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Protein Overview: Pvf1-PA

General Information:
Name(s) found: Pvf1-PA / FBpp0074411 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • The gene PDGF- and VEGF-related factor 1 is referred to in FlyBase by the symbol Dmel\Pvf1 (CG7103, FBgn0030964). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:18726736..18736934. It has the cytological map location 17E1. There is experimental evidence that it has the molecular function</span>: heparin binding; receptor binding. There is experimental evidence that it is involved in the biological process</span>: border follicle cell migration; cell projection assembly; hemocyte migration; salivary gland morphogenesis. 21 alleles are reported. The phenotypes of these alleles are annotated with: ejaculatory bulb; male terminalia; intersegmental nerve; border follicle cell; embryonic dorsal epidermis. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 325 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDA]
    membrane [IEA]
    extracellular region [ISS]
    Biological Process: hemocyte migration [IEP][IGI][TAS]
    vascular endothelial growth factor receptor signaling pathway [ISS]
    cell projection assembly [IMP]
    border follicle cell migration [IGI][IMP][TAS]
    salivary gland morphogenesis [IMP]
    Molecular Function: growth factor activity [IEA]
    vascular endothelial growth factor receptor binding [ISS][NAS]
    heparin binding [IDA]
    receptor binding [IPI][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAMSRIRILK PMQHPLLILP VLLLVLIVSE AAAGSLVSPN NRQPSQRFFY AAATSSSSTQ  60
   61 TKVRLLRQAD DPSAAPGALE GSCCQGAAAE AGTPLTLPLS VSAELTNVTA DYDVSGEMPS 120
  121 SKENFKRSIM KSTVRNATPA SCSPQPTIVE LKPPAEDEAN YYYMPACTRI SRCNGCCGST 180
  181 LISCQPTEVE QVQLRVRKVD RAATSGRRPF TIITVEQHTQ CRCDCRTKAE DCNVYQSYRK 240
  241 DLCRCECHNT DARDKCLEQA ENKYWVDDNC TCVCRYNQSC TTGTVFDETQ CKCTDPAAPI 300
  301 DVLDRKRFIV QAVQVDPDNT TLYSV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..71] deduced N/A No confident structure predictions are available.
    2 View Details [72..230] PSI-BLAST 24.69897 Placenta growth factor-1, PLGF-1
    3 View Details [231..325] PSI-BLAST 3.69897 Hybrid domain of integrin beta; Integrin beta A domain; Integrin beta tail domain; Integrin beta EGF-like domains

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • vascular endothelial growth factor receptor binding
    		•  5.53296544131638 bayes_pls_golite062009
  • receptor binding
    		•  4.98600168355158 bayes_pls_golite062009
  • vascular endothelial growth factor receptor 2 binding
    		•  4.84894440498579 bayes_pls_golite062009
  • growth factor activity
    		•  4.40342630446728 bayes_pls_golite062009
  • vascular endothelial growth factor receptor 1 binding
    		•  3.72494469310902 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
    		•  3.60727548920187 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase binding
    		•  3.46872954776606 bayes_pls_golite062009
  • transforming growth factor beta receptor binding
    		•  3.46872954776606 bayes_pls_golite062009
  • cytokine activity
    		•  2.94824371215551 bayes_pls_golite062009
  • binding
    		•  2.64101807129423 bayes_pls_golite062009
  • vascular endothelial growth factor receptor 3 binding
    		•  2.49662692173028 bayes_pls_golite062009
  • growth factor binding
    		•  2.41942870726502 bayes_pls_golite062009
  • protein binding
    		•  2.36794464190805 bayes_pls_golite062009
  • cell surface binding
    		•  2.18650685174299 bayes_pls_golite062009
  • platelet-derived growth factor receptor binding
    		•  1.78479767888975 bayes_pls_golite062009
  • type II transforming growth factor beta receptor binding
    		•  1.68851021785811 bayes_pls_golite062009
  • pattern binding
    		•  1.42097884493181 bayes_pls_golite062009
  • heparin binding
    		•  1.29079171602988 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  1.20536536478688 bayes_pls_golite062009
  • platelet-derived growth factor binding
    		•  1.16893591942376 bayes_pls_golite062009
  • hormone activity
    		•  0.94314407550729 bayes_pls_golite062009
  • fibronectin binding
    		•  0.81652439411811 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.697058311884552 bayes_pls_golite062009
  • polysaccharide binding
    		•  0.539968806788969 bayes_pls_golite062009
  • protein homodimerization activity
    		•  0.415660572795793 bayes_pls_golite062009
  • carbohydrate binding
    		•  0.40503978964895 bayes_pls_golite062009
  • neurotrophin receptor binding
    		•  0.35766568682861 bayes_pls_golite062009
  • identical protein binding
    		•  0.273591586673912 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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