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Protein Overview: pik1

General Information:
Name(s) found: pik1 / SPAC22E12.16c [Sanger Pombe]
Description(s) found:
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  • gi|7492811|pir||T38173 probable phosphatidylinositol 4-kinase - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|238836734|gb|ACR61542.1| Pik1 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19115754|ref|NP_594842.1| phosphatidylinositol kinase Pik1 [Schizosaccharomyces pombe 972h-] [NCBI NR]
  • gi|1723526|sp|Q10366.1|YDBG_SCHPO RecName: Full=Uncharacterized PI3/PI4-kinase family protein C22E12.16c [NCBI NR]
  • gi|1220291|emb|CAA93903.1| phosphatidylinositol kinase Pik1 [Schizosaccharomyces pombe] [NCBI NR]
  • phosphatidylinositol kinase Pik1 [Sanger Pombe]
  • Uncharacterized PI3/PI4-kinase family protein C22E12.16c OS=Schizosaccharomyces pombe GN=SPAC22E12.16c PE=1 SV=1 [Swiss-Prot]
  • PUTATIVE PHOSPHATIDYLINOSITOL 4-KINASE: Q10366; [pompepVF.fasta]
  • Hypothetical protein C22E12.16c in chromosome I [pompep4896]
  • |||putative phosphatidylinositol 4-kinase [pompepnew.fasta]
  • |pik1||phosphatidylinositol kinase|Schizosaccharomyces pombe|chr 1|||Manual [pombe041504.fasta]
  • putative phosphatidylinositol 4-kinase [Schizosaccharomyces pombe]gi|1220291|emb|CAA93903.1| SPAC22E12.16c [Schizosaccharomyces pombe]gi|1723526|sp|Q10366|YDBG_SCHPO Hypothetical protein C22E12.16c in chromosome Igi|7492811|pir||T38173 probable phospha [nrdb_11152004_Chlamydomonas]
  • (Q10366) Hypothetical protein C22E12.16c in chromosome I [pompep4896_normal_reversed]
  • |pik1||phosphatidylinositol kinase Pik1|Schizosaccharomyces pombe|chr 1|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • hypothetical protein SPAC22E12.16c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • SPAC22E12.16c [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • Pik1 OS=Schizosaccharomyces pombe GN=pik1 PE=2 SV=1 [UniProt_SPombe_10-04-2010_reversed.fasta]
  • |pik1||1-phosphatidylinositol 4-kinase Pik1|Schizosaccharomyces pombe|chr 1|||Manual [Other_S_Pombe_12-15-2011_reversed.fasta]
    • Organism: Schizosaccharomyces pombe
    Length: 851 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISSLink to PubMed article]
    Golgi apparatus [IDALink to PubMed article][ISSLink to PubMed article]
    Biological Process: signal transduction [ISSLink to PubMed article]
    phosphoinositide-mediated signaling [IEA]
    phosphoinositide phosphorylation [ISSLink to PubMed article]
    phosphatidylinositol biosynthetic process [ISSLink to PubMed article]
    cellular protein localization [IGILink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article]
    1-phosphatidylinositol 4-kinase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPSSNSGNEL LLRFFESAHF TSQLCVAYLS RYPNNIGIHH FLCEKLATFP YEEIEFFIPQ  60
   61 LIHLVLNKDS ESVALEEFII SQCEQNTQCA LITFWYLQAH MVDLGLQPHS SCFKICKRLY 120
  121 NRIQILVFMS SSSLIQSQQK ISENVTPALI LSGIMLGGVC VPELLKKAGP IAIAQGRKAP 180
  181 RQDPDESDVD VLRRLSTEPR YSLDVLRSSL NNSIVEQHSE VSLRLKAPEL TRTHSYQSSA 240
  241 TLSIDEQRRV LRSNYFQQEI QFLFALQDIS IRLIIVPRQA RLSSLRAELA LLNNNLPADV 300
  301 NIPLLRSYHK EVSHKIVRID PKEATILNSA ERVPYLIMVE VLSGELSFEP QSKKNKAKVQ 360
  361 KIVSHKNQRK RWFDLTDVDP YTNLQDSTDN DISESESEGG DLSMSPLIKG LVPDTLSLSK 420
  421 SFSSFGNVSL QVPSSHRDTD VVLLSGRHSD SDGNGALKRS KIYASEITAR MRAAATMLSQ 480
  481 LDAEGSRRPK AETERIKNSI ILDMQRLEEE RLNEPSIYPV SVDISCAEDL RFGKETQKAE 540
  541 RKGDRDDPSA ATFQEDWYAK KERIRKSSPY GHYPNWDLVS VIVKTGADLR QETFACQLIY 600
  601 AFQRVWLECK EKVWVRRMKI LVTGDNSGLI ETITNAISVH SIKKNLTKQL REAELAQGKI 660
  661 AGKNVVTLKD YFIKQFGDPN SSRYRQAQTN FLQSLVAYSI ISYLLQLKDR HNGNVLIDSE 720
  721 GHIIHIDFGF LLTNTPGNVG FESAPFKLTA DYLEILDDRF DEYRSLMKAA FKSVRKNADQ 780
  781 IILLVEVMQN NSTMPCFRAG ENTSAQLLQR FQLQLGDKEC DDFVDLLIQK ANCSVWTRLY 840
  841 DLFQNITNGI Y

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..110] MSA 6.043979 View MSA. No confident structure predictions are available.
    2 View Details [111..851] PSI-BLAST 110.0 Phoshoinositide 3-kinase (PI3K) helical domain; Phoshoinositide 3-kinase (PI3K); Phoshoinositide 3-kinase (PI3K), catalytic domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • protein kinase activity
    		•  4.68131600649845 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  4.32184067232044 bayes_pls_golite062009
  • kinase activity
    		•  4.16135267871365 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  3.94110761715898 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  3.92556971928915 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • transferase activity
    		•  2.57136779276375 bayes_pls_golite062009
  • phosphoinositide 3-kinase activity
    		•  2.44230772088939 bayes_pls_golite062009
  • 1-phosphatidylinositol-3-kinase activity
    		•  2.31725772204126 bayes_pls_golite062009
  • clathrin binding
    		•  2.07672364145383 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.0371109148587 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  2.00935502502309 bayes_pls_golite062009
  • signal transducer activity
    		•  1.95775692939268 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.95775692939268 bayes_pls_golite062009
  • SNARE binding
    		•  1.90816272153996 bayes_pls_golite062009
  • calcium-dependent phospholipid binding
    		•  1.85892769686753 bayes_pls_golite062009
  • ATP binding
    		•  1.62950013799854 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.59120412984243 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.57251948653832 bayes_pls_golite062009
  • neurexin binding
    		•  1.37902741014529 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.32931505255952 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.32676572752438 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.31489723493061 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.3145826655017 bayes_pls_golite062009
  • nucleotide binding
    		•  1.31339663939554 bayes_pls_golite062009
  • syntaxin binding
    		•  1.29766799141407 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.27941426224024 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  1.27740808551012 bayes_pls_golite062009
  • protein binding
    		•  1.22565748038754 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • receptor activity
    		•  1.13726344123824 bayes_pls_golite062009
  • transporter activity
    		•  1.11833481501707 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.05231366895645 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.97575992765505 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.96468055729151 bayes_pls_golite062009
  • lipid kinase activity
    		•  0.74363752721495 bayes_pls_golite062009
  • phospholipase activity
    		•  0.689713182053935 bayes_pls_golite062009
  • protein transporter activity
    		•  0.662398920599074 bayes_pls_golite062009
  • nuclear localization sequence binding
    		•  0.611068932532731 bayes_pls_golite062009
  • phospholipase C activity
    		•  0.526467636680161 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.451090007290896 bayes_pls_golite062009
  • inositol or phosphatidylinositol kinase activity
    		•  0.328918574945998 bayes_pls_golite062009
  • signal sequence binding
    		•  0.27824906981293 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.252495966234234 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.205652638854091 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.185842548207239 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.134745748018448 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.00492507437049428 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle