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Protein Overview: Fur2-PA, Fur2-PB...

General Information:
Name(s) found: Fur2-PB / FBpp0074042 [FlyBase]
Fur2-PC / FBpp0074040 [FlyBase]
Fur2-PA / FBpp0074038 [FlyBase]
Description(s) found:
Found 42 descriptions.
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  • The gene Furin 2 is referred to in FlyBase by the symbol Dmel\Fur2 (CG18734, FBgn0004598). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:16267121..16275816. It has the cytological map location 14C1-14C2. There is experimental evidence that it has the molecular function</span>: serine-type endopeptidase activity. It is reported to be involved in the biological process</span>: proteolysis. 10 alleles are reported. No phenotypic data is available. It has 9 annotated transcripts and 9 annotated polypeptides. [FlyBase]
  • The gene Furin 2 is referred to in FlyBase by the symbol Dmel\Fur2 (CG18734, FBgn0004598). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:16267121..16275816. It has the cytological map location 14C1-14C2. There is experimental evidence that it has the molecular function</span>: serine-type endopeptidase activity. It is reported to be involved in the biological process</span>: proteolysis. 10 alleles are reported. No phenotypic data is available. It has 9 annotated transcripts and 9 annotated polypeptides. [FlyBase]
  • The gene Furin 2 is referred to in FlyBase by the symbol Dmel\Fur2 (CG18734, FBgn0004598). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:16267121..16275816. It has the cytological map location 14C1-14C2. There is experimental evidence that it has the molecular function</span>: serine-type endopeptidase activity. It is reported to be involved in the biological process</span>: proteolysis. 10 alleles are reported. No phenotypic data is available. It has 9 annotated transcripts and 9 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1682 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNTTRSSRV TIGRIGTTPQ ITDPWSSGLE KQRPSRCGGP KSLAEPTYRK IGRRKMMLHM  60
   61 RVHDPGTTVT QRAKETATAK LNRIYLCTFN RMAQSCIYFV LFLVILSPNT SCALRSSAGE 120
  121 TQNYVGILSN DSATTTYDVS SLHSSRRTNP PSSSSSSSSN VDVDYRNDRE LHKVDLVGLG 180
  181 GERAGQAETI SGGKYDYNYE NTHTNASAKD EIVERQSNSL DFDGVDMFGA FSIPEEAIYT 240
  241 NEFAVNIPAG KQMADVIATK HGFINRGQIG SLDNYYLFQH HHVSKRSLRS SRKHQGALKS 300
  301 ENEVKWMQQQ HEKVRRKRDG PYQDLPTYSP YNLLRQHGGY VVDPNPHLSF SPESISLASH 360
  361 SQRMEYRDVS SHFIFPDPLF KEQWYLVSKN GGAKDGLDMN VGPAWQKGYT GKGVVVSILD 420
  421 DGIQTNHPDL AQNYDPEASF DINGNDSDPT PQDNGDNKHG TRCAGEVAAV AFNNFCGVGV 480
  481 AYNASIGGVR MLDGKVNDVV EAQALSLNPS HIDIYSASWG PEDDGSTVDG PGPLARRAFI 540
  541 YGVTSGRQGK GSIFVWASGN GGRYTDSCNC DGYTNSIFTL SISSATQAGF KPWYLEECSS 600
  601 TLATTYSSGT PGHDKSVATV DMDGSLRPDH ICTVEHTGTS ASAPLAAGIC ALALEANPEL 660
  661 TWRDMQYLVV YTSRPAPLEK ENGWTLNGVK RKYSHKFGYG LMDAGAMVSL AEQWTSVPPQ 720
  721 HICKSRENNE DRKIDGAYGS TLSTHMDVNG CAGTINEVRY LEHVQCRITL RFFPRGNLRI 780
  781 LLTSPMGTTS TLLFERPRDI VKSNFDDWPF LSVHFWGEKA EGRWTLQVIN GGRRRVNQPG 840
  841 ILSKWQLIFY GTSTQPMRLK SELLNSSPQL RSPSSSNPFL FPSASNIGQP ANEGGNFNTD 900
  901 SFASYLNYQN IFSSAGSDPE PATATLDGQN VTAAIAGGSS AESLGFTASA AQLVAAPETR 960
  961 DGDKKILHSC DAECDSSGCY GRGPTQCVAC SHYRLDNTCV SRCPPRSFPN QVGICWPCHD1020
 1021 TCETCAGAGP DSCLTCAPAH LHVIDLAVCL QFCPDGYFEN SRNRTCVPCE PNCASCQDHP1080
 1081 EYCTSCDHHL VMHEHKCYSA CPLDTYETED NKCAFCHSTC ATCNGPTDQD CITCRSSRYA1140
 1141 WQNKCLISCP DGFYADKKRL ECMPCQEGCK TCTSNGVCSE CLQNWTLNKR DKCIVSGSEG1200
 1201 CSESEFYSQV EGQCRPCHAS CGSCNGPADT SCTSCPPNRL LEQSRCVSGC REGFFVEAGS1260
 1261 LCSPCLHTCS QCVSRTNCSN CSKGLELQNG ECRTTCADGY YSDRGICAKC YLSCHTCSGP1320
 1321 RRNQCVQCPA GWQLAAGECH PECPEGFYKS DFGCQKCHHY CKTCNDAGPL ACTSCPPHSM1380
 1381 LDGGLCMECL SSQYYDTTSA TCKTCHDSCR SCFGPGQFSC KGCVPPLHLD QLNSQCVSCC1440
 1441 QNQTLAEKTS SAACCNCDGE TGECKATSTG GKRRTVVGSG SAYKSSESKH GSFENDGNAR1500
 1501 EFVLRLDSPL TAITAIAVAI CLLIITIFSI IFAVLQRNSN HVSRNSVRYR KIANTSSGRR1560
 1561 KNLSAKPTSD ARFIFNIGED DDTDGDNSDD ELDGNVGTDI NNRIVYDRKG NDHGHEFYIE1620
 1621 STNDIDAIEF HCNGAGAQKA ETQLQRCNAN GDDDDILHYD RHTNAERKNH PSSTTSRTNI1680
 1681 RS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..214] deduced N/A No confident structure predictions are available.
    2 View Details [215..326] PSI-BLAST 23.0 Prohormone convertase 1 pro-domain
    3 View Details [327..369] PSI-BLAST 58.522879 No description for 2e1pA was found.
    4 View Details [370..832] PSI-BLAST 161.0 Furin, C-terminal domain; Furin, N-terminal domain
    5 View Details [833..896] deduced N/A No confident structure predictions are available.
    6 View Details [897..1426] PSI-BLAST 11.154902 Crystal structure of ErbB4/HER4 extracellular domain
    7 View Details [1427..1581] PSI-BLAST 7.522879 Strucuture of the C-terminal domain of human thrombospondin-2
    8 View Details [1582..1682] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • peptidase activity
    		•  4.77677490610016 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  4.40501322467328 bayes_pls_golite062009
  • serine hydrolase activity
    		•  4.30899317351154 bayes_pls_golite062009
  • serine-type peptidase activity
    		•  4.29545891350519 bayes_pls_golite062009
  • nerve growth factor binding
    		•  4.00876127913772 bayes_pls_golite062009
  • endopeptidase activity
    		•  3.83336601331518 bayes_pls_golite062009
  • serine-type endopeptidase activity
    		•  3.71508033196614 bayes_pls_golite062009
  • growth factor binding
    		•  2.60157910925561 bayes_pls_golite062009
  • hydrolase activity
    		•  2.05732080397524 bayes_pls_golite062009
  • neurotrophin binding
    		•  1.71684037453881 bayes_pls_golite062009
  • receptor binding
    		•  1.53429624476134 bayes_pls_golite062009
  • eukaryotic cell surface binding
    		•  1.50287724152407 bayes_pls_golite062009
  • binding
    		•  1.28749522568113 bayes_pls_golite062009
  • catalytic activity
    		•  0.597535457699629 bayes_pls_golite062009
  • peptide binding
    		•  0.567438185669089 bayes_pls_golite062009
  • protein binding
    		•  0.480761501301928 bayes_pls_golite062009
  • exopeptidase activity
    		•  0.42083764849682 bayes_pls_golite062009
  • low-density lipoprotein receptor binding
    		•  0.367152941142039 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  0.22219445619715 bayes_pls_golite062009
  • lipoprotein receptor binding
    		•  0.21778182396266 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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