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View Structure Prediction Details

Protein: Pvf1-PA
Organism: Drosophila melanogaster
Length: 325 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Pvf1-PA.

Description E-value Query
Range
Subject
Range
Pvf1-PB - The gene PDGF- and VEGF-related factor 1 is referred to in FlyBase by the symbol Dmel\Pvf1 (CG7103, ...
263.0 [0..29] [325..18]

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Predicted Domain #1
Region A:
Residues: [1-71]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAMSRIRILK PMQHPLLILP VLLLVLIVSE AAAGSLVSPN NRQPSQRFFY AAATSSSSTQ  60
   61 TKVRLLRQAD D

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [72-230]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSAAPGALEG SCCQGAAAEA GTPLTLPLSV SAELTNVTAD YDVSGEMPSS KENFKRSIMK  60
   61 STVRNATPAS CSPQPTIVEL KPPAEDEANY YYMPACTRIS RCNGCCGSTL ISCQPTEVEQ 120
  121 VQLRVRKVDR AATSGRRPFT IITVEQHTQC RCDCRTKAE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.69897
Match: 1fzvA
Description: Placenta growth factor-1, PLGF-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
vascular endothelial growth factor receptor binding 5.53296544131638 bayes_pls_golite062009
receptor binding 4.98600168355158 bayes_pls_golite062009
vascular endothelial growth factor receptor 2 binding 4.84894440498579 bayes_pls_golite062009
growth factor activity 4.40342630446728 bayes_pls_golite062009
vascular endothelial growth factor receptor 1 binding 3.72494469310902 bayes_pls_golite062009
receptor serine/threonine kinase binding 3.60727548920187 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase binding 3.46872954776606 bayes_pls_golite062009
transforming growth factor beta receptor binding 3.46872954776606 bayes_pls_golite062009
cytokine activity 2.94824371215551 bayes_pls_golite062009
binding 2.64101807129423 bayes_pls_golite062009
vascular endothelial growth factor receptor 3 binding 2.49662692173028 bayes_pls_golite062009
growth factor binding 2.41942870726502 bayes_pls_golite062009
protein binding 2.36794464190805 bayes_pls_golite062009
cell surface binding 2.18650685174299 bayes_pls_golite062009
platelet-derived growth factor receptor binding 1.78479767888975 bayes_pls_golite062009
type II transforming growth factor beta receptor binding 1.68851021785811 bayes_pls_golite062009
pattern binding 1.42097884493181 bayes_pls_golite062009
heparin binding 1.29079171602988 bayes_pls_golite062009
glycosaminoglycan binding 1.20536536478688 bayes_pls_golite062009
platelet-derived growth factor binding 1.16893591942376 bayes_pls_golite062009
hormone activity 0.94314407550729 bayes_pls_golite062009
fibronectin binding 0.81652439411811 bayes_pls_golite062009
protein dimerization activity 0.697058311884552 bayes_pls_golite062009
polysaccharide binding 0.539968806788969 bayes_pls_golite062009
protein homodimerization activity 0.415660572795793 bayes_pls_golite062009
carbohydrate binding 0.40503978964895 bayes_pls_golite062009
neurotrophin receptor binding 0.35766568682861 bayes_pls_golite062009
identical protein binding 0.273591586673912 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [231-325]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DCNVYQSYRK DLCRCECHNT DARDKCLEQA ENKYWVDDNC TCVCRYNQSC TTGTVFDETQ  60
   61 CKCTDPAAPI DVLDRKRFIV QAVQVDPDNT TLYSV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.69897
Match: 1jv2B
Description: Hybrid domain of integrin beta; Integrin beta A domain; Integrin beta tail domain; Integrin beta EGF-like domains
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle