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View Structure Prediction Details

Protein: vps27
Organism: Schizosaccharomyces pombe
Length: 610 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for vps27.

Description E-value Query
Range
Subject
Range
gi|50745477 - gi|50745477|ref|XP_426233.1| PREDICTED: similar to HGF-regulated tyrosine kinase substrate [Gallus g...
354.0 [0..4] [558..1]
gi|42548104, gi|... - gi|46128335|ref|XP_388721.1| hypothetical protein FG08545.1 [Gibberella zeae PH-1], gi|42548104|gb|E...
331.0 [0..1] [546..1]
gi|148225596, gi... - gi|38197319|gb|AAH61687.1| MGC68804 protein [Xenopus laevis], gi|148225596|ref|NP_001083588.1| hypot...
329.0 [0..4] [556..1]
VPS27_NEUCR - Vacuolar protein sorting-associated protein 27 OS=Neurospora crassa GN=vps-27 PE=3 SV=2
VPS27_NEUCR - Vacuolar protein sorting-associated protein 27 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A ...
326.0 [0..1] [501..1]
gi|109119088 - gi|109119088|ref|XP_001111673.1| PREDICTED: similar to hepatocyte growth factor-regulated tyrosine k...
322.0 [0..4] [556..1]
gi|74151293 - gi|74151293|dbj|BAE38778.1| unnamed protein product [Mus musculus]
322.0 [0..4] [556..1]
gi|73964685 - gi|73964685|ref|XP_855919.1| PREDICTED: similar to hepatocyte growth factor-regulated tyrosine kinas...
321.0 [0..4] [556..1]
gi|32879849, gi|... - gi|60653975|gb|AAX29680.1| hepatocyte growth factor-regulated tyrosine kinase substrate [synthetic c...
320.0 [0..4] [556..1]
gi|54035554, gi|... - gi|77539444|ref|NP_062260.2| hepatocyte growth factor-regulated tyrosine kinase substrate [Rattus no...
320.0 [0..4] [556..1]

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Predicted Domain #1
Region A:
Residues: [1-238]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRWWNSNSQ FASDIEKATS ETLPAGSEEI SLYLEISDQI RSKSVDPKFA MRILKSRIDH  60
   61 SNPNVQIMAL KLTDTCVKNG GSGFLLEIAS REFMDNLVSI LRSPAGIDED VKMVILRYIQ 120
  121 SWALAVPDTN SPLSYIIHVY QNLKDGDYEF PEPSQNITSK FLDTETPPDW TDSEVCLRCR 180
  181 TPFTFTNRKH HCRNCGGVFC NQCSSKTLSL PHLGINQPVR VCDSCYSLRT KPKGSKSR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 49.045757
Match: 1dvpA
Description: Hrs
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.73567588815578 bayes_pls_golite062009
clathrin binding 2.70535896247543 bayes_pls_golite062009
phosphoinositide binding 1.5307798253901 bayes_pls_golite062009
phospholipid binding 1.34712325037196 bayes_pls_golite062009
transporter activity 1.32696426532114 bayes_pls_golite062009
protein binding 1.32366404206022 bayes_pls_golite062009
nucleic acid binding 1.01735624308761 bayes_pls_golite062009
protein transporter activity 1.0075677188289 bayes_pls_golite062009
DNA binding 0.896491359501813 bayes_pls_golite062009
transcription regulator activity 0.850897491544184 bayes_pls_golite062009
small conjugating protein ligase activity 0.694289284736477 bayes_pls_golite062009
substrate-specific transporter activity 0.679696382592776 bayes_pls_golite062009
phosphatidylinositol binding 0.67214549237381 bayes_pls_golite062009
hydrolase activity 0.570569488711945 bayes_pls_golite062009
histone binding 0.49822123308392 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0943698557209078 bayes_pls_golite062009
pyrophosphatase activity 0.0545685184292493 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.0449648841896718 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.04237887650281 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [239-335]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ARNERKFHAK TRKTPSKPVT NNEDEDIKRA IELSLKEMPQ SREPPSYERP SEANVVISQD  60
   61 QHLTEDEDEE LKRAIAISLE EAQKSSQKDD NVTAPNN

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.38
Match: 1q0vA
Description: Solution Structure of Tandem UIMs of Vps27
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [336-458]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNISYPSVPA HTVSTDIRSS PFSGRPSDNP STLISTADAD NITLYATLVQ KLKKLPPGSI  60
   61 FTEYQLQELH ENMGVMRTRM MRSLGETMSK YNGLIQALQK LQTCMRLNDA LIEQRLSSTY 120
  121 AHH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.0
Match: 2pjwV
Description: No description for 2pjwV was found.

Predicted Domain #4
Region A:
Residues: [459-610]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YIDSSMDSNR SIEPEPDVIS TVRNSSTIPQ ASSSSVPKIV VDSSPVTENP PSHSDVMGQK  60
   61 DTISSYYSTD TDVSANVMGN RHDEVVFSDT ASGEKNTKLN IDESTNYYNT DSIDKVGEPF 120
  121 DEISSGYDDL MNGNDKQGND IPEVQEASLI EL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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