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Protein Overview: thp1

General Information:
Name(s) found: thp1 / SPCC965.05c [Sanger Pombe]
Description(s) found:
Found 23 descriptions.
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  • uracil DNA N-glycosylase Thp1 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 325 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: DNA repair [ICLink to PubMed article]
    mismatch repair [IEA]
    Molecular Function: uracil DNA N-glycosylase activity [IDALink to PubMed article]
    mismatched DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNDIETRDTG TKNDNSSEFN LSVKSHKRKR SFDDENLELE ESREETSGGI LKKAKTQSFS  60
   61 ESLERFRFAH AGSNNEYRKT DVVKNSDTDN GLLKSAVETI TLENGLRNRR VNVTKKSTLK 120
  121 ASVKKSTLKK KNEVDPALLQ GVPDYICENP YAIIVGLNPG ITSSLKGHAF ASPSNRFWKM 180
  181 LNKSKLLEGN AEFTYLNDKD LPAHGLGITN LCARPSSSGA DLRKEEMQDG ARILYEKVKR 240
  241 YRPQVGLFIS GKGIWEEMYK MLTGKKLPKT FVFGWQPEKF GDANVFVGIS SSGRAAGYSD 300
  301 EKKQNLWNLF AEEVNRHREI VKHAV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..128] deduced N/A No confident structure predictions are available.
    2 View Details [129..325] PSI-BLAST 59.0 Crystal Structure of SUMO1-conjugated thymine DNA glycosylase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • DNA N-glycosylase activity
    		•  5.22461096584694 bayes_pls_golite062009
  • hydrolase activity, hydrolyzing N-glycosyl compounds
    		•  4.68115068202636 bayes_pls_golite062009
  • uracil DNA N-glycosylase activity
    		•  4.48822773983461 bayes_pls_golite062009
  • hydrolase activity, acting on glycosyl bonds
    		•  2.66280504021689 bayes_pls_golite062009
  • hydrolase activity
    		•  1.91716804176625 bayes_pls_golite062009
  • catalytic activity
    		•  1.59111295908728 bayes_pls_golite062009
  • binding
    		•  1.2276262882727 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.22310035950527 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.901890891144085 bayes_pls_golite062009
  • DNA binding
    		•  0.850361767185031 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.543168797464517 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.48698673207018 bayes_pls_golite062009
  • protein binding
    		•  0.272261244770552 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle