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Protein Overview: Ac13E-PB, Ac13E-PA

General Information:
Name(s) found: Ac13E-PB / FBpp0099492 [FlyBase]
Ac13E-PA / FBpp0073889 [FlyBase]
Description(s) found:
Found 32 descriptions.
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  • The gene Adenylyl cyclase 35C is referred to in FlyBase by the symbol Dmel\Ac13E (CG9210, FBgn0022710). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:15404909..15416196. It has the cytological map location 13C7-13C8. There is experimental evidence that it has the molecular function</span>: adenylate cyclase activity. There is experimental evidence that it is involved in the biological process</span>: cAMP biosynthetic process. 2 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene Adenylyl cyclase 35C is referred to in FlyBase by the symbol Dmel\Ac13E (CG9210, FBgn0022710). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:15404909..15416196. It has the cytological map location 13C7-13C8. There is experimental evidence that it has the molecular function</span>: adenylate cyclase activity. There is experimental evidence that it is involved in the biological process</span>: cAMP biosynthetic process. 2 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1690 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [UNKNOWN]
    Biological Process: cAMP biosynthetic process [IDA]
    intracellular signaling pathway [IEA]
    Molecular Function: adenylate cyclase activity [IDA][ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPPGVLVNDS RANSTDDIQI ALAPHIQTYL SQTGRRHSCC SVMLPVAFER AAAKSWLDPK  60
   61 FDSPVLEEQY QASVFPHVRM RYRFTLSYIL LCSLMWCLYF VVDGGSEDFW RPISSSFSML 120
  121 SLVTIMALCF THWDLYREHR TVTSAVTALL LCGASLAFLT YTGRAFSPLG HFAICLEIVL 180
  181 LIYTALPMPL WLGASTAISY SIAFEMVSHM VIGCSAIHGG PMHGGGGAAG GSGMEANGDP 240
  241 SNRILILRIM AHLSVHLVGV HVLIMNLVRM RGTFMKVGQN LLVRRQLEME KQLKEKMIHS 300
  301 VMPPKVADML LNEGGPSGLD AGGLPPESHY MRPRASNDVK SLFRPFHMHS MENVSILFAD 360
  361 IVGFTRMSST KTAEQLVEIL NDLFERFDDL CSLSGCEKIS TLGDCYYCVS GCPEPRADHA 420
  421 ICCVEMGLGM IDAMRCFDAQ RHEGVKMRVG VHTGTVLCGI VGTRRVKFDV WSNDVSLANK 480
  481 MESSGKPEQV HISQETSSFL GDAYYLEEGE EVFGHRTYFV VGRRRDFTRT NSLSPSMPAN 540
  541 ATGSSLLLPG AHGASLSQSA TNVSAVQPNV PPASPVGQLS SSLNPSPVLS MRPRLTSLSM 600
  601 KMRKKSQSRD RDVERGIIHP AAAGIPPVIV VRERPKIIIT TKSLPGSLDS DEQPPVSPPL 660
  661 LPPANPPAAE TRSKIKLKVW KIPRFLKRFE DLTNRSSCGG SSSAGHLDKE REREREKEKE 720
  721 ELHQHNQLNP EETLAFMDNQ MQNGNGCGYQ QLPVLVESNH RTQTLDIPAA RPVLHHAATS 780
  781 TALASSVLRS PEAGVSGGGG CCSPGQYSMY DDIIDVRSYI SQSRSDISPF GRSGSYRSQC 840
  841 GRQSTGGVNG AGPAGVGAEG RAGTSQTAPP VEQSPLPRPR ASTLATGRPT PNSLEPGPSS 900
  901 TSPCCLPAPG NSVGGGGIFP PTHSRQSSIC PSATSRKDSG IKSNSRRSSI QQQIYALNQT 960
  961 AISQHRVSGY FTSSTSSISN LGEVQGLGLP LAVQPPPPLL MPACSSQMAD PLAACLQQLR1020
 1021 KQSDLQLIRC VRDNARSQRS YLVKPPLRKF SLYFKSRQLE RDFRSKAHRF GAENETEGPP1080
 1081 TLATPRYNTY IDIFVGIAVY LCISVSLFLM TQNTVSPSFR LWVTLFSCFT GIQVFALFLF1140
 1141 TRQMCRRQSG SNVSNRFRSK STTSEDLERD ERGAAPGGRP HFESCADRIF EAISSWYPWH1200
 1201 ICLAVLMAMP VLLIIANFLL LDLEQLEAFE YHYGFLIFVC IVHFCNFTQL NCWVRNVLAF1260
 1261 LAALCFIGIA VSQLMVYSHN RSDQQQDQEA SNFIQEIKWF QDYHVEIYLD LLLILVLVWF1320
 1321 LNREFEIGYR LTFYGNAVAN QDKVRVQNMK NQADMLLHNI IPKHVAEHLK NTAKYSENHH1380
 1381 NIAIIFASIV NFNEMYDESY LGGKEFLRVL NELIGDFDEL LSRPEFRAVE KIKTIGSTFM1440
 1441 AASGLDPSHR GTGDEHIHTL MEFSIAMQEV VDAFNKDLLE FNLILRIGMN IGDVTAGVIG1500
 1501 TSKLYYDIWG DAVNVASRMD STGLPNRIQV GKDCLPFLTN RYEFEPRGSV YVKGKDHMEV1560
 1561 FLYTTRRDNP LDDDEADKVE QLGTKKMEHE GRDEDVVQGE QQAEDKDEEE EEEEEDDDLH1620
 1621 SSETTTLFKS QESLQANGGS HLAPNAAATS HTHTITLTNN NNHNSSNINN NIATSNTTTT1680
 1681 ANNNSMPVET

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..238] PSI-BLAST 5.30103 STRUCTURAL BASIS FOR THE AUTOINHIBITION AND STI-571 INHIBITION OF C-KIT TYROSINE KINASE
    2 View Details [239..347] deduced N/A No confident structure predictions are available.
    3 View Details [348..606] PSI-BLAST 54.0 Adenylyl cyclase VC1, domain C1a
    4 View Details [607..658] deduced N/A No confident structure predictions are available.
    5 View Details [659..1046] PSI-BLAST 6.69897 No description for 1y0fA was found.
    6 View Details [1047..1148] deduced N/A No confident structure predictions are available.
    7 View Details [1149..1360] deduced N/A No confident structure predictions are available.
    8 View Details [1361..1571] PSI-BLAST 71.09691 Type II adenylyl cyclase C2 domain
    9 View Details [1572..1690] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein kinase activity
    		•  2.49832339750991 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.40395553036038 bayes_pls_golite062009
  • kinase activity
    		•  2.19540905708538 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.99978484410702 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  1.41106972986741 bayes_pls_golite062009
  • binding
    		•  1.4090115174802 bayes_pls_golite062009
  • transferase activity
    		•  1.07753967998699 bayes_pls_golite062009
  • signal transducer activity
    		•  0.64449050025422 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.64449050025422 bayes_pls_golite062009
  • protein binding
    		•  0.507179243841744 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • signal transducer activity
    		•  1.69929193323663 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.69929193323663 bayes_pls_golite062009
  • cyclase activity
    		•  0.0777857375349 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8
    Term Confidence Notes
  • signal transducer activity
    		•  1.69929193323663 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.69929193323663 bayes_pls_golite062009
  • cyclase activity
    		•  0.0777857375349 bayes_pls_golite062009
    9 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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