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Protein Overview: vps27

General Information:
Name(s) found: vps27 / SPAC19A8.05c [Sanger Pombe]
Description(s) found:
Found 17 descriptions.
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  • sorting receptor for ubiquitinated membrane proteins, ESCRT 0 complex [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 610 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    prospore membrane [IDALink to PubMed article]
    ESCRT-0 complex [IPILink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: protein retention in Golgi apparatus [ISSLink to PubMed article]
    protein targeting to vacuole during ubiquitin-dependent protein catabolic process via the MVB pathway [IMPLink to PubMed article]
    late endosome to vacuole transport [IMPLink to PubMed article]
    ascospore-type prospore formation [IGILink to PubMed article]
    endocytosis [IMPLink to PubMed article]
    Molecular Function: zinc ion binding [IEA]
    ubiquitin binding [IMPLink to PubMed article]
    phosphoinositide binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRWWNSNSQ FASDIEKATS ETLPAGSEEI SLYLEISDQI RSKSVDPKFA MRILKSRIDH  60
   61 SNPNVQIMAL KLTDTCVKNG GSGFLLEIAS REFMDNLVSI LRSPAGIDED VKMVILRYIQ 120
  121 SWALAVPDTN SPLSYIIHVY QNLKDGDYEF PEPSQNITSK FLDTETPPDW TDSEVCLRCR 180
  181 TPFTFTNRKH HCRNCGGVFC NQCSSKTLSL PHLGINQPVR VCDSCYSLRT KPKGSKSRAR 240
  241 NERKFHAKTR KTPSKPVTNN EDEDIKRAIE LSLKEMPQSR EPPSYERPSE ANVVISQDQH 300
  301 LTEDEDEELK RAIAISLEEA QKSSQKDDNV TAPNNMNISY PSVPAHTVST DIRSSPFSGR 360
  361 PSDNPSTLIS TADADNITLY ATLVQKLKKL PPGSIFTEYQ LQELHENMGV MRTRMMRSLG 420
  421 ETMSKYNGLI QALQKLQTCM RLNDALIEQR LSSTYAHHYI DSSMDSNRSI EPEPDVISTV 480
  481 RNSSTIPQAS SSSVPKIVVD SSPVTENPPS HSDVMGQKDT ISSYYSTDTD VSANVMGNRH 540
  541 DEVVFSDTAS GEKNTKLNID ESTNYYNTDS IDKVGEPFDE ISSGYDDLMN GNDKQGNDIP 600
  601 EVQEASLIEL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..238] PSI-BLAST 49.045757 Hrs
    2 View Details [239..335] FFAS03 3.38 Solution Structure of Tandem UIMs of Vps27
    3 View Details [336..458] PSI-BLAST 13.0 No description for 2pjwV was found.
    4 View Details [459..610] MSA 2.114996 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.73567588815578 bayes_pls_golite062009
  • clathrin binding
    		•  2.70535896247543 bayes_pls_golite062009
  • phosphoinositide binding
    		•  1.5307798253901 bayes_pls_golite062009
  • phospholipid binding
    		•  1.34712325037196 bayes_pls_golite062009
  • transporter activity
    		•  1.32696426532114 bayes_pls_golite062009
  • protein binding
    		•  1.32366404206022 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.01735624308761 bayes_pls_golite062009
  • protein transporter activity
    		•  1.0075677188289 bayes_pls_golite062009
  • DNA binding
    		•  0.896491359501813 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.850897491544184 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.694289284736477 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.679696382592776 bayes_pls_golite062009
  • phosphatidylinositol binding
    		•  0.67214549237381 bayes_pls_golite062009
  • hydrolase activity
    		•  0.570569488711945 bayes_pls_golite062009
  • histone binding
    		•  0.49822123308392 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0943698557209078 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0545685184292493 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0449648841896718 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.04237887650281 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle