LEYRRAFYKA LRERIERLIK 180
  181 EGNRKIILVG DVNILCNPID TADQKDIIRE SLIPSIMESR QWIRDLLLPS RLGLLLDIGR 240
  241 IQHPTRKGMF TCWNTRLNTR PTNYGTRIDY TLATPDLLPW VQDADIMAEV MGSDHCPVYL 300
  301 DLKEE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 54.69897
Match: 1e9nA
Description: DNA repair endonuclease Hap1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydrolase activity 3.39868193112836 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 3.04161110413795 bayes_pls_golite062009
exonuclease activity 2.70644978530491 bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2.57658637220545 bayes_pls_golite062009
deoxyribonuclease activity 2.54419310609558 bayes_pls_golite062009
exodeoxyribonuclease activity 1.8139951607534 bayes_pls_golite062009
exodeoxyribonuclease activity, producing 5'-phosphomonoesters 1.7967853371745 bayes_pls_golite062009
nuclease activity 1.78432551160775 bayes_pls_golite062009
catalytic activity 1.76511376991978 bayes_pls_golite062009
binding 1.74593496417303 bayes_pls_golite062009
DNA binding 0.961734136090079 bayes_pls_golite062009
nucleic acid binding 0.947430734766989 bayes_pls_golite062009
transcription regulator activity 0.597390739522692 bayes_pls_golite062009
transcription coactivator activity 0.58571720340663 bayes_pls_golite062009
transcription factor binding 0.55477888309075 bayes_pls_golite062009
phosphodiesterase I activity 0.541624633849381 bayes_pls_golite062009
protein binding 0.476649214025345 bayes_pls_golite062009
endonuclease activity 0.288539805949629 bayes_pls_golite062009
inositol or phosphatidylinositol phosphatase activity 0.228910502815798 bayes_pls_golite062009
phosphoric ester hydrolase activity 0.100365481550461 bayes_pls_golite062009
phosphatase activity 0.00559251346312178 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [306-523]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YEGKKLSNFL SHSKEPPLLS TAHHSAYRPS KNIHSMFQHF NSMKKNKNNS PTQSENVSAS  60
   61 ASSGSSPTVS RANSVIDVDA YPPEKRRRKE QSKLLSFFAK QKEEKEETNK TEDVSIEVLD 120
  121 NNNESDIGLT VKKKVENGNA WKQIFSERAP PLCEGHKEPC KYLTVRKPGI NYGRKFWICA 180
  181 RPVGELIKNS NAVSEEDTQP FQCRFFIWDS DWRANSKD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle