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View Structure Prediction Details

Protein: pms1
Organism: Schizosaccharomyces pombe
Length: 794 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pms1.

Description E-value Query
Range		 Subject
Range
gi|74226946 - gi|74226946|dbj|BAE27115.1| unnamed protein product [Mus musculus]
 480.0 [0..3] [794..14]
gi|169642755, gi... - gi|169642755|gb|AAI60858.1| Pms2 protein [Rattus norvegicus], gi|109496490|ref|XP_001063043.1| PREDI...
 473.0 [0..3] [794..14]
gi|21619309 - gi|21619309|gb|AAH31832.1| PMS2 protein [Homo sapiens]
 466.0 [0..3] [794..31]
gi|114612035 - gi|114612035|ref|XP_001141671.1| PREDICTED: PMS2 postmeiotic segregation increased 2 isoform 2 [Pan ...
 463.0 [0..3] [794..14]
gi|73958129 - gi|73958129|ref|XP_536879.2| PREDICTED: similar to PMS1 protein homolog 2 (DNA mismatch repair prote...
 445.0 [0..3] [794..24]

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Predicted Domain #1
Region A:
Residues: [1-194] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTVKPIDAN TVHKICSGQV ITDVASAVKE LVENSLDSGA TTIEIRFKNY GINSIEVVDN  60
   61 GSGIDAGDYE SIGKKHFTSK ITDFEDLEAL QTFGFRGEAL SSLCAVGQVI ISTATQNEAP 120
  121 KGVQLNLDHE GSLKDKLTIP FQRGTSVMVN DLFCTLPVRR KLLEKNYKRE FSKAISLLQA 180
  181 YATISTNKRF MVYH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 61.522879
Match: 1h7sA
Description: DNA mismatch repair protein PMS2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
mismatched DNA binding 3.57655116178667 bayes_pls_golite062009
DNA insertion or deletion binding 2.46227149317121 bayes_pls_golite062009
protein kinase activity 2.13536672517084 bayes_pls_golite062009
catalytic activity 2.10890475146569 bayes_pls_golite062009
mismatch repair complex binding 1.96854808883516 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.77725015786603 bayes_pls_golite062009
kinase activity 1.56098992648511 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.53059432571568 bayes_pls_golite062009
DNA topoisomerase (ATP-hydrolyzing) activity 1.52200964813377 bayes_pls_golite062009
transcription regulator activity 1.37978051130887 bayes_pls_golite062009
DNA topoisomerase activity 1.36273548338019 bayes_pls_golite062009
binding 1.35389889022794 bayes_pls_golite062009
DNA binding 1.31521246060081 bayes_pls_golite062009
structure-specific DNA binding 1.22640171545155 bayes_pls_golite062009
1.22535455712591 bayes_pls_golite062009
nucleic acid binding 1.22084067619837 bayes_pls_golite062009
guanine/thymine mispair binding 1.13287005339637 bayes_pls_golite062009
transferase activity 1.09369139087478 bayes_pls_golite062009
signal transducer activity 0.996368427522977 bayes_pls_golite062009
molecular transducer activity 0.996368427522977 bayes_pls_golite062009
double-stranded DNA binding 0.91402301750067 bayes_pls_golite062009
MutSalpha complex binding 0.8423412194292 bayes_pls_golite062009
single-stranded DNA binding 0.839521076707668 bayes_pls_golite062009
single base insertion or deletion binding 0.838219201635811 bayes_pls_golite062009
DNA-dependent ATPase activity 0.548987072359833 bayes_pls_golite062009
dinucleotide insertion or deletion binding 0.527926050401 bayes_pls_golite062009
loop DNA binding 0.357652405116621 bayes_pls_golite062009
protein binding 0.0159124601670583 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [195-608] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QTKNSGKLLQ LSTNSNKDMK LNIMNVFGTK VSSSLIPWND GIIEGYISRP HVGSTRASNE  60
   61 RQMLFINRRL VNLPKIARVI QEVFKPYSMA QSPFFAINLR ITNGTIDINV SPDKKSVFLS 120
  121 EEDSIIEFIK NSLQNLCESC GHAISCSRSQ SIFSYSSQIP DSSGDSTDQE LPQSIPATES 180
  181 ETSDDSSFSY KRSPCKRKLV EATAQPAIST SVAEGASLAQ VSKPLPERLQ KDSMRRSSPL 240
  241 NEKVTASSER MKKKLALFAS STDTSMQKTI DSSFPLKQPI NKPSSNPNNL LLNDPSPAST 300
  301 PVAKTINLNE IESVHNAESV STLSSIPRTE QTSVANRIPS KTAALQKLKF FQSRPLDGLN 360
  361 KFSKKINISL SGVQKDIVRS DALLKFSNKI GVVHDISDEN QEDHLNLTVH KADF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.221849
Match: 2cgeA
Description: No description for 2cgeA was found.

Predicted Domain #3
Region A:
Residues: [609-794] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LRMRVVGQFN RGFIVVVHGN NLFIIDQHAS DEKFNYEHLK SNLVINSQDL VLPKRLDLAA  60
   61 TEETVLIDHI DLIRRKGFGV AIDLNQRVGN RCTLLSVPTS KNVIFDTSDL LEIISVLSEH 120
  121 PQIDPFSSRL ERMLASKACR SSVMIGRALT ISEMNTIVRH LAELSKPWNC PHGRPTMRHL 180
  181 LRLKDI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.30103
Match: 1x9zA
Description: Crystal structure of the MutL C-terminal domain
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle