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Protein Overview: ste20

General Information:
Name(s) found: ste20 / SPBC12C2.02c [Sanger Pombe]
Description(s) found:
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  • gi|984210|emb|CAA90815.1| Rictor homolog, Ste20 [Schizosaccharomyces pombe] [NCBI NR]
  • pir||T39379 sexual differentiation and meiosis protein ste20 - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|3402266|emb|CAA11758.1| Ste20 protein [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19112813|ref|NP_596021.1| sterility protein Ste20 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|1175418|sp|Q09743.1|STE16_SCHPO RecName: Full=Protein ste16 [NCBI NR]
  • sterility protein Ste20 [Sanger Pombe]
  • Protein ste16 OS=Schizosaccharomyces pombe GN=ste16 PE=2 SV=1 [Swiss-Prot]
  • (Q09743) Protein ste16 [Swiss-Prot]
  • REQUIRED FOR SEXUAL DIFFERENTIATION AND MEIOSIS: Q09743; [pompepVF.fasta]
  • Protein ste16 [pompep4896]
  • |ste16||WD repeat protein [pompepnew.fasta]
  • |ste16||HR1 repeat|Schizosaccharomyces pombe|chr 2|||Manual [pombe041504.fasta]
  • required for sexual differentiation and meiosis [Schizosaccharomyces pombe]gi|3402266|emb|CAA11758.1| Ste20 protein [Schizosaccharomyces pombe]gi|984210|emb|CAA90815.1| SPBC12C2.02c [Schizosaccharomyces pombe]gi|1175418|sp|Q09743|ST16_SCHPO Protein ste [nrdb_11152004_Chlamydomonas]
  • |ste20|ste16|Rictor homolog, Ste20|Schizosaccharomyces pombe|chr 2|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • SPBC12C2.02c [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • hypothetical protein SPBC12C2.02c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • Ste20 protein [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • |ste20|ste16|sterility protein Ste20|Schizosaccharomyces pombe|chr 2|||Manual [spombe-190209-contam.fasta]
  • Protein ste16 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ste16 PE=3 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 1309 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    TORC2 complex [IDALink to PubMed article]
    cell division site [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    integral to membrane [IEA]
    cytosol [IDALink to PubMed article]
    Biological Process: small GTPase mediated signal transduction [ISSLink to PubMed article]
    TOR signaling pathway [TASLink to PubMed article]
    cellular response to nitrogen starvation [IEPLink to PubMed article]
    regulation of conjugation with cellular fusion [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKPVRRGQTD TALDISSHAK TNGDFIKKMN TTDSKRLKLL EDLKGKLEVE CKIRDGAETL  60
   61 LQVFDTNFKK ETKERKEMLK KKCTDELESS KKKIEELVSS IESFQGENGE AKTGSTSLTR 120
  121 SASATVSRKS SLQEKYSTRF SYKAGCSDSC SVTVSGTGEL IGPTRNAHSN LTPTVIQRID 180
  181 FENVNEKNNS SSEDTQPNGK RPSSLQSNFS QFPLNPWLDN IYKACLEGSM KDVIDSSNNL 240
  241 CEYLHEHSDP AYAKNFSLIT PTILSMLELN VSEVTASVYR LLRHLFLDAT AFSCCQMLNL 300
  301 PWILSKSLLS GTDAYQIERE QAFRLIRTLY FLSSTEGHED YLSGITRTII SICEHVSDVS 360
  361 RGIAVETLIE LMIIRPKILF KANGLRVLMI SLIDGSISEN LAASAALALV YLLDDPESAC 420
  421 YVNLPYDIGI LLSPFTSSSS RDTFNSSEEQ SEQAAKAMKS SAKVASVLLN SWSGLLALST 480
  481 NDFQALRSIV DTLRVPSFAP RSDVIDLFFL IFQVEYSSWS ESFLAGKRLT VVKNQAVSND 540
  541 DNINMVNIPD GSNKKYMSLR QHFTAVLLFI FLELGLVESI VCMIRASDDP SASRKATYLL 600
  601 GEVLRLSDEL LPIHLGAKIQ SLPSLFNMAS QFTAEDRFVA TSVLQSIESL NRVKFHSATQ 660
  661 PFSQTTSLLF KEQKTDGSFR GQRQVEHVKL KMGMQIDDSH FRSMLAETNV LATKNYQKWR 720
  721 WDTLVQIMEG PLLSPKRIDE TLRTTKFMRR LLAFYKPFSN RFSSIQNTKP NQKFIKVGCL 780
  781 VFRTLLANPE GVKYLSESKV IKQIAESLSQ IDGYSEQVSE PIFSNSRLQK TLTHGYFPML 840
  841 KVLSSQKEGH AIMERWRIFT TLYHLTELRN RDDLIIIFLT NLDYRLEGHT RIIFSKALNT 900
  901 GQQAVRLTAT KHLAALINSE SANDNLNHWA ISLLIFQLYD PCLEVCKTAV KVLNEVCARN 960
  961 ENLLAQVVQL QPSLAHLGEI GSPLLLRFLA TTVGFHYLSE INFIEHELDN WYHHRNIDYV1020
 1021 DLLEQNFFLS FVSNLKIIDK KNNEPDENIL PLHFYGELVK SPQGCEVLES SGHFESFMGT1080
 1081 LVEFYDKPLG NEAIRQLKSA LWAIGNIGKT DQGITFLINH DTIPLIVKYA ENSLIPTVRG1140
 1141 TAYFVLGLIS RTSKGVEILE SLHWYSLMSL MGTSQGICIP RHAGQVLSTP RRNVEFVNER1200
 1201 VPTPEFSSLL SSLTNSEREV IRLVSNLSNH VLTNESARQL TKIRSKNAKV FSSKRLVKAC1260
 1261 MTILGKFHYR VQIQQFVFEL FPYSVLLSSS TSQDLNESPS RPNNLSISA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..170] PSI-BLAST 13.69897 Structure of a helically extended SH3 domain of the T cell adapter protein ADAP
    2 View Details [171..252] FFAS03 1.02 Crystal structure of the HspBP1 core domain
    3 View Details [253..990] FFAS03 1.08 No description for 2ie3A was found.
    4 View Details [991..1117] MSA 1.04498 View MSA. No confident structure predictions are available.
    5 View Details [1118..1208] deduced N/A No confident structure predictions are available.
    6 View Details [1209..1309] MSA 1.020978 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  3.06905798270146 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.21254869336424 bayes_pls_golite062009
  • protein binding
    		•  2.08632303609243 bayes_pls_golite062009
  • actin binding
    		•  1.79651396322487 bayes_pls_golite062009
  • actin filament binding
    		•  1.03574214978228 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  2.96084803796407 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.39117996950187 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.93307188158984 bayes_pls_golite062009
  • DNA binding
    		•  1.77969838181048 bayes_pls_golite062009
  • protein binding
    		•  1.61131270705552 bayes_pls_golite062009
  • transcription factor activity
    		•  1.02508422532466 bayes_pls_golite062009
  • kinase activity
    		•  0.927598860906311 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.913976209573995 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.824446524918749 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.632985761187158 bayes_pls_golite062009
  • protein kinase activity
    		•  0.632472431834211 bayes_pls_golite062009
  • transferase activity
    		•  0.574559666809629 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.37240198519167 bayes_pls_golite062009
  • actin binding
    		•  0.171976353606808 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.109457212542021 bayes_pls_golite062009
  • protein phosphatase binding
    		•  0.0831993958662147 bayes_pls_golite062009
  • transcription activator activity
    		•  0.061709024440191 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.0342115143082778 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.0272200107208467 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.85

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle