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Protein Overview: FBpp0309136, mth...

General Information:
Name(s) found: FBpp0309136 [FlyBase]
mthl1-PA / FBpp0074089 [FlyBase]
Description(s) found:
Found 29 descriptions.
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  • type=protein; loc=X:16535510..16537540; ID=FBpp0309136; name=mthl1-PB; parent=FBgn0030766,FBtr0340150; dbxref=FlyBase:FBpp0309136,FlyBase_Annotation_IDs:CG4521-PB; MD5=4fb1c04392c84ee0f1421d35ed523356; length=676; release=r5.56; species=Dmel; [FlyBase]
  • The gene methuselah-like 1 is referred to in FlyBase by the symbol Dmel\mthl1 (CG4521, FBgn0030766). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:16534938..16543730. It has the cytological map location 14F4-14F5. Based on sequence similarity, it is predicted to have molecular function</span>: G-protein coupled receptor activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: G-protein coupled receptor protein signaling pathway; determination of adult lifespan; response to stress. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 676 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEA]
    integral to membrane [ISS][NAS]
    Biological Process: G-protein coupled receptor protein signaling pathway [ISS]
    determination of adult lifespan [ISS]
    cell surface receptor linked signaling pathway [IEA]
    response to stress [ISS]
    Molecular Function: G-protein coupled receptor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDRSRSSRAA SSNQFIRPCG LLTTVILLQT LVSMSLAIEE MSPPPAAPPR PSPPPTVKLN  60
   61 KCCHSGEYLN DGTCIAGSEA LWLPMVYLVQ QQRFFEPHGA SPRFLKFLPN TRPTCRKDQT 120
  121 TEIFRSRGAN VMLFPNGTLY VRERALMVQP SDYCVDWEVA VVCLNDSQPI NALEDPDYAA 180
  181 NPLVQQEPPK ASLRLSKCCG KWGSYNTQLQ NCDLQPNHQA AVDGLLRLSP QLPEGSYQTS 240
  241 YGLPDCGQPG GYSIAGDWQD AKLDRNTAML QLPHKNLSAG QYCLEHTQRE GEVKIIACQH 300
  301 LFSSAAGAGI HDGSIGGTIE QANGQNLQKA VLTGGILVSI VFLSATLVAG FLLPAVHHAL 360
  361 HWRCQICYVT CLLFGKILLA IEELSSSLQP GSAACHTLAI TMQFFFLAAF FWLNTMCFNI 420
  421 WWTFRDFRPS SLERNQEALR RYLYSLYAWG GPLLITFVAA CVDQLPETTL LRPGFGQLYC 480
  481 WFDNRNLSIF AYFYGPIGLL LCANIALFVS TTHQLTCGLW KRDDVKSSSE KSALGRVCLK 540
  541 LVVVMGVTWI ADILSWLVGG PHGVWFFTDL INALQGVFIF IVVGCQPQVW TACRRIFCPR 600
  601 LRHDITNTTN GVQHSSSSQG LPSMAGGTEI TQNTTTTTTT TNTTATHMPS NPAEDEVPEK 660
  661 APIAPVAPIV KMETIC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..100] deduced N/A No confident structure predictions are available.
    2 View Details [101..303] PSI-BLAST 29.0 No description for 2pzxA was found.
    3 View Details [304..676] PSI-BLAST 39.045757 Rhodopsin

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • G-protein coupled receptor activity
    		•  7.48253527316663 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  5.76968261800439 bayes_pls_golite062009
  • receptor activity
    		•  5.47976284348283 bayes_pls_golite062009
  • signal transducer activity
    		•  4.51388461085202 bayes_pls_golite062009
  • molecular transducer activity
    		•  4.51388461085202 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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