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View Structure Prediction Details

Protein: thp1
Organism: Schizosaccharomyces pombe
Length: 325 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for thp1.

Description E-value Query
Range
Subject
Range
gi|1378107 - gi|1378107|gb|AAC50540.1| G/T mismatch-specific thymine DNA glycosylase
271.0 [0..55] [323..21]
gi|82957552 - gi|82957552|ref|XP_906828.1| PREDICTED: similar to thymine DNA glycosylase isoform 2 isoform 4 [Mus ...
253.0 [0..64] [324..33]
gi|109098502, gi... - gi|109098504|ref|XP_001096531.1| PREDICTED: thymine-DNA glycosylase isoform 4 [Macaca mulatta], gi|1...
253.0 [0..55] [323..21]

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Predicted Domain #1
Region A:
Residues: [1-128]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNDIETRDTG TKNDNSSEFN LSVKSHKRKR SFDDENLELE ESREETSGGI LKKAKTQSFS  60
   61 ESLERFRFAH AGSNNEYRKT DVVKNSDTDN GLLKSAVETI TLENGLRNRR VNVTKKSTLK 120
  121 ASVKKSTL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [129-325]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKKNEVDPAL LQGVPDYICE NPYAIIVGLN PGITSSLKGH AFASPSNRFW KMLNKSKLLE  60
   61 GNAEFTYLND KDLPAHGLGI TNLCARPSSS GADLRKEEMQ DGARILYEKV KRYRPQVGLF 120
  121 ISGKGIWEEM YKMLTGKKLP KTFVFGWQPE KFGDANVFVG ISSSGRAAGY SDEKKQNLWN 180
  181 LFAEEVNRHR EIVKHAV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 59.0
Match: 1wywA
Description: Crystal Structure of SUMO1-conjugated thymine DNA glycosylase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA N-glycosylase activity 5.22461096584694 bayes_pls_golite062009
hydrolase activity, hydrolyzing N-glycosyl compounds 4.68115068202636 bayes_pls_golite062009
uracil DNA N-glycosylase activity 4.48822773983461 bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds 2.66280504021689 bayes_pls_golite062009
hydrolase activity 1.91716804176625 bayes_pls_golite062009
catalytic activity 1.59111295908728 bayes_pls_golite062009
binding 1.2276262882727 bayes_pls_golite062009
structure-specific DNA binding 1.22310035950527 bayes_pls_golite062009
nucleic acid binding 0.901890891144085 bayes_pls_golite062009
DNA binding 0.850361767185031 bayes_pls_golite062009
transcription regulator activity 0.543168797464517 bayes_pls_golite062009
single-stranded DNA binding 0.48698673207018 bayes_pls_golite062009
protein binding 0.272261244770552 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle