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Protein Overview: mRNA-capping-enz...

General Information:
Name(s) found: mRNA-capping-enzyme-PA / FBpp0073739 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene mRNA-capping-enzyme is referred to in FlyBase by the symbol Dmel\mRNA-capping-enzyme (CG1810, FBgn0030556). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:14134299..14136852. It has the cytological map location 12E5. Based on sequence similarity, it is predicted to have molecular function</span>: mRNA guanylyltransferase activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: mRNA capping. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 649 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA]
    Biological Process: mRNA capping [ISS]
    protein amino acid dephosphorylation [IEA][NAS]
    Molecular Function: protein tyrosine phosphatase activity [IEA]
    mRNA guanylyltransferase activity [ISS]
    polynucleotide 5'-phosphatase activity [IEA]
    protein tyrosine/serine/threonine phosphatase activity [IEA][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALTNRDRER GSGPLPNRWL YCPRKSDTII AERFLAFKTP LSNNFHDKMP IECTFQPEML  60
   61 FEYCKTLKVK LGLWVDLTNT KRFYDRSAVE ELGAKYIKLQ CRGHGETPSP EQTHSFIEIV 120
  121 DNFINERPFD VIAVHCTHGF NRTGFLIVCY LVERLDCSVS AALAIFASAR PPGIYKQDYI 180
  181 NELYKRYEDT NAAPAAPEQP NWCLDYDDGN GDGFVQDNSS STSQQAGEQD DDAEEVEGED 240
  241 AGGDCDASTS DGQPRKKRRR EMIIKNATFM AGVPGVRQVS DQPRLGDLQR KVQDWCDWKK 300
  301 NGFPGAQPVS MDRENIKRLS EIPYRVSWKA DGTRYMMLID GRDEVYFFDR NHSCFQVENV 360
  361 TFVESRNLNE HLDGTLVDGE MVLDKIGETV TPRYLIYDIV RLSNRDVRDE PFYPNRLDYI 420
  421 KTEVIGPRIL GMKHGIINQR LQAFSVRGKD FWDIWMSARL LGEKFSRTLA HEPDGLIFQP 480
  481 SKQPYTAGTC SDVFKWKPHE LNSVDFRLKI ITERGEGLLT KKVGFLYVGG HDAPYGRMQR 540
  541 LTKETRELDN RIVECTMNQF GNWDFMRERT DKKNPNSYNT ARSVVDSIKH PVTKEYLLNF 600
  601 IASSGYRNDH VMMPPPINSH NQNHNHNHFY PHGHGQHQRR PCVNPTLGN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..215] PSI-BLAST 32.39794 CRYSTAL STRUCTURE OF THE HUMAN RNA guanylyltransferase and 5'- phosphatase
    2 View Details [216..448] FFAS03 4.14 No description for 2hivA was found.
    3 View Details [449..649] PSI-BLAST 37.154902 mRNA capping enzyme alpha subunit

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • nucleic acid binding
    		•  3.194200758646 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  3.08627215479695 bayes_pls_golite062009
  • DNA binding
    		•  2.71213098011194 bayes_pls_golite062009
  • binding
    		•  2.63617204791771 bayes_pls_golite062009
  • RNA binding
    		•  2.41160981373213 bayes_pls_golite062009
  • hydrolase activity
    		•  2.27001407788735 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.81524862921454 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.6315894906264 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  1.62996999055328 bayes_pls_golite062009
    		• 1.5765009871268 bayes_pls_golite062009
  • structural molecule activity
    		•  1.32534541097134 bayes_pls_golite062009
  • ribonuclease activity
    		•  1.19236946227657 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  1.15212468568198 bayes_pls_golite062009
  • exoribonuclease activity
    		•  1.10445667068538 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.996884322431837 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  0.83268201349295 bayes_pls_golite062009
  • translation regulator activity
    		•  0.613904794456162 bayes_pls_golite062009
  • nuclease activity
    		•  0.57381531077345 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.566068090112017 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  0.477127926059749 bayes_pls_golite062009
  • RNA polymerase activity
    		•  0.477127926059749 bayes_pls_golite062009
  • mRNA binding
    		•  0.4162128308402 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.32084431704638 bayes_pls_golite062009
  • translation initiation factor activity
    		•  0.30211828233765 bayes_pls_golite062009
  • transcription factor activity
    		•  0.298729064067577 bayes_pls_golite062009
  • protein binding
    		•  0.0528188351789111 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.00388708148970557 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle