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Protein Overview: pku80

General Information:
Name(s) found: pku80 / SPBC543.03c [Sanger Pombe]
Description(s) found:
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  • gi|9929270|emb|CAC05245.1| Ku domain protein Pku80 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|74624850|sp|Q9HGM8.1|KU80_SCHPO RecName: Full=ATP-dependent DNA helicase II subunit 2; AltName: Full=ATP-dependent DNA helicase II subunit Ku80; AltName: Full=Pombe Ku80 [NCBI NR]
  • gi|19113583|ref|NP_596791.1| Ku domain protein Pku80 [Schizosaccharomyces pombe] [NCBI NR]
  • Ku domain protein Pku80 [Sanger Pombe]
  • ATP-dependent DNA helicase II subunit 2 OS=Schizosaccharomyces pombe GN=pku80 PE=1 SV=1 [Swiss-Prot]
  • PUTATIVE DNA HELICASE: Q9HGM8; [pompepVF.fasta]
  • Putative DNA helicase [pompep4896]
  • |||putative DNA helicase [pompepnew.fasta]
  • SPBC543.03c protein [4896.FASTAC]
  • |pku80||Ku domain protein|Schizosaccharomyces pombe|chr 2|||Manual [pombe041504.fasta]
  • putative DNA helicase [Schizosaccharomyces pombe]gi|9929270|emb|CAC05245.1| SPBC543.03c [Schizosaccharomyces pombe] [nrdb_11152004_Chlamydomonas]
  • (Q9HGM8) Putative DNA helicase [pompep4896_normal_reversed]
  • |pku80||Ku domain protein Pku80|Schizosaccharomyces pombe|chr 2|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • hypothetical protein SPBC543.03c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • SPBC543.03c [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • ATP-dependent DNA helicase II subunit 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=pku80 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 695 amino acids

    Gene Ontology:
    Cellular Component: chromosome, telomeric region [IDALink to PubMed article]
    nucleus [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: S phase of mitotic cell cycle [IMPLink to PubMed article]
    telomere maintenance [IMPLink to PubMed articleLink to PubMed article]
    double-strand break repair via nonhomologous end joining [IMPLink to PubMed article]
    Molecular Function: ATP binding [IEA]
    telomeric DNA binding [IDALink to PubMed article]
    protein heterodimerization activity [ISSLink to PubMed article]
    ATP-dependent DNA helicase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDKECTVFV LDLGKDMGTC HHGRSHSDLE WTLSYFHDEL SHKFLANRKT DVVGIVGYKC  60
   61 DDTKNDLAEQ EAYWNISVLY PIQTALFSKL QSVSQTLKPS NTMQGDLISA IVVSFDLMAR 120
  121 HCKKNKWKKK MIVLTAARGI IDFSDYIGIA EQLLQHDVFL GVYGVDFDQE DINYSEPLKE 180
  181 SQKKENEVRI QEFVESCHGQ YCTFQQIYNN IGKPWVRKVR PVAIFRGTFS IGNRDSKDTS 240
  241 ISIQVERYPR TRLTKPPTSS AFYENDMSKN YECLNIENSN VENKSMESDA VSTVRSYMVR 300
  301 DPKTNDSFEV KREDLESGYS YGRTIVPISR SDEDVLALDT IPGYEILGFI PKSSLPIYYT 360
  361 ISDTNIIVPK DDFESKLNFS AFVQSLEREH RYALARFVSK DKGVPVLLVL MPYVEFKRHY 420
  421 LVDIQLPFAE DVRPYSFSEF EKLSNEEDMR QIDFAVSNYI DNMDLDSSDC GFNPPFEPEN 480
  481 TFSMIPHRLQ QAISYYANSP EGDLPQPNIY LTRYTNPPKS LLDNCILDLK LIKEKLTVNV 540
  541 PVKPKYSSQE TAFDTGAPIS EEQIEELLNS GLDEQEGEKL LVLHVSEKDP VGTFTEVLKN 600
  601 PFGLEDALTE MEKVIKNLID KSKYDLALQS LQSLRLHSIL EDEVERFNEY LTRLKKDVMQ 660
  661 NNKPKENELI NKIRSSGLDI ILHDELTRHD NFNNI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..558] PSI-BLAST 119.0 Ku80 subunit
    2 View Details [559..695] PSI-BLAST 35.0 Three-dimensional structure of Ku80 CTD

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • double-stranded telomeric DNA binding
    		•  8.64621483095491 bayes_pls_golite062009
  • telomeric DNA binding
    		•  5.16364366157397 bayes_pls_golite062009
  • binding
    		•  2.55976325410124 bayes_pls_golite062009
  • protein binding
    		•  1.4332924081006 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.25153438703239 bayes_pls_golite062009
  • promoter binding
    		•  1.24066744801055 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.985753648509262 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.814975395718076 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.720743494912414 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.655463239522058 bayes_pls_golite062009
  • transcription activator activity
    		•  0.53035927712834 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.506640285146188 bayes_pls_golite062009
  • DNA binding
    		•  0.496246846559375 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.450760554291027 bayes_pls_golite062009
  • protein complex binding
    		•  0.31789779419928 bayes_pls_golite062009
  • protein C-terminus binding
    		•  0.15516806759612 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle