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View Structure Prediction Details

Protein: Ac13E-PB, Ac13E-PA
Organism: Drosophila melanogaster
Length: 1690 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Ac13E-PB, Ac13E-PA.

Description E-value Query
Range		 Subject
Range
gi|2406633 - gi|2406633|gb|AAB70469.1| adenylyl cyclase isoform DAC9 [Drosophila melanogaster]
 1012.0 [0..1] [1651..1]

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Predicted Domain #1
Region A:
Residues: [1-238] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPPGVLVNDS RANSTDDIQI ALAPHIQTYL SQTGRRHSCC SVMLPVAFER AAAKSWLDPK  60
   61 FDSPVLEEQY QASVFPHVRM RYRFTLSYIL LCSLMWCLYF VVDGGSEDFW RPISSSFSML 120
  121 SLVTIMALCF THWDLYREHR TVTSAVTALL LCGASLAFLT YTGRAFSPLG HFAICLEIVL 180
  181 LIYTALPMPL WLGASTAISY SIAFEMVSHM VIGCSAIHGG PMHGGGGAAG GSGMEANG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.30103
Match: 1t45A
Description: STRUCTURAL BASIS FOR THE AUTOINHIBITION AND STI-571 INHIBITION OF C-KIT TYROSINE KINASE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein kinase activity 2.49832339750991 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 2.40395553036038 bayes_pls_golite062009
kinase activity 2.19540905708538 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.99978484410702 bayes_pls_golite062009
protein serine/threonine kinase activity 1.41106972986741 bayes_pls_golite062009
binding 1.4090115174802 bayes_pls_golite062009
transferase activity 1.07753967998699 bayes_pls_golite062009
signal transducer activity 0.64449050025422 bayes_pls_golite062009
molecular transducer activity 0.64449050025422 bayes_pls_golite062009
protein binding 0.507179243841744 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [239-347] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPSNRILILR IMAHLSVHLV GVHVLIMNLV RMRGTFMKVG QNLLVRRQLE MEKQLKEKMI  60
   61 HSVMPPKVAD MLLNEGGPSG LDAGGLPPES HYMRPRASND VKSLFRPFH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [348-606] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHSMENVSIL FADIVGFTRM SSTKTAEQLV EILNDLFERF DDLCSLSGCE KISTLGDCYY  60
   61 CVSGCPEPRA DHAICCVEMG LGMIDAMRCF DAQRHEGVKM RVGVHTGTVL CGIVGTRRVK 120
  121 FDVWSNDVSL ANKMESSGKP EQVHISQETS SFLGDAYYLE EGEEVFGHRT YFVVGRRRDF 180
  181 TRTNSLSPSM PANATGSSLL LPGAHGASLS QSATNVSAVQ PNVPPASPVG QLSSSLNPSP 240
  241 VLSMRPRLTS LSMKMRKKS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 54.0
Match: 1cjkA
Description: Adenylyl cyclase VC1, domain C1a
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
signal transducer activity 1.69929193323663 bayes_pls_golite062009
molecular transducer activity 1.69929193323663 bayes_pls_golite062009
cyclase activity 0.0777857375349 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [607-658] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QSRDRDVERG IIHPAAAGIP PVIVVRERPK IIITTKSLPG SLDSDEQPPV SP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [659-1046] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLLPPANPPA AETRSKIKLK VWKIPRFLKR FEDLTNRSSC GGSSSAGHLD KEREREREKE  60
   61 KEELHQHNQL NPEETLAFMD NQMQNGNGCG YQQLPVLVES NHRTQTLDIP AARPVLHHAA 120
  121 TSTALASSVL RSPEAGVSGG GGCCSPGQYS MYDDIIDVRS YISQSRSDIS PFGRSGSYRS 180
  181 QCGRQSTGGV NGAGPAGVGA EGRAGTSQTA PPVEQSPLPR PRASTLATGR PTPNSLEPGP 240
  241 SSTSPCCLPA PGNSVGGGGI FPPTHSRQSS ICPSATSRKD SGIKSNSRRS SIQQQIYALN 300
  301 QTAISQHRVS GYFTSSTSSI SNLGEVQGLG LPLAVQPPPP LLMPACSSQM ADPLAACLQQ 360
  361 LRKQSDLQLI RCVRDNARSQ RSYLVKPP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.69897
Match: 1y0fA
Description: No description for 1y0fA was found.

Predicted Domain #6
Region A:
Residues: [1047-1148] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LRKFSLYFKS RQLERDFRSK AHRFGAENET EGPPTLATPR YNTYIDIFVG IAVYLCISVS  60
   61 LFLMTQNTVS PSFRLWVTLF SCFTGIQVFA LFLFTRQMCR RQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [1149-1360] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGSNVSNRFR SKSTTSEDLE RDERGAAPGG RPHFESCADR IFEAISSWYP WHICLAVLMA  60
   61 MPVLLIIANF LLLDLEQLEA FEYHYGFLIF VCIVHFCNFT QLNCWVRNVL AFLAALCFIG 120
  121 IAVSQLMVYS HNRSDQQQDQ EASNFIQEIK WFQDYHVEIY LDLLLILVLV WFLNREFEIG 180
  181 YRLTFYGNAV ANQDKVRVQN MKNQADMLLH NI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [1361-1571] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPKHVAEHLK NTAKYSENHH NIAIIFASIV NFNEMYDESY LGGKEFLRVL NELIGDFDEL  60
   61 LSRPEFRAVE KIKTIGSTFM AASGLDPSHR GTGDEHIHTL MEFSIAMQEV VDAFNKDLLE 120
  121 FNLILRIGMN IGDVTAGVIG TSKLYYDIWG DAVNVASRMD STGLPNRIQV GKDCLPFLTN 180
  181 RYEFEPRGSV YVKGKDHMEV FLYTTRRDNP L

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 71.09691
Match: 1ab8A
Description: Type II adenylyl cyclase C2 domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
signal transducer activity 1.69929193323663 bayes_pls_golite062009
molecular transducer activity 1.69929193323663 bayes_pls_golite062009
cyclase activity 0.0777857375349 bayes_pls_golite062009

Predicted Domain #9
Region A:
Residues: [1572-1690] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDDEADKVEQ LGTKKMEHEG RDEDVVQGEQ QAEDKDEEEE EEEEDDDLHS SETTTLFKSQ  60
   61 ESLQANGGSH LAPNAAATSH THTITLTNNN NHNSSNINNN IATSNTTTTA NNNSMPVET

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle