| Protein: | CG8909-PB |
| Organism: | Drosophila melanogaster |
| Length: | 2009 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CG8909-PB.
| Description | E-value | Query Range |
Subject Range |
|
|
1739.0 | [0..162] | [1974..178] |
|
Region A: Residues: [1-132] |
1 11 21 31 41 51
| | | | | |
1 MYLTAFPFWP LVCFVWLCLG LGDLTKTAVK RNAPHYGIHP TNALGRWDWN KHKQLHSDAR 60
61 IGHLEAGNES REDQLSEELS KFGEKLFPVS NYPPYQQNNE DSQEVHHSGE GRLHTMESSV 120
121 PSKTRISGGT NS
|
| Detection Method: |  |
| Confidence: | 7.0 |
| Match: | 1f5yA |
| Description: | Ligand-binding domain of low-density lipoprotein receptor |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [133-233] |
1 11 21 31 41 51
| | | | | |
1 NDTPKFRNIG AQRGRTEIAG IRETDRISSR GRDGFIGGPS NKQKPFRVNL AVLVQDDPSQ 60
61 PGETYSNCQN SNESDENCNP EEDAVPNLQR DCEKTGIHVM C
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [234-915] |
1 11 21 31 41 51
| | | | | |
1 PRTFRCISKY WLCDGDDDCG DYSDETHCGA RTNCTDDQFE CLNGFCIPRT WVCDGENDCK 60
61 DFSDETHCNR TTCTDEHFTC NDGYCISLAF RCDGEHDCND NSDELKCAAV INSCPEGEFK 120
121 CRGGLGGAGG PSGQCILNRF RCDGDNDCGD WSDEENCPQK PSLCTSNEYK CADGTCIPKR 180
181 WKCDKEQDCD GGEDENDCGS LGSEHPLTCG SDEFTCNNGR CILKTWLCDG YPDCAAGEDE 240
241 VECHLQCDLG QFLCPTKQNL TNLKICVHQK HICDGHNECP AGEDEADCPK ERKCSEPSPC 300
301 EQLCIETTAG SNECACRLGY VMDKNKVNCT DIDECQYLTS PVCSQKCHNT MGSFKCSCET 360
361 GYILRPDLRS CKALGGAMTL LVANRWDIRR VTLSNNRYSA IVKGLHNAIA LDFHHRKGLM 420
421 FWSDVSTDVI KMVYMNGTRV RDVIKWGLES PGGIAVDWIH DLLFWTDSGT RRVEVSNFQG 480
481 NLRTVIASYD LDKPRAIVVH PGEALAFWSD WGPNPKIERA YMDGTQRKVI ISKGVTWPNG 540
541 LAIDFPNSKI YWADAKQHAI ECSNLDGSDR NKILSTHLPH PFALTLFEDT MYWTDWNTKT 600
601 VSAADKITGK EFRAVHENFH FPMDIHAYHP ARQPEYADRC QKDRRGLRGG CSHLCLPNKT 660
661 SRRCGCPIGL SLKEDGKTCK ST
|
| Detection Method: | |
| Confidence: | 156.0 |
| Match: | 1n7dA |
| Description: | Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| lipoprotein binding | 7.11457542319896 | bayes_pls_golite062009 |
| low-density lipoprotein binding | 6.26591728596226 | bayes_pls_golite062009 |
| ErbB-2 class receptor binding | 5.08521994085381 | bayes_pls_golite062009 |
| ErbB-3 class receptor binding | 4.67569879681015 | bayes_pls_golite062009 |
| receptor activity | 4.61995366997272 | bayes_pls_golite062009 |
| receptor binding | 4.60755835611133 | bayes_pls_golite062009 |
| transmembrane receptor activity | 4.5269049952785 | bayes_pls_golite062009 |
| growth factor activity | 4.38305031783896 | bayes_pls_golite062009 |
| low-density lipoprotein receptor activity | 3.65371958920557 | bayes_pls_golite062009 |
| very-low-density lipoprotein receptor activity | 3.62116221247038 | bayes_pls_golite062009 |
| very-low-density lipoprotein binding | 3.62116221247038 | bayes_pls_golite062009 |
| epidermal growth factor receptor binding | 3.23778562911102 | bayes_pls_golite062009 |
| extracellular matrix structural constituent | 3.15905968809584 | bayes_pls_golite062009 |
| binding | 2.97929690141955 | bayes_pls_golite062009 |
| glycosaminoglycan binding | 2.26126081873043 | bayes_pls_golite062009 |
| transcription regulator activity | 2.16844098063599 | bayes_pls_golite062009 |
| protein binding | 1.97546801934296 | bayes_pls_golite062009 |
| lipoprotein receptor activity | 1.88531190199688 | bayes_pls_golite062009 |
| heparin binding | 1.85175622678943 | bayes_pls_golite062009 |
| transcription factor binding | 1.71838409809333 | bayes_pls_golite062009 |
| transcription cofactor activity | 1.61057978332614 | bayes_pls_golite062009 |
| lipoprotein transporter activity | 1.44629975873627 | bayes_pls_golite062009 |
| transporter activity | 1.44005597324471 | bayes_pls_golite062009 |
| collagen binding | 1.3611207932336 | bayes_pls_golite062009 |
| pattern binding | 1.26957983931218 | bayes_pls_golite062009 |
| molecular transducer activity | 1.21257866727 | bayes_pls_golite062009 |
| signal transducer activity | 1.21257866727 | bayes_pls_golite062009 |
| polysaccharide binding | 1.11978732751628 | bayes_pls_golite062009 |
| protein kinase activity | 1.00235965838736 | bayes_pls_golite062009 |
| lipoprotein receptor binding | 0.9511222573686 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.833222558099761 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 0.741912411452008 | bayes_pls_golite062009 |
| carbohydrate binding | 0.72748768329894 | bayes_pls_golite062009 |
| kinase activity | 0.692244195382463 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 0.67022333774569 | bayes_pls_golite062009 |
| apolipoprotein binding | 0.598690562495919 | bayes_pls_golite062009 |
| cell adhesion molecule binding | 0.44857826904729 | bayes_pls_golite062009 |
| extracellular matrix binding | 0.3265100728106 | bayes_pls_golite062009 |
| sterol transporter activity | 0.2876250672781 | bayes_pls_golite062009 |
| Wnt receptor activity | 0.13279851428273 | bayes_pls_golite062009 |
| glycoprotein binding | 0.128291636237359 | bayes_pls_golite062009 |
|
Region A: Residues: [916-1167] |
1 11 21 31 41 51
| | | | | |
1 ADKLVLVARR KDIRLRHLRD NQADPNDVDM IVPLDNLKHA VALDWCSDTD FIYWTDVERS 60
61 TINKAHLNGS YQQRVVHSNL VSPVGLALDW ITDKLYWTDP STNRIEVATT NGKMRTLLIW 120
121 EKLYKPRDIV VNPIEGFMFW SDWGDDPMIE RANMDGHERV TITSKKLIYP NGLAIDYEKS 180
181 KIYFVDGGTK TLENMNFDGS GRQVILNGLG HPFGLDVNEG RVFWTDWDTK SVMSANKLTG 240
241 KDTNVIIANS TD
|
| Detection Method: | |
| Confidence: | 75.0 |
| Match: | 1npeA |
| Description: | Crystal structure of Nidogen/Laminin Complex |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| lipoprotein binding | 7.11457542319896 | bayes_pls_golite062009 |
| low-density lipoprotein binding | 6.26591728596226 | bayes_pls_golite062009 |
| receptor activity | 4.61995366997272 | bayes_pls_golite062009 |
| transmembrane receptor activity | 4.5269049952785 | bayes_pls_golite062009 |
| signal transducer activity | 3.83715772816989 | bayes_pls_golite062009 |
| molecular transducer activity | 3.83715772816989 | bayes_pls_golite062009 |
| low-density lipoprotein receptor activity | 3.65371958920557 | bayes_pls_golite062009 |
| very-low-density lipoprotein binding | 3.62116221247038 | bayes_pls_golite062009 |
| very-low-density lipoprotein receptor activity | 3.62116221247038 | bayes_pls_golite062009 |
| binding | 3.10919144943954 | bayes_pls_golite062009 |
| growth factor activity | 2.17932161987798 | bayes_pls_golite062009 |
| protein binding | 2.11668700345827 | bayes_pls_golite062009 |
| receptor binding | 2.00382722979859 | bayes_pls_golite062009 |
| lipoprotein receptor activity | 1.88531190199688 | bayes_pls_golite062009 |
| lipoprotein transporter activity | 1.44629975873627 | bayes_pls_golite062009 |
| transporter activity | 1.44005597324471 | bayes_pls_golite062009 |
| collagen binding | 1.3611207932336 | bayes_pls_golite062009 |
| lipoprotein receptor binding | 0.9511222573686 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.833222558099761 | bayes_pls_golite062009 |
| epidermal growth factor receptor binding | 0.748938657375399 | bayes_pls_golite062009 |
| apolipoprotein binding | 0.598690562495919 | bayes_pls_golite062009 |
| extracellular matrix binding | 0.3265100728106 | bayes_pls_golite062009 |
| sterol transporter activity | 0.2876250672781 | bayes_pls_golite062009 |
| Wnt receptor activity | 0.13279851428273 | bayes_pls_golite062009 |
|
Region A: Residues: [1168-1470] |
1 11 21 31 41 51
| | | | | |
1 LMDIRVFHRT RRRIFNACDK LNGGCSHLCL LNPTSYTCAC TVGVQLKEDR HTCSEGPTQY 60
61 ILFAHRIDIR QISLDFDHLI DVVLPLPPIS NAVALDVDRK TGYIYWSDTI ENVIMSSSPD 120
121 GLHVQKIVGD SLENPDGLVV DSIGRTIYWA DAGRHTIEVA SLDGSNRHVI AYKDLESPRG 180
181 LALDYEAGLL FWTDWGHYRK IERSHLDGNE RSRIVTANLG WPNGLSLDLK SKRIYWVDAR 240
241 LKTIDSCDYT GNQRKLIMSS LHHPYALALS DDNIYWTDWK SKALHMTERR NISAKRDIIT 300
301 NID
|
| Detection Method: | |
| Confidence: | 3.66 |
| Match: | 1n7dA |
| Description: | Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor |
| Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| lipoprotein binding | 6.51440111037193 | bayes_pls_golite062009 |
| low-density lipoprotein binding | 5.66210924811327 | bayes_pls_golite062009 |
| ErbB-2 class receptor binding | 4.48681564258554 | bayes_pls_golite062009 |
| receptor activity | 4.28360316651781 | bayes_pls_golite062009 |
| receptor binding | 4.27252497280864 | bayes_pls_golite062009 |
| transmembrane receptor activity | 4.19315346907577 | bayes_pls_golite062009 |
| ErbB-3 class receptor binding | 4.10601194625533 | bayes_pls_golite062009 |
| growth factor activity | 3.99323701198118 | bayes_pls_golite062009 |
| very-low-density lipoprotein receptor activity | 3.0315455445332 | bayes_pls_golite062009 |
| very-low-density lipoprotein binding | 3.0315455445332 | bayes_pls_golite062009 |
| extracellular matrix structural constituent | 3.02903850477823 | bayes_pls_golite062009 |
| low-density lipoprotein receptor activity | 3.00304002443591 | bayes_pls_golite062009 |
| binding | 2.882098367609 | bayes_pls_golite062009 |
| epidermal growth factor receptor binding | 2.71860873435964 | bayes_pls_golite062009 |
| transcription regulator activity | 2.09865601789668 | bayes_pls_golite062009 |
| glycosaminoglycan binding | 2.00793364644633 | bayes_pls_golite062009 |
| protein binding | 1.82603764519822 | bayes_pls_golite062009 |
| heparin binding | 1.57277508987686 | bayes_pls_golite062009 |
| transcription factor binding | 1.49219400742679 | bayes_pls_golite062009 |
| transporter activity | 1.43442675517178 | bayes_pls_golite062009 |
| transcription cofactor activity | 1.34116610395358 | bayes_pls_golite062009 |
| collagen binding | 1.24355574661219 | bayes_pls_golite062009 |
| lipoprotein receptor activity | 1.23102732859636 | bayes_pls_golite062009 |
| molecular transducer activity | 1.21226570895943 | bayes_pls_golite062009 |
| signal transducer activity | 1.21226570895943 | bayes_pls_golite062009 |
| lipoprotein transporter activity | 1.0974112687996 | bayes_pls_golite062009 |
| pattern binding | 1.05555020412008 | bayes_pls_golite062009 |
| protein kinase activity | 0.977135636901261 | bayes_pls_golite062009 |
| polysaccharide binding | 0.885698451656522 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.813155897899544 | bayes_pls_golite062009 |
| lipoprotein receptor binding | 0.740003544151054 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 0.726675541334001 | bayes_pls_golite062009 |
| kinase activity | 0.682621677369398 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 0.668097370682722 | bayes_pls_golite062009 |
| carbohydrate binding | 0.574591146245624 | bayes_pls_golite062009 |
| cell adhesion molecule binding | 0.346221179082765 | bayes_pls_golite062009 |
| extracellular matrix binding | 0.174246036561422 | bayes_pls_golite062009 |
| apolipoprotein binding | 0.135033024827723 | bayes_pls_golite062009 |
| sterol transporter activity | 0.0947574599063101 | bayes_pls_golite062009 |
| catalytic activity | 0.0197550253779933 | bayes_pls_golite062009 |
|
Region A: Residues: [1471-1516] |
1 11 21 31 41 51
| | | | | |
1 GLMDIKIIYQ NQNQSTMKNA CGNNNGNCSH LCLRNPSGYS CQCPIG
|
| Detection Method: | |
| Confidence: | 7.0 |
| Match: | 1xfeA |
| Description: | Solution structure of the LA7-EGFA pair from the LDL receptor |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| ErbB-2 class receptor binding | 5.08521994085381 | bayes_pls_golite062009 |
| ErbB-3 class receptor binding | 4.67569879681015 | bayes_pls_golite062009 |
| receptor binding | 4.60755835611133 | bayes_pls_golite062009 |
| growth factor activity | 4.38305031783896 | bayes_pls_golite062009 |
| epidermal growth factor receptor binding | 3.23778562911102 | bayes_pls_golite062009 |
| extracellular matrix structural constituent | 3.15905968809584 | bayes_pls_golite062009 |
| binding | 2.97929690141955 | bayes_pls_golite062009 |
| glycosaminoglycan binding | 2.26126081873043 | bayes_pls_golite062009 |
| transcription regulator activity | 2.16844098063599 | bayes_pls_golite062009 |
| protein binding | 1.97546801934296 | bayes_pls_golite062009 |
| heparin binding | 1.85175622678943 | bayes_pls_golite062009 |
| transcription factor binding | 1.71838409809333 | bayes_pls_golite062009 |
| transcription cofactor activity | 1.61057978332614 | bayes_pls_golite062009 |
| pattern binding | 1.26957983931218 | bayes_pls_golite062009 |
| molecular transducer activity | 1.21257866727 | bayes_pls_golite062009 |
| signal transducer activity | 1.21257866727 | bayes_pls_golite062009 |
| polysaccharide binding | 1.11978732751628 | bayes_pls_golite062009 |
| protein kinase activity | 1.00235965838736 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 0.741912411452008 | bayes_pls_golite062009 |
| carbohydrate binding | 0.72748768329894 | bayes_pls_golite062009 |
| kinase activity | 0.692244195382463 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 0.67022333774569 | bayes_pls_golite062009 |
| cell adhesion molecule binding | 0.44857826904729 | bayes_pls_golite062009 |
| glycoprotein binding | 0.128291636237359 | bayes_pls_golite062009 |
|
Region A: Residues: [1517-1888] |
1 11 21 31 41 51
| | | | | |
1 LRLRQNSTTQ CQNLPEDYLL IALRSGIGMI SLNSGDFMDV VLPINGVHGA VVLDYHYRKN 60
61 LLFFADVNLD VIRRVNLLNL TESKVIVGTD VLTPNGIAVD WIADNLYWSD TDRKLIEVSR 120
121 LDGSCRKRIV EDNLGDPRSL IVHPKKAYLF WSDWSSPAKI ERSYLDGSNR TVIITSGIGF 180
181 PTGLTIDFTN RRLLWADALE DNIGQVDFNG KRRQTIVPYA PHPFGLTLFE NSIFWTDWYN 240
241 KSVYRSQKLA RSGYGNPFEV RDALSGALDI RAVSLSRQPK SVNHCAQDNG GCTHLCLNRN 300
301 VDYVCACPDV MDPKDVACSI KPKVLVHANL ENDQLLEYSD ESTDDSTPPE LLGESNDHGD 360
361 DGHTKKSDQE RE
|
| Detection Method: | |
| Confidence: | 105.0 |
| Match: | 1ijqA |
| Description: | Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [1889-2009] |
1 11 21 31 41 51
| | | | | |
1 FFVLVALGVV IVMVVIIILV IFMLAFNTSK KKNKRNSRGS SRSVLTFSNP NYNVDGTPME 60
61 PKTNIWKRFK YDKTHQERAG VYEERSLTTE TASSSLFVPT PSPMASPSTK TIQLTTLSTI 120
121 T
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
