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Protein Overview: tpr1

General Information:
Name(s) found: tpr1 / SPAC27D7.14c [Sanger Pombe]
Description(s) found:
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  • pir||T38447 tetratricopeptide repeat protein - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|4056546|emb|CAA22581.1| SPAC27D7.14c [Schizosaccharomyces pombe] [NCBI NR]
  • gi|2664248|emb|CAA15833.1| RNA polymerase II associated Paf1 complex subunit Tpr1 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|26400735|sp|O42668.1|TPR1_SCHPO RecName: Full=Tetratricopeptide repeat protein 1 [NCBI NR]
  • gi|19115532|ref|NP_594620.1| RNA polymerase II associated Paf1 complex subunit Tpr1 [Schizosaccharomyces pombe] [NCBI NR]
  • RNA polymerase II associated Paf1 complex subunit Tpr1 [Sanger Pombe]
  • Tetratricopeptide repeat protein 1 OS=Schizosaccharomyces pombe GN=tpr1 PE=1 SV=1 [Swiss-Prot]
  • TPR1 PROTEIN TETRATRICOPEPTIDE REPEAT PROTEIN: O42668;O42796; [pompepVF.fasta]
  • Tetratricopeptide repeat protein 1 [pompep4896]
  • |tpr1|SPAC637.02c|TPR repeat protein [pompepnew.fasta]
  • |tpr1|SPAC637.02c|TPR repeat protein|Schizosaccharomyces pombe|chr 1|||Manual [pombe041504.fasta]
  • tpr1 protein [Schizosaccharomyces pombe]gi|2664248|emb|CAA15833.1| TPR repeat protein; involved in transcription elongation (regulation) (predicted) (PMID 11884586); RNA polymerase II associated Paf1 complex (PMID 11884586) (predicted); similar to S. cer [nrdb_11152004_Chlamydomonas]
  • (O42668) Tetratricopeptide repeat protein 1 [pompep4896_normal_reversed]
  • |tpr1|SPAC637.02c|RNA polymerase II associated Paf1 complex subunit Tpr1|Schizosaccharomyces pombe|chr 1|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • SPAC27D7.14c [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • hypothetical protein SPAC27D7.14c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • Tetratricopeptide repeat protein 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=tpr1 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 1039 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    spindle pole body [IDALink to PubMed article]
    Cdc73/Paf1 complex [ISSLink to PubMed article]
    Biological Process: potassium ion transport [IMPLink to PubMed article]
    cellular potassium ion homeostasis [TASLink to PubMed article]
    cellular water homeostasis [TASLink to PubMed article]
    RNA elongation from RNA polymerase II promoter [ISSLink to PubMed article]
    Molecular Function: potassium ion binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEGFTLETHA SRIIEVPLLG QEDQSVEIDC SSLPSDATEL CEILVNEQAP REFWTKFAHE  60
   61 YYIRGLREQA ILILKSGLET LKDSESLCIL NANIAAIYLS MAREAMLKKD TDLRDEQLRN 120
  121 VRTYLEAANN IDSKSEINVL LHGIYRILLN PTDKESLENA ARCFDFVLQK SGGNILGFLG 180
  181 KARILYAKGN YRSALKLYQR ALVSNPQFKP DPRIGIGLCF WNLDMKTDAL SAWTRVQQLD 240
  241 PKNTVVDTYI GLYYYDLAFQ NVNNDSFVQN YGKALQHIQR AFKTRNNDPV ASSILERYVY 300
  301 SKKNYEGCIK LAENVIQNSF SSSLIADGYY WMGRAYHQMG NNEKAMASYQ KAKAADDRHL 360
  361 LSSVGIGQIQ ILQNDLTSAK LTFERIAEQN QSCFEALVVL GCLHASDSKP DLTKARMLLD 420
  421 RAFNLVGSSK LPRVVDSDLY ITQARLWEKE DTKKSLGFLT RALDFLESAH MSVGPELLNN 480
  481 IAVLQYHLGL IPEAHGNIIK AKSVLPDANP ELSLLLDYNL ARCEEELGNT SVASEAYVSI 540
  541 LEKHPSFIDA RIRKCLLQLS NPNEETFKEI RHIMNADSQN LEVRAFFGWY LSKQKRRPVE 600
  601 DPEVRHCSQT LRHWHDDIYS LVQLGNAYMR QAREFRVHND REKLKRQKLY IKAIQSYDQA 660
  661 IKFDPKNAHA AQGIAIILAQ NRQFSKALLI LSKVREAIKD ATTLINIGNC LAELKQFSRA 720
  721 IEVFETVYSS TGESDTYGVL SCLGRVWLQR GRESKNVDYL KESVRYATLA LEKNPENPSL 780
  781 LFNVAFVQFQ LCELIRQKPE NSRTVEDLNF AMQQLDASIE TFTKLVSVEH PPYSPTSIEQ 840
  841 RAKMAKNTTK RQLERAIQAQ IEYEKSVAAK LEDARIQREK EKARRLAEEE ALLKEKQERE 900
  901 RQLQEERQKM QEEVLEWRKS QQKASEDDMS LSDDEEKQSG KKKKKDRKKR KSKSKQESSD 960
  961 SGVSEDDEIP LSDARNKTKK RRVNRRVISE EYTFDQDSDA EGNQEEEVSR TIEEKQDNDI1020
 1021 TDNQDDNKEL NLFSEEDEE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..261] PSI-BLAST 44.39794 The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha.
    2 View Details [262..508] PSI-BLAST 7.09691 Crystal structure of the CHIP U-box E3 ubiquitin ligase
    3 View Details [509..942] FFAS03 4.5 No description for 2gw1A was found.
    4 View Details [943..1039] MSA 2.125997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription elongation regulator activity
    		•  5.44222943389468 bayes_pls_golite062009
  • RNA polymerase II transcription elongation factor activity
    		•  3.43202137469601 bayes_pls_golite062009
  • binding
    		•  2.52126334054344 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.36571535004008 bayes_pls_golite062009
  • DNA binding
    		•  1.71381351716702 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.61516860680687 bayes_pls_golite062009
  • protein binding
    		•  1.52807685989528 bayes_pls_golite062009
  • transcription factor activity
    		•  1.01338808398786 bayes_pls_golite062009
  • transcription factor binding
    		•  0.518146612491969 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.30464889749774 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.116119418380222 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0593768116971065 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle