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Protein Overview: Aats-his-PB

General Information:
Name(s) found: Aats-his-PB / FBpp0074366 [FlyBase]
Description(s) found:
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  • gi|24643059|ref|NP_573305.1| Histidyl-tRNA synthetase, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|22832509|gb|AAN09471.1| Histidyl-tRNA synthetase, isoform B [Drosophila melanogaster] [NCBI NR]
  • The gene Histidyl-tRNA synthetase is referred to in FlyBase by the symbol Dmel\Aats-his (CG6335, FBgn0027087). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:18409432..18414480. It has the cytological map location 17C1. Based on sequence similarity, it is predicted to have molecular function</span>: histidine-tRNA ligase activity. It is reported to be involved in the biological process</span>: histidyl-tRNA aminoacylation. 11 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • >CG6335-PB translation from_gene[CG6335 CG6335 FBgn0030934] seq_release:3 mol_weight=62275 cds_boundaries:(X:18,246,549..18,251,154[+]) aa_length:563 transcript_info:[CG6335-RB seq_release:3] gene_info:[gene symbol:CG6335 FBgn0030934 gene_boundaries:(X [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q8IQX8) CG6335-PB [DrosMelano7227.FASTAC.txt]
  • CG6335-PB, isoform B [Drosophila melanogaster]gi|24643059|ref|NP_573305.1| CG6335-PB [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=X:join(18409623..18409715,18411778..18412116,18412858..18413286,18413348..18413968,18414022..18414231); ID=FBpp0074366; name=Aats-his-PB; parent=FBgn0027087,FBtr0074594; dbxref=FlyBase:FBpp0074366,FlyBase_Annotation_IDs:CG6335-PB,GB_prot [fly-100309-contam.fasta]
  • CG6335-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Histidyl-tRNA synthetase CG6335-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=X:join(18409623..18409715,18411778..18412116,18412858..18413286,18413348..18413968,18414022..18414231); ID=FBpp0074366; name=Aats-his-PB; parent=FBgn0027087,FBtr0074594; dbxref=FlyBase:FBpp0074366,FlyBase_Annotation_IDs:CG6335-PB,GB_protein:AAN09471.1,REFSEQ:NP_573305,GB_protein:AAN09471; MD5=637360bbffa94639f0ff9d427d6bd843; length=563; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=X:join(18409623..18409715,18411778..18412116,18412858..18413286,18413348..18413968,18414022..18414231); ID=FBpp0074366; name=Aats-his-PB; parent=FBgn0027087,FBtr0074594; dbxref=FlyBase:FBpp0074366,FlyBase_Annotation_IDs:CG6335-PB,GB_protein:AAN09471.1,REFSEQ:NP_573305,GB_protein:AAN09471; MD5=637360bbffa94639f0ff9d427d6bd843; length=563; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Histidyl-tRNA synthetase, isoform B OS=Drosophila melanogaster GN=Aats-his PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
    • Organism: Drosophila melanogaster
    Length: 563 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEA]
    Biological Process: histidyl-tRNA aminoacylation [IEA][NAS]
    Molecular Function: histidine-tRNA ligase activity [ISS][NAS]
    ATP binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDTREQILE QIKVQGDLVR QLKAAKESKE KHLSNPHHVH VPSLKSFPAS PLQIDEEVAR  60
   61 LLALKATLGG DAAPTNQKFT LKTPKGTRDY GPQQMTLRQG VLDKIVQVFK RHGGEAIDTP 120
  121 VFELKVSSPG SHWSGMILFK TMRIEVLTGK YGEDSKLIYD LKDQGGEILS MRYDLTVPLA 180
  181 RYLAMNKISS IKRYHIAKVY RRDNPAMTKG RYREFYQCDF DIAGTYDPML PDAECVKIVS 240
  241 EILDTLDIGD YVIKLNHRQL LDGMFQACGV PADSFRTICS AVDKLDKSPW ADVRKEMVDE 300
  301 KGLDEAAADR IGEYVRLSGG AELVEQLLAN EKLKAVPNAV KGLEGMKQLL KYCSIFGLDK 360
  361 RVSFDLSLAR GLDYYTGVIY EGVLKGESAT VASPAKTSQQ NGEQANEPAT VGSVAGGGRY 420
  421 DNLVGMFDPR GKAVPCVGVS IGVERIFSVL EARAAASGLK LRTSDVEVYV ASAHKGLHEQ 480
  481 RLKVLNLLWD AGVKAEHSYK LNPKLLVQLQ HCEEHQIPLV VVLGDAELAQ GLVKLREVTT 540
  541 REETNVKLED LAAEIRRRQQ ASA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..563] PSI-BLAST 92.0 Threonyl-tRNA synthetase (ThrRS), C-terminal domain; Threonyl-tRNA synthetase (ThrRS), N-terminal 'additional' domain; Threonyl-tRNA synthetase (ThrRS), second 'additional' domain; Threonyl-tRNA synthetase (ThrRS)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  7.89468709683036 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  7.89468709683036 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  7.88410036819636 bayes_pls_golite062009
  • ligase activity
    		•  6.92073480193262 bayes_pls_golite062009
  • histidine-tRNA ligase activity
    		•  5.91343220471745 bayes_pls_golite062009
  • phenylalanine-tRNA ligase activity
    		•  2.99105702052936 bayes_pls_golite062009
  • serine-tRNA ligase activity
    		•  2.46505535069103 bayes_pls_golite062009
  • glycine-tRNA ligase activity
    		•  2.29229136935761 bayes_pls_golite062009
  • threonine-tRNA ligase activity
    		•  2.18642354927 bayes_pls_golite062009
  • catalytic activity
    		•  1.99372273395202 bayes_pls_golite062009
  • alanine-tRNA ligase activity
    		•  1.82594054955281 bayes_pls_golite062009
  • lysine-tRNA ligase activity
    		•  1.72324031407565 bayes_pls_golite062009
  • asparagine-tRNA ligase activity
    		•  0.921492123574877 bayes_pls_golite062009
  • binding
    		•  0.916222310895772 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.375542987753806 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.281662799812287 bayes_pls_golite062009
  • DNA binding
    		•  0.0309732052586011 bayes_pls_golite062009
  • aspartate-tRNA ligase activity
    		•  0.00572514744734753 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle