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Protein Overview: pka1

General Information:
Name(s) found: pka1 / SPBC106.10 [Sanger Pombe]
Description(s) found:
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  • gi|729868|sp|P40376.1|KAPB_SCHPO RecName: Full=cAMP-dependent protein kinase catalytic subunit [NCBI NR]
  • pir||A54400 protein kinase (EC 2.7.1.37), cAMP-dependent, catalytic chain - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|5817276|emb|CAB53726.1| cAMP-dependent protein kinase catalytic subunit Pka1 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|484305|dbj|BAA04891.1| catalytic subunit of the cAMP-dependent protein kinase [Schizosaccharomyces pombe] [NCBI NR]
  • gi|473894|gb|AAA70165.1| cAMP-dependent protein kinase [NCBI NR]
  • gi|19111951|ref|NP_595159.1| cAMP-dependent protein kinase catalytic subunit Pka1 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|1093611|prf||2104277A cAMP-dependent protein kinase [NCBI NR]
  • cAMP-dependent protein kinase catalytic subunit Pka1 [Sanger Pombe]
  • cAMP-dependent protein kinase catalytic subunit OS=Schizosaccharomyces pombe GN=pka1 PE=1 SV=1 [Swiss-Prot]
  • CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT: P40376; [pompepVF.fasta]
  • cAMP-dependent protein kinase catalytic subunit (EC 2.7.1.37) [pompep4896]
  • |pka1|tpk, git6|cAMP-dependent protein kinase catalytic subunit (PMID 8144551) [pompepnew.fasta]
  • |pka1|tpk, git6|cAMP-dependent protein kinase (catalytic subunit) (PMID 8144551)|Schizosaccharomyces pombe|chr 2|||Manual [pombe041504.fasta]
  • |pka1|tpk, git6|cAMP-dependent protein kinase |Schizosaccharomyces pombe|chr 2|||Manual [pompep2242005.fasta]
  • cAMP-dependent protein kinase (catalytic subunit) (PMID 8144551); serine/threonine protein kinase; involved in cAMP-mediated signaling; involved in response to nutrients; involved in negative regulation of transcription by glucose; involved in conjugation [nrdb_11152004_Chlamydomonas]
  • (P40376) cAMP-dependent protein kinase catalytic subunit (EC 2.7.1.37) [pompep4896_normal_reversed]
  • |pka1|tpk, git6|cAMP-dependent protein kinase catalytic subunit Pka1|Schizosaccharomyces pombe|chr 2|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • cAMP-dependent protein kinase catalytic subunit [nr-271106-contam.fasta]
  • cAMP-dependent protein kinase [nr-271106-contam.fasta]
  • cAMP-dependent protein kinase [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • SPBC106.10 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • catalytic subunit of the cAMP-dependent protein kinase [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • cAMP-dependent protein kinase catalytic subunit OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=pka1 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 512 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    cAMP-dependent protein kinase complex [TASLink to PubMed article]
    Biological Process: induction of conjugation upon nitrogen starvation [IMPLink to PubMed article]
    negative regulation of transcription by glucose [IMPLink to PubMed article]
    age-dependent response to reactive oxygen species [IGILink to PubMed article][IMPLink to PubMed article]
    protein amino acid phosphorylation [ICLink to PubMed article]
    negative regulation of conjugation with cellular fusion [IMPLink to PubMed article]
    cAMP-mediated signaling [ICLink to PubMed article]
    chronological cell aging [IGILink to PubMed article]
    cellular response to nitrogen starvation [IMPLink to PubMed article]
    Molecular Function: ATP binding [ISSLink to PubMed article]
    protein binding [IPILink to PubMed articleLink to PubMed article]
    cAMP-dependent protein kinase activity [IGILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDTTAVASKG STNVGSSTDT LSTSASLHPS MNAGSVNEYS EQQRHGTNSF NGKPSVHDSV  60
   61 GSDASVSNGH NNHNESSLWT SGIPKALEEA TKSKKPDSLV STSTSGCASA HSVGYQNIDN 120
  121 LIPSPLPESA SRSSSQSSHQ RHSRDGRGEL GSEHGERRSA MDGLRDRHIR KVRVSQLLDL 180
  181 QRRRIRPADH TTKDRYGIQD FNFLQTLGTG SFGRVHLVQS NHNRLYYAIK VLEKKKIVDM 240
  241 KQIEHTCDER YILSRVQHPF ITILWGTFQD AKNLFMVMDF AEGGELFSLL RKCHRFPEKV 300
  301 AKFYAAEVIL ALDYLHHNQI VYRDLKPENL LLDRFGHLKI VDFGFAKRVS TSNCCTLCGT 360
  361 PDYLAPEIIS LKPYNKAADW WSLGILIFEM LAGYPPFYSE NPMKLYENIL EGKVNYPSYF 420
  421 SPASIDLLSH LLQRDITCRY GNLKDGSMDI IMHPWFRDIS WDKILTRKIE VPYVPPIQAG 480
  481 MGDSSQFDAY ADVATDYGTS EDPEFTSIFK DF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..84] PSI-BLAST 3.221849 Polygalacturonase inhibiting protein PGIP
    2 View Details [85..440] PSI-BLAST 53.30103 Hemapoetic cell kinase Hck; Hemopoetic cell kinase Hck; Haemopoetic cell kinase Hck
    3 View Details [441..512] PSI-BLAST 95.69897 cAMP-dependent PK, catalytic subunit


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle