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View Structure Prediction Details

Protein: thp1
Organism: Schizosaccharomyces pombe
Length: 325 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for thp1.

Description E-value Query
Range
Subject
Range
gi|1378107 - gi|1378107|gb|AAC50540.1| G/T mismatch-specific thymine DNA glycosylase
271.0 [0..55] [323..21]
gi|82957552 - gi|82957552|ref|XP_906828.1| PREDICTED: similar to thymine DNA glycosylase isoform 2 isoform 4 [Mus ...
253.0 [0..64] [324..33]
gi|109098502, gi... - gi|109098504|ref|XP_001096531.1| PREDICTED: thymine-DNA glycosylase isoform 4 [Macaca mulatta], gi|1...
253.0 [0..55] [323..21]

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Predicted Domain #1
Region A:
Residues: [1-128]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNDIETRDTG TKNDNSSEFN LSVKSHKRKR SFDDENLELE ESREETSGGI LKKAKTQSFS  60
   61 ESLERFRFAH AGSNNEYRKT DVVKNSDTDN GLLKSAVETI TLENGLRNRR VNVTKKSTLK 120
  121 ASVKKSTL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [129-325]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKKNEVDPAL LQGVPDYICE NPYAIIVGLN PGITSSLKGH AFASPSNRFW KMLNKSKLLE  60
   61 GNAEFTYLND KDLPAHGLGI TNLCARPSSS GADLRKEEMQ DGARILYEKV KRYRPQVGLF 120
  121 ISGKGIWEEM YKMLTGKKLP KTFVFGWQPE KFGDANVFVG ISSSGRAAGY SDEKKQNLWN 180
  181 LFAEEVNRHR EIVKHAV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 59.0
Match: 1wywA
Description: Crystal Structure of SUMO1-conjugated thymine DNA glycosylase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA N-glycosylase activity 5.22461096584694 bayes_pls_golite062009
hydrolase activity, hydrolyzing N-glycosyl compounds 4.68115068202636 bayes_pls_golite062009
uracil DNA N-glycosylase activity 4.48822773983461 bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds 2.66280504021689 bayes_pls_golite062009
hydrolase activity 1.91716804176625 bayes_pls_golite062009
catalytic activity 1.59111295908728 bayes_pls_golite062009
binding 1.2276262882727 bayes_pls_golite062009
structure-specific DNA binding 1.22310035950527 bayes_pls_golite062009
nucleic acid binding 0.901890891144085 bayes_pls_golite062009
DNA binding 0.850361767185031 bayes_pls_golite062009
transcription regulator activity 0.543168797464517 bayes_pls_golite062009
single-stranded DNA binding 0.48698673207018 bayes_pls_golite062009
protein binding 0.272261244770552 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle