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Protein Overview: kat80-PA, kat80-PB

General Information:
Name(s) found: kat80-PA / FBpp0074026 [FlyBase]
kat80-PB / FBpp0074025 [FlyBase]
Description(s) found:
Found 34 descriptions.
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  • The gene katanin 80 is referred to in FlyBase by the symbol Dmel\kat80 (CG13956, FBgn0040207). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:16161038..16170213. It has the cytological map location 14B7. Based on sequence similarity, it is predicted to have molecular function</span>: microtubule binding. Based on sequence similarity, it is predicted to be involved in the biological process</span>: microtubule severing; microtubule-based process. 6 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene katanin 80 is referred to in FlyBase by the symbol Dmel\kat80 (CG13956, FBgn0040207). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:16161038..16170213. It has the cytological map location 14B7. Based on sequence similarity, it is predicted to have molecular function</span>: microtubule binding. Based on sequence similarity, it is predicted to be involved in the biological process</span>: microtubule severing; microtubule-based process. 6 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 819 amino acids

    Gene Ontology:
    Cellular Component: katanin complex [ISS][NAS]
    Biological Process: microtubule severing [ISS][NAS]
    microtubule-based process [ISS]
    Molecular Function: microtubule binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALPRKLISK IYDIKAHDSR VTSLDLGETG RVLVTGGEDR NVNLWAIGQN ECFMSLTGHN  60
   61 RSIDCVRFAY KDNFVYSADD IGIIRRWDLN SQKIYSTLNG HMKSVRTLDF NPSGEYVVSG 120
  121 SNDTTVRLWD VQNENNCIKV CRGHMSHVNS VKFSPDGLWI ASAGLEGSIL IWDIRKSKQI 180
  181 MEFIADPPVT AITCVQFHPF EFLLAAGRVD GTVSIYDLEH QQLVSQTTHF YGQAIRCITF 240
  241 SDNGECLFVG SSSGISVIGW EPDRELDHIK STWSSLADMK VVNNKLICGC HEIDTVSINT 300
  301 ISLDRVIPFY QPPNSLPNFK HNSTNRKSFT RGNQKFRLSV GGAKPAQVQE EHEGDKSGLS 360
  361 SPNYSLEVVN EAVLESAETS PMSSLPPVHL ASMAGSSADL APHHVVYGGA IDSALRQGKY 420
  421 SRVPDNMASY GSSYGAIDTR LMSLNEPSSL HKPDIYNLYP LDKNEEADVQ QLEFNLNDSN 480
  481 PPILNNYDNY EMAEDFPVNQ NLNYITNNYK PVPATSTINA SSKSIKKTTT TTLHKRTTNN 540
  541 MAGAKQTSTG IFGGSKLSQV SSVSSMELHK LDDNMVLKKS SSSNVVNKNK RPMGSAQSQF 600
  601 SKENNQQKNI NVEIITKPPM RSRTTLDMRT SHQAKTQEKQ IHQQQPMNNR IIMDDHDFDM 660
  661 LSRSHEAVLQ ELSNRQSSLD LLRHATRSHD VLGALRQARS CGKSIFIDLL GAILEKPSSW 720
  721 NLDFCMFVLP EIYELLQSQH KFHFTRACDT LRIILSNFLP TIQENLDSWA ANGLGVDVTR 780
  781 EDRQRKCAEC QRWLLQIKNL PESTHFGSTL SQLQNIIIF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..80] PSI-BLAST 77.221849 PAF-AH Holoenzyme: Lis1/Alfa2
    2 View Details [81..198] PSI-BLAST 6.522879 No description for 2ojhA was found.
    3 View Details [199..526] PSI-BLAST 15.69897 Crystal Structure analysis of the beta-propeller protein Ski8p
    4 View Details [527..573] PSI-BLAST 27.522879 Crystal Structure Of The C-Terminal WD40 Domain Of Sif2
    5 View Details [574..819] MSA 1.071942 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • actin binding
    		•  3.86142918698875 bayes_pls_golite062009
  • acetyltransferase activity
    		•  3.85374902981345 bayes_pls_golite062009
  • acyltransferase activity
    		•  3.35098520158193 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  3.31615347567536 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  3.14917998298348 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.1056443224755 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  3.00422709839505 bayes_pls_golite062009
  • tubulin binding
    		•  2.76945430061825 bayes_pls_golite062009
  • microtubule binding
    		•  2.72684103222924 bayes_pls_golite062009
  • dynein binding
    		•  2.54821997913979 bayes_pls_golite062009
  • binding
    		•  2.42570478946173 bayes_pls_golite062009
  • protein binding
    		•  2.26925404328312 bayes_pls_golite062009
  • actin filament binding
    		•  2.0735069176589 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  2.0212765804548 bayes_pls_golite062009
  • dynactin binding
    		•  1.85146647785657 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.4991068812591 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.42548927439572 bayes_pls_golite062009
  • microtubule plus-end binding
    		•  1.01166033978052 bayes_pls_golite062009
  • myosin binding
    		•  0.989691178611801 bayes_pls_golite062009
  • DNA binding
    		•  0.963493426709289 bayes_pls_golite062009
  • transporter activity
    		•  0.692270256454453 bayes_pls_golite062009
  • histone binding
    		•  0.685319917508843 bayes_pls_golite062009
  • protein kinase activity
    		•  0.544118712921054 bayes_pls_golite062009
  • dynein intermediate chain binding
    		•  0.443846546939402 bayes_pls_golite062009
  • transcription factor activity
    		•  0.435575551078191 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.367729389382533 bayes_pls_golite062009
  • signal transducer activity
    		•  0.367729389382533 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.350063170588591 bayes_pls_golite062009
  • snoRNA binding
    		•  0.347797037104681 bayes_pls_golite062009
  • kinase activity
    		•  0.338000962379752 bayes_pls_golite062009
  • transcription initiation factor activity
    		•  0.319410949467982 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  0.311523647180993 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.298055197418849 bayes_pls_golite062009
  • structural molecule activity
    		•  0.254012051644049 bayes_pls_golite062009
  • transcription factor binding
    		•  0.136928257321035 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.121183207943714 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.118975415284669 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.0803897416817422 bayes_pls_golite062009
    		• 0.0248988265652406 bayes_pls_golite062009
  • myosin II binding
    		•  0.0145748031956598 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.00585398682921312 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle