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Protein Overview: CG8909-PB

General Information:
Name(s) found: CG8909-PB / FBpp0073931 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG8909 (CG8909, FBgn0030706). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:15805013..15814812. It has the cytological map location 14A1. Based on sequence similarity, it is predicted to have molecular function</span>: low-density lipoprotein receptor activity. The biological processes in which it is involved are not known. 5 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 2009 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEA]
    Biological Process: NONE FOUND
    Molecular Function: calcium ion binding [IEA]
    low-density lipoprotein receptor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYLTAFPFWP LVCFVWLCLG LGDLTKTAVK RNAPHYGIHP TNALGRWDWN KHKQLHSDAR  60
   61 IGHLEAGNES REDQLSEELS KFGEKLFPVS NYPPYQQNNE DSQEVHHSGE GRLHTMESSV 120
  121 PSKTRISGGT NSNDTPKFRN IGAQRGRTEI AGIRETDRIS SRGRDGFIGG PSNKQKPFRV 180
  181 NLAVLVQDDP SQPGETYSNC QNSNESDENC NPEEDAVPNL QRDCEKTGIH VMCPRTFRCI 240
  241 SKYWLCDGDD DCGDYSDETH CGARTNCTDD QFECLNGFCI PRTWVCDGEN DCKDFSDETH 300
  301 CNRTTCTDEH FTCNDGYCIS LAFRCDGEHD CNDNSDELKC AAVINSCPEG EFKCRGGLGG 360
  361 AGGPSGQCIL NRFRCDGDND CGDWSDEENC PQKPSLCTSN EYKCADGTCI PKRWKCDKEQ 420
  421 DCDGGEDEND CGSLGSEHPL TCGSDEFTCN NGRCILKTWL CDGYPDCAAG EDEVECHLQC 480
  481 DLGQFLCPTK QNLTNLKICV HQKHICDGHN ECPAGEDEAD CPKERKCSEP SPCEQLCIET 540
  541 TAGSNECACR LGYVMDKNKV NCTDIDECQY LTSPVCSQKC HNTMGSFKCS CETGYILRPD 600
  601 LRSCKALGGA MTLLVANRWD IRRVTLSNNR YSAIVKGLHN AIALDFHHRK GLMFWSDVST 660
  661 DVIKMVYMNG TRVRDVIKWG LESPGGIAVD WIHDLLFWTD SGTRRVEVSN FQGNLRTVIA 720
  721 SYDLDKPRAI VVHPGEALAF WSDWGPNPKI ERAYMDGTQR KVIISKGVTW PNGLAIDFPN 780
  781 SKIYWADAKQ HAIECSNLDG SDRNKILSTH LPHPFALTLF EDTMYWTDWN TKTVSAADKI 840
  841 TGKEFRAVHE NFHFPMDIHA YHPARQPEYA DRCQKDRRGL RGGCSHLCLP NKTSRRCGCP 900
  901 IGLSLKEDGK TCKSTADKLV LVARRKDIRL RHLRDNQADP NDVDMIVPLD NLKHAVALDW 960
  961 CSDTDFIYWT DVERSTINKA HLNGSYQQRV VHSNLVSPVG LALDWITDKL YWTDPSTNRI1020
 1021 EVATTNGKMR TLLIWEKLYK PRDIVVNPIE GFMFWSDWGD DPMIERANMD GHERVTITSK1080
 1081 KLIYPNGLAI DYEKSKIYFV DGGTKTLENM NFDGSGRQVI LNGLGHPFGL DVNEGRVFWT1140
 1141 DWDTKSVMSA NKLTGKDTNV IIANSTDLMD IRVFHRTRRR IFNACDKLNG GCSHLCLLNP1200
 1201 TSYTCACTVG VQLKEDRHTC SEGPTQYILF AHRIDIRQIS LDFDHLIDVV LPLPPISNAV1260
 1261 ALDVDRKTGY IYWSDTIENV IMSSSPDGLH VQKIVGDSLE NPDGLVVDSI GRTIYWADAG1320
 1321 RHTIEVASLD GSNRHVIAYK DLESPRGLAL DYEAGLLFWT DWGHYRKIER SHLDGNERSR1380
 1381 IVTANLGWPN GLSLDLKSKR IYWVDARLKT IDSCDYTGNQ RKLIMSSLHH PYALALSDDN1440
 1441 IYWTDWKSKA LHMTERRNIS AKRDIITNID GLMDIKIIYQ NQNQSTMKNA CGNNNGNCSH1500
 1501 LCLRNPSGYS CQCPIGLRLR QNSTTQCQNL PEDYLLIALR SGIGMISLNS GDFMDVVLPI1560
 1561 NGVHGAVVLD YHYRKNLLFF ADVNLDVIRR VNLLNLTESK VIVGTDVLTP NGIAVDWIAD1620
 1621 NLYWSDTDRK LIEVSRLDGS CRKRIVEDNL GDPRSLIVHP KKAYLFWSDW SSPAKIERSY1680
 1681 LDGSNRTVII TSGIGFPTGL TIDFTNRRLL WADALEDNIG QVDFNGKRRQ TIVPYAPHPF1740
 1741 GLTLFENSIF WTDWYNKSVY RSQKLARSGY GNPFEVRDAL SGALDIRAVS LSRQPKSVNH1800
 1801 CAQDNGGCTH LCLNRNVDYV CACPDVMDPK DVACSIKPKV LVHANLENDQ LLEYSDESTD1860
 1861 DSTPPELLGE SNDHGDDGHT KKSDQEREFF VLVALGVVIV MVVIIILVIF MLAFNTSKKK1920
 1921 NKRNSRGSSR SVLTFSNPNY NVDGTPMEPK TNIWKRFKYD KTHQERAGVY EERSLTTETA1980
 1981 SSSLFVPTPS PMASPSTKTI QLTTLSTIT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..132] PSI-BLAST 7.0 Ligand-binding domain of low-density lipoprotein receptor
    2 View Details [133..233] deduced N/A No confident structure predictions are available.
    3 View Details [234..915] PSI-BLAST 156.0 Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
    4 View Details [916..1167] PSI-BLAST 75.0 Crystal structure of Nidogen/Laminin Complex
    5 View Details [1168..1470] FFAS03 3.66 Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
    6 View Details [1471..1516] PSI-BLAST 7.0 Solution structure of the LA7-EGFA pair from the LDL receptor
    7 View Details [1517..1888] PSI-BLAST 105.0 Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains
    8 View Details [1889..2009] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • lipoprotein binding
    		•  7.11457542319896 bayes_pls_golite062009
  • low-density lipoprotein binding
    		•  6.26591728596226 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  5.08521994085381 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  4.67569879681015 bayes_pls_golite062009
  • receptor activity
    		•  4.61995366997272 bayes_pls_golite062009
  • receptor binding
    		•  4.60755835611133 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  4.5269049952785 bayes_pls_golite062009
  • growth factor activity
    		•  4.38305031783896 bayes_pls_golite062009
  • low-density lipoprotein receptor activity
    		•  3.65371958920557 bayes_pls_golite062009
  • very-low-density lipoprotein receptor activity
    		•  3.62116221247038 bayes_pls_golite062009
  • very-low-density lipoprotein binding
    		•  3.62116221247038 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  3.23778562911102 bayes_pls_golite062009
  • extracellular matrix structural constituent
    		•  3.15905968809584 bayes_pls_golite062009
  • binding
    		•  2.97929690141955 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  2.26126081873043 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.16844098063599 bayes_pls_golite062009
  • protein binding
    		•  1.97546801934296 bayes_pls_golite062009
  • lipoprotein receptor activity
    		•  1.88531190199688 bayes_pls_golite062009
  • heparin binding
    		•  1.85175622678943 bayes_pls_golite062009
  • transcription factor binding
    		•  1.71838409809333 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.61057978332614 bayes_pls_golite062009
  • lipoprotein transporter activity
    		•  1.44629975873627 bayes_pls_golite062009
  • transporter activity
    		•  1.44005597324471 bayes_pls_golite062009
  • collagen binding
    		•  1.3611207932336 bayes_pls_golite062009
  • pattern binding
    		•  1.26957983931218 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.21257866727 bayes_pls_golite062009
  • signal transducer activity
    		•  1.21257866727 bayes_pls_golite062009
  • polysaccharide binding
    		•  1.11978732751628 bayes_pls_golite062009
  • protein kinase activity
    		•  1.00235965838736 bayes_pls_golite062009
  • lipoprotein receptor binding
    		•  0.9511222573686 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.833222558099761 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.741912411452008 bayes_pls_golite062009
  • carbohydrate binding
    		•  0.72748768329894 bayes_pls_golite062009
  • kinase activity
    		•  0.692244195382463 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.67022333774569 bayes_pls_golite062009
  • apolipoprotein binding
    		•  0.598690562495919 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  0.44857826904729 bayes_pls_golite062009
  • extracellular matrix binding
    		•  0.3265100728106 bayes_pls_golite062009
  • sterol transporter activity
    		•  0.2876250672781 bayes_pls_golite062009
  • Wnt receptor activity
    		•  0.13279851428273 bayes_pls_golite062009
  • glycoprotein binding
    		•  0.128291636237359 bayes_pls_golite062009
    4
    Term Confidence Notes
  • lipoprotein binding
    		•  7.11457542319896 bayes_pls_golite062009
  • low-density lipoprotein binding
    		•  6.26591728596226 bayes_pls_golite062009
  • receptor activity
    		•  4.61995366997272 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  4.5269049952785 bayes_pls_golite062009
  • signal transducer activity
    		•  3.83715772816989 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.83715772816989 bayes_pls_golite062009
  • low-density lipoprotein receptor activity
    		•  3.65371958920557 bayes_pls_golite062009
  • very-low-density lipoprotein binding
    		•  3.62116221247038 bayes_pls_golite062009
  • very-low-density lipoprotein receptor activity
    		•  3.62116221247038 bayes_pls_golite062009
  • binding
    		•  3.10919144943954 bayes_pls_golite062009
  • growth factor activity
    		•  2.17932161987798 bayes_pls_golite062009
  • protein binding
    		•  2.11668700345827 bayes_pls_golite062009
  • receptor binding
    		•  2.00382722979859 bayes_pls_golite062009
  • lipoprotein receptor activity
    		•  1.88531190199688 bayes_pls_golite062009
  • lipoprotein transporter activity
    		•  1.44629975873627 bayes_pls_golite062009
  • transporter activity
    		•  1.44005597324471 bayes_pls_golite062009
  • collagen binding
    		•  1.3611207932336 bayes_pls_golite062009
  • lipoprotein receptor binding
    		•  0.9511222573686 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.833222558099761 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  0.748938657375399 bayes_pls_golite062009
  • apolipoprotein binding
    		•  0.598690562495919 bayes_pls_golite062009
  • extracellular matrix binding
    		•  0.3265100728106 bayes_pls_golite062009
  • sterol transporter activity
    		•  0.2876250672781 bayes_pls_golite062009
  • Wnt receptor activity
    		•  0.13279851428273 bayes_pls_golite062009
    5
    Term Confidence Notes
  • lipoprotein binding
    		•  6.51440111037193 bayes_pls_golite062009
  • low-density lipoprotein binding
    		•  5.66210924811327 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  4.48681564258554 bayes_pls_golite062009
  • receptor activity
    		•  4.28360316651781 bayes_pls_golite062009
  • receptor binding
    		•  4.27252497280864 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  4.19315346907577 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  4.10601194625533 bayes_pls_golite062009
  • growth factor activity
    		•  3.99323701198118 bayes_pls_golite062009
  • very-low-density lipoprotein receptor activity
    		•  3.0315455445332 bayes_pls_golite062009
  • very-low-density lipoprotein binding
    		•  3.0315455445332 bayes_pls_golite062009
  • extracellular matrix structural constituent
    		•  3.02903850477823 bayes_pls_golite062009
  • low-density lipoprotein receptor activity
    		•  3.00304002443591 bayes_pls_golite062009
  • binding
    		•  2.882098367609 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  2.71860873435964 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.09865601789668 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  2.00793364644633 bayes_pls_golite062009
  • protein binding
    		•  1.82603764519822 bayes_pls_golite062009
  • heparin binding
    		•  1.57277508987686 bayes_pls_golite062009
  • transcription factor binding
    		•  1.49219400742679 bayes_pls_golite062009
  • transporter activity
    		•  1.43442675517178 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.34116610395358 bayes_pls_golite062009
  • collagen binding
    		•  1.24355574661219 bayes_pls_golite062009
  • lipoprotein receptor activity
    		•  1.23102732859636 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.21226570895943 bayes_pls_golite062009
  • signal transducer activity
    		•  1.21226570895943 bayes_pls_golite062009
  • lipoprotein transporter activity
    		•  1.0974112687996 bayes_pls_golite062009
  • pattern binding
    		•  1.05555020412008 bayes_pls_golite062009
  • protein kinase activity
    		•  0.977135636901261 bayes_pls_golite062009
  • polysaccharide binding
    		•  0.885698451656522 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.813155897899544 bayes_pls_golite062009
  • lipoprotein receptor binding
    		•  0.740003544151054 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.726675541334001 bayes_pls_golite062009
  • kinase activity
    		•  0.682621677369398 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.668097370682722 bayes_pls_golite062009
  • carbohydrate binding
    		•  0.574591146245624 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  0.346221179082765 bayes_pls_golite062009
  • extracellular matrix binding
    		•  0.174246036561422 bayes_pls_golite062009
  • apolipoprotein binding
    		•  0.135033024827723 bayes_pls_golite062009
  • sterol transporter activity
    		•  0.0947574599063101 bayes_pls_golite062009
  • catalytic activity
    		•  0.0197550253779933 bayes_pls_golite062009
    6
    Term Confidence Notes
  • ErbB-2 class receptor binding
    		•  5.08521994085381 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  4.67569879681015 bayes_pls_golite062009
  • receptor binding
    		•  4.60755835611133 bayes_pls_golite062009
  • growth factor activity
    		•  4.38305031783896 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  3.23778562911102 bayes_pls_golite062009
  • extracellular matrix structural constituent
    		•  3.15905968809584 bayes_pls_golite062009
  • binding
    		•  2.97929690141955 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  2.26126081873043 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.16844098063599 bayes_pls_golite062009
  • protein binding
    		•  1.97546801934296 bayes_pls_golite062009
  • heparin binding
    		•  1.85175622678943 bayes_pls_golite062009
  • transcription factor binding
    		•  1.71838409809333 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.61057978332614 bayes_pls_golite062009
  • pattern binding
    		•  1.26957983931218 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.21257866727 bayes_pls_golite062009
  • signal transducer activity
    		•  1.21257866727 bayes_pls_golite062009
  • polysaccharide binding
    		•  1.11978732751628 bayes_pls_golite062009
  • protein kinase activity
    		•  1.00235965838736 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.741912411452008 bayes_pls_golite062009
  • carbohydrate binding
    		•  0.72748768329894 bayes_pls_golite062009
  • kinase activity
    		•  0.692244195382463 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.67022333774569 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  0.44857826904729 bayes_pls_golite062009
  • glycoprotein binding
    		•  0.128291636237359 bayes_pls_golite062009
    7 No functions predicted.
    8 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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