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Protein Overview: PGRP-SA-PA, FBpp...

General Information:
Name(s) found: FBpp0309257 [FlyBase]
PGRP-SA-PA / FBpp0073358 [FlyBase]
Description(s) found:
Found 44 descriptions.
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  • type=protein; loc=X:join(11456006..11456313,11456372..11456490,11456552..11456736); ID=FBpp0309257; name=PGRP-SA-PB; parent=FBgn0030310,FBtr0340296; dbxref=FlyBase:FBpp0309257,FlyBase_Annotation_IDs:CG11709-PB; MD5=d5449799876422e9aa5ce14a97cbfbe2; length=203; release=r5.56; species=Dmel; [FlyBase]
  • The gene Peptidoglycan recognition protein SA is referred to in FlyBase by the symbol Dmel\PGRP-SA (CG11709, FBgn0030310). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:11455562..11456813. It has the cytological map location 10C6. There is experimental evidence that it has the molecular function</span>: protein binding; muramyl dipeptide binding; peptidoglycan binding. There is experimental evidence that it is involved in the biological process</span>: defense response to Gram-positive bacterium; positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria; response to peptidoglycan. 17 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 203 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [NAS]
    extracellular region [IDA][ISS]
    Biological Process: Toll signaling pathway [TAS]
    positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria [IMP][TAS]
    immune response [ISS][TAS]
    response to peptidoglycan [IMP]
    peptidoglycan catabolic process [IEA]
    innate immune response [NAS][TAS]
    regulation of Toll signaling pathway [TAS]
    detection of bacterium [NAS]
    defense response [NAS]
    defense response to Gram-positive bacterium [IGI][TAS]
    Molecular Function: peptidoglycan receptor activity [ISS][NAS][TAS]
    peptidoglycan binding [IDA][NAS][TAS]
    pattern recognition receptor activity [TAS]
    protein binding [IPI]
    N-acetylmuramoyl-L-alanine amidase activity [IEA]
    muramyl dipeptide binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQPVRFGSPW IMAIGLVLLL LAFVSAGKSR QRSPANCPTI KLKRQWGGKP SLGLHYQVRP  60
   61 IRYVVIHHTV TGECSGLLKC AEILQNMQAY HQNELDFNDI SYNFLIGNDG IVYEGTGWGL 120
  121 RGAHTYGYNA IGTGIAFIGN FVDKLPSDAA LQAAKDLLAC GVQQGELSED YALIAGSQVI 180
  181 STQSPGLTLY NEIQEWPHWL SNP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..203] PSI-BLAST 64.0 Crystal structure of the Drosophila pattern-recognition receptor PGRP-SA

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • peptidoglycan binding
    		•  9.32313496679335 bayes_pls_golite062009
  • peptidoglycan receptor activity
    		•  6.51660037886232 bayes_pls_golite062009
  • pattern recognition receptor activity
    		•  6.45255811818702 bayes_pls_golite062009
  • N-acetylmuramoyl-L-alanine amidase activity
    		•  5.29207604418857 bayes_pls_golite062009
  • receptor activity
    		•  4.17897828017337 bayes_pls_golite062009
  • pattern binding
    		•  4.06455798515101 bayes_pls_golite062009
  • signal transducer activity
    		•  3.23755187256204 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.23755187256204 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  3.20235326428146 bayes_pls_golite062009
  • muramyl dipeptide binding
    		•  2.98105613024406 bayes_pls_golite062009
  • binding
    		•  1.98584879067357 bayes_pls_golite062009
  • protein binding
    		•  1.3256655464253 bayes_pls_golite062009
  • hydrolase activity
    		•  1.14017500144843 bayes_pls_golite062009
    		• 0.808368163500401 bayes_pls_golite062009
  • catalytic activity
    		•  0.628556091191359 bayes_pls_golite062009
    		• 0.60706691535931 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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