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Protein Overview: ubp12

General Information:
Name(s) found: ubp12 / SPCC1494.05c [Sanger Pombe]
Description(s) found:
Found 19 descriptions.
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  • ubiquitin C-terminal hydrolase Ubp12 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 979 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article][TASLink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: protein deubiquitination [TASLink to PubMed article]
    ubiquitin-dependent protein catabolic process [TASLink to PubMed article]
    Molecular Function: ubiquitin thiolesterase activity [ISSLink to PubMed article]
    cysteine-type peptidase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSLSESSTS SYHGKRPRSL SEESQSSSNM DDISQKSISL GDASEISKNL PSIAEQKQLI  60
   61 GELVNNQPEL ELGQVDNYIL SYSWYERLCS YLAEDGPFPG PVDQEDIADL ETGTLKPDLQ 120
  121 EEIDFTIISR DVWDLLVRWY GLKGPEFPRE TVNLGSESHP HLVVEVYPPI FSLTLLSTNA 180
  181 VDANESHKPK KISLSSKSTL EDLLEGVKYT LSLPSDQFRL WRVDTDQPLH RTIDPSSFIK 240
  241 INSKEIIDFL EKSKTLVELG MDSSCSLVAE CMINETWPVD RALRLQFLIQ QRNNQSSNEE 300
  301 QKQEKRVPGT CGLSNLGNTC YMNSALQCLT HTRELRDFFT SDEWKNQVNE SNPLGMGGQV 360
  361 ASIFASLIKS LYSPEHSSFA PRQFKATIGK FNHSFLGYGQ QDSQEFLAFL LDGLHEDLNR 420
  421 IYQKPYTSKP DLYEVDEEKI KNTAEECWRL HKLRNDSLIV DLFQGMYRST LVCPVCNTVS 480
  481 ITFDPFMDLT LPLPVKQVWS HTVTFIPADT NLTPLAIEVV LESKAATIED LVKYVAEKSG 540
  541 CSDYRKILVT ETYKGRFYRF LTQLSKSLLM EISEEDEIYL YELERPYEDG SDDILVPVYH 600
  601 ISDDSTNSAN SYMSSRDFGH PFVLQLSDNE VTDASFISEK LKLKYQQFTT LKNLKNIDSL 660
  661 ESLELGHEDE QVQKGPLDVD MDHSQTPLFE MRVFHDRFEK IPTGWNMSVS NLPLLTERDK 720
  721 KDLESTVDPL DAHSIEEEDD SEFKDVAPGS YPEPSKSNEN TKLTAKENDR LLIQGDLLVC 780
  781 EWPEKSYQFV FSVAPSSPQM GRSLWLESKT ILSDKKDDSE DSRTITLNDC LDEFEKTEQL 840
  841 GEEDPWYCPT CKEFRQASKQ MEIWRCPEIL IFHLKRFSSE RRFRDKIDDL VEFPIDNLDM 900
  901 SMRTGSYKLS EKENPKLIYE LYAVDNHYGG LGGGHYTAFA KNPDNGQFYC FDDSRVTPVC 960
  961 PEETVTSAAY LLFYRRKTS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..157] PSI-BLAST 28.39794 Solution structure of the DUSP domain of hUSP15
    2 View Details [158..284] deduced N/A No confident structure predictions are available.
    3 View Details [285..630] PSI-BLAST 61.221849 No description for 2gfoA was found.
    4 View Details [631..979] PSI-BLAST 36.09691 Ubiquitin carboxyl-terminal hydrolase 7 (USP7, HAUSP)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • small conjugating protein-specific protease activity
    		•  6.17519305564032 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  6.1483519675549 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  5.52349554716375 bayes_pls_golite062009
  • binding
    		•  2.43973746940455 bayes_pls_golite062009
  • peptidase activity
    		•  2.16260367986128 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  1.99772512443601 bayes_pls_golite062009
  • protein binding
    		•  1.98124019646987 bayes_pls_golite062009
  • endopeptidase activity
    		•  1.65083162170561 bayes_pls_golite062009
  • cysteine-type endopeptidase activity
    		•  1.33423779714503 bayes_pls_golite062009
  • hydrolase activity
    		•  1.28832055307406 bayes_pls_golite062009
  • catalytic activity
    		•  0.639120026974844 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • cysteine-type peptidase activity
    		•  6.54685807643041 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  6.39247995905454 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  5.91394445088241 bayes_pls_golite062009
  • ubiquitin thiolesterase activity
    		•  4.1832081096766 bayes_pls_golite062009
  • peptidase activity
    		•  3.28868056127375 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  3.01472402774099 bayes_pls_golite062009
  • thiolester hydrolase activity
    		•  2.96735553959103 bayes_pls_golite062009
  • SUMO-specific protease activity
    		•  2.65263825059319 bayes_pls_golite062009
  • hydrolase activity
    		•  2.29464693834116 bayes_pls_golite062009
  • endopeptidase activity
    		•  2.26699762664334 bayes_pls_golite062009
  • cysteine-type endopeptidase activity
    		•  1.95802900199539 bayes_pls_golite062009
  • binding
    		•  1.3276268995308 bayes_pls_golite062009
  • catalytic activity
    		•  1.05972260874031 bayes_pls_golite062009
  • protein binding
    		•  1.01104209091599 bayes_pls_golite062009
  • NEDD8-specific protease activity
    		•  0.687958315289315 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.467924587720185 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.439226369799415 bayes_pls_golite062009
  • calcium-dependent cysteine-type endopeptidase activity
    		•  0.196538841514154 bayes_pls_golite062009
  • DNA binding
    		•  0.168761518285256 bayes_pls_golite062009
  • transferase activity
    		•  0.0852393573521809 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle