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Protein Overview: sak1

General Information:
Name(s) found: sak1 / SPAC3G9.14 [Sanger Pombe]
Description(s) found:
Found 17 descriptions.
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  • transcriptional repressor Sak1 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 766 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article][ISSLink to PubMed article]
    nuclear chromatin [ICLink to PubMed article]
    cytoplasm [ISSLink to PubMed article]
    Biological Process: positive regulation of exit from mitosis [IMPLink to PubMed article]
    negative regulation of transcription [ICLink to PubMed article]
    regulation of transcription, DNA-dependent [IEA]
    gene-specific transcription from RNA polymerase II promoter [IC]
    regulation of mitotic cell cycle [IGILink to PubMed article]
    Molecular Function: DNA binding [TASLink to PubMed article]
    specific transcriptional repressor activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNPSDLPGQI PLSRSDMNVQ DQLDPVQRFD THFMLPQEEN FLNRPSITSE SAHPRGSDLE  60
   61 QETELKRLAL EHEHYSLESL AEKLRMDHVS ANSEKFRQVF GICWLKRACE EQQDAAVQRN 120
  121 QIYAHYVEIC NSLHIKPLNS ASFGKLVRLL FPSIKTRRLG MRGHSKYHYC GIKLRGQDSF 180
  181 RRLRTFSDSS LSPVSCSSFP KPIPNHFEND VSSIQNTNQR VESSPASVNA AAIVRKSAVT 240
  241 PSSDPYNSPP PSIPLLGSQT NLQLAPSFAA PQAHPLPSHL SQSNVPPQLS HSSVPSPAPP 300
  301 RSVSQPTYFS QPMPQFSSSF VPGTSSIVPT LHPASAQEDF NLQHSLFFKL KLKFLPPHKL 360
  361 PWIPSLDVSS FSLPPIDYYL NGPYDNVEAK SALMNIYSSH CITLIESVRY MHLKQFLSEI 420
  421 SNFPNSLSPS LLALLSSPYF TKWIERSDTV MYREILKLLF PMTLQVVPPP VLVLLRHLAE 480
  481 NLVNHISSIY ASHSSCLLQV KSETAAIFSN LLSRLLRVND TAHAAARFLA NPADRHLICN 540
  541 DWERFVSTRF IVHRELMCND KEAVAALDEW YSILSTCSNP SELLDPLKDK HEASDTSMNR 600
  601 VELRQIDGVL DRMADFFLEL PSRFPSCSPR MFLLCLGALQ TSVLREITVS GGEAFGALWV 660
  661 IRCWVDEYMT WVAEIGGYLD DSYDELEQHH ANFHNKAGIS QSNIPPHLQE HRQSQQHFQQ 720
  721 DIEALQSQQQ QQATKNSLME AAYQNAQKQK EDDYISIVFD TNGACS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..84] deduced N/A No confident structure predictions are available.
    2 View Details [85..176] PSI-BLAST 26.221849 Class II MHC transcription factor RFX1
    3 View Details [177..383] MSA 12.226997 View MSA. No confident structure predictions are available.
    4 View Details [384..627] deduced N/A No confident structure predictions are available.
    5 View Details [628..766] MSA 2.053975 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  5.55329976718261 bayes_pls_golite062009
  • DNA binding
    		•  4.84466441605416 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.57954522145536 bayes_pls_golite062009
  • transcription factor activity
    		•  4.12685284895733 bayes_pls_golite062009
  • binding
    		•  3.52874320222492 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.60738445921725 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.3918869755162 bayes_pls_golite062009
  • transcription activator activity
    		•  2.37668609508629 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.22485867684613 bayes_pls_golite062009
  • protein binding
    		•  1.80415286835431 bayes_pls_golite062009
  • transcription factor binding
    		•  0.85714789329232 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.66743181561551 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.181186586600235 bayes_pls_golite062009
  • structural molecule activity
    		•  0.111941063082739 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.0360186926687502 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle