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Protein Overview: pms1

General Information:
Name(s) found: pms1 / SPAC19G12.02c [Sanger Pombe]
Description(s) found:
Found 21 descriptions.
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  • MutL family mismatch-repair protein Pms1 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 794 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    nuclear chromosome [ISSLink to PubMed article]
    Biological Process: maintenance of DNA repeat elements [IMPLink to PubMed article]
    mismatch repair [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: ATPase activity [ISSLink to PubMed article]
    ATP binding [ISSLink to PubMed article]
    DNA binding [ISSLink to PubMed article]
    mismatched DNA binding [NASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTVKPIDAN TVHKICSGQV ITDVASAVKE LVENSLDSGA TTIEIRFKNY GINSIEVVDN  60
   61 GSGIDAGDYE SIGKKHFTSK ITDFEDLEAL QTFGFRGEAL SSLCAVGQVI ISTATQNEAP 120
  121 KGVQLNLDHE GSLKDKLTIP FQRGTSVMVN DLFCTLPVRR KLLEKNYKRE FSKAISLLQA 180
  181 YATISTNKRF MVYHQTKNSG KLLQLSTNSN KDMKLNIMNV FGTKVSSSLI PWNDGIIEGY 240
  241 ISRPHVGSTR ASNERQMLFI NRRLVNLPKI ARVIQEVFKP YSMAQSPFFA INLRITNGTI 300
  301 DINVSPDKKS VFLSEEDSII EFIKNSLQNL CESCGHAISC SRSQSIFSYS SQIPDSSGDS 360
  361 TDQELPQSIP ATESETSDDS SFSYKRSPCK RKLVEATAQP AISTSVAEGA SLAQVSKPLP 420
  421 ERLQKDSMRR SSPLNEKVTA SSERMKKKLA LFASSTDTSM QKTIDSSFPL KQPINKPSSN 480
  481 PNNLLLNDPS PASTPVAKTI NLNEIESVHN AESVSTLSSI PRTEQTSVAN RIPSKTAALQ 540
  541 KLKFFQSRPL DGLNKFSKKI NISLSGVQKD IVRSDALLKF SNKIGVVHDI SDENQEDHLN 600
  601 LTVHKADFLR MRVVGQFNRG FIVVVHGNNL FIIDQHASDE KFNYEHLKSN LVINSQDLVL 660
  661 PKRLDLAATE ETVLIDHIDL IRRKGFGVAI DLNQRVGNRC TLLSVPTSKN VIFDTSDLLE 720
  721 IISVLSEHPQ IDPFSSRLER MLASKACRSS VMIGRALTIS EMNTIVRHLA ELSKPWNCPH 780
  781 GRPTMRHLLR LKDI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..194] PSI-BLAST 61.522879 DNA mismatch repair protein PMS2
    2 View Details [195..608] PSI-BLAST 26.221849 No description for 2cgeA was found.
    3 View Details [609..794] PSI-BLAST 22.30103 Crystal structure of the MutL C-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • mismatched DNA binding
    		•  3.57655116178667 bayes_pls_golite062009
  • DNA insertion or deletion binding
    		•  2.46227149317121 bayes_pls_golite062009
  • protein kinase activity
    		•  2.13536672517084 bayes_pls_golite062009
  • catalytic activity
    		•  2.10890475146569 bayes_pls_golite062009
  • mismatch repair complex binding
    		•  1.96854808883516 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.77725015786603 bayes_pls_golite062009
  • kinase activity
    		•  1.56098992648511 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.53059432571568 bayes_pls_golite062009
  • DNA topoisomerase (ATP-hydrolyzing) activity
    		•  1.52200964813377 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.37978051130887 bayes_pls_golite062009
  • DNA topoisomerase activity
    		•  1.36273548338019 bayes_pls_golite062009
  • binding
    		•  1.35389889022794 bayes_pls_golite062009
  • DNA binding
    		•  1.31521246060081 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.22640171545155 bayes_pls_golite062009
    		• 1.22535455712591 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.22084067619837 bayes_pls_golite062009
  • guanine/thymine mispair binding
    		•  1.13287005339637 bayes_pls_golite062009
  • transferase activity
    		•  1.09369139087478 bayes_pls_golite062009
  • signal transducer activity
    		•  0.996368427522977 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.996368427522977 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.91402301750067 bayes_pls_golite062009
  • MutSalpha complex binding
    		•  0.8423412194292 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.839521076707668 bayes_pls_golite062009
  • single base insertion or deletion binding
    		•  0.838219201635811 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.548987072359833 bayes_pls_golite062009
  • dinucleotide insertion or deletion binding
    		•  0.527926050401 bayes_pls_golite062009
  • loop DNA binding
    		•  0.357652405116621 bayes_pls_golite062009
  • protein binding
    		•  0.0159124601670583 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle