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Protein Overview: Aats-lys-PA

General Information:
Name(s) found: Aats-lys-PA / FBpp0071301 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene Lysyl-tRNA synthetase is referred to in FlyBase by the symbol Dmel\Aats-lys (CG12141, FBgn0027084). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:9500393..9502917. It has the cytological map location 8F1. Based on sequence similarity, it is predicted to have molecular function</span>: lysine-tRNA ligase activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: lysyl-tRNA aminoacylation. 3 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 574 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEA]
    Biological Process: lysyl-tRNA aminoacylation [ISS][NAS]
    Molecular Function: nucleic acid binding [IEA]
    ATP binding [IEA]
    lysine-tRNA ligase activity [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAASGELSK NELKRRLKAE QKAKEKAEKA AAAPAENTAG KKKSSAAEEE EISPNEYFKL  60
   61 RSAAVQELKR SPATDPYPHK FHVSSSLEDF IAKYENSLKE GETLENVKLS VAGRVHAIRE 120
  121 SGAKLIFYDL RGEGVKVQVM ASAKSYKSEA DFEIDTSKLR RGDIIGVVGH PGKTKKGELS 180
  181 VMPSEIKLLS PCLHMLPHLH FGLKDKETRY RQRYLDLILN NNVREKFQIR AKIISYVRQF 240
  241 LDRLGFLEIE TPMMNMIAGG ATAKPFVTHH NDLKMDLFMR IAPELYHKML VVGGLDRVYE 300
  301 IGRQFRNEGI DLTHNPEFTT CEFYMAYADY ADIMDITEQL VSGMVKAIRG SYKVIYHPEG 360
  361 PEGPEQELDF TPPFKRVSMI KTLEEKLQVK FPAADTFNSP ETNQFLSQLC AKHQVECPAP 420
  421 RTTARLLDKL VGEFIEEFCV NPTFICEHPQ IMSPLAKYHR SIPGLTERFE LFVAKKEICN 480
  481 AYTELNDPVV QRERFEQQAS DKAAGDDEAQ LVDENFCTSL EYGLPPTGGF GMGIDRLAMF 540
  541 LTDSNNIKEV LLFPAMKPED ANRTAAETAP TAQQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..574] PSI-BLAST 148.0 Lysyl-tRNA synthetase (LysRS)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • lysine-tRNA ligase activity
    		•  11.0047124677093 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  7.89468709683036 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  7.89468709683036 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  7.88410036819636 bayes_pls_golite062009
  • ligase activity
    		•  6.92073480193262 bayes_pls_golite062009
  • aspartate-tRNA ligase activity
    		•  3.80084837437429 bayes_pls_golite062009
  • phenylalanine-tRNA ligase activity
    		•  3.4145644216516 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  2.90150581291897 bayes_pls_golite062009
  • glycine-tRNA ligase activity
    		•  2.61548498770105 bayes_pls_golite062009
  • structural molecule activity
    		•  2.54582212334303 bayes_pls_golite062009
  • proline-tRNA ligase activity
    		•  2.52223115725965 bayes_pls_golite062009
  • serine-tRNA ligase activity
    		•  2.46505535069103 bayes_pls_golite062009
  • threonine-tRNA ligase activity
    		•  2.18642354927 bayes_pls_golite062009
  • catalytic activity
    		•  1.99372273395202 bayes_pls_golite062009
  • alanine-tRNA ligase activity
    		•  1.82594054955281 bayes_pls_golite062009
  • histidine-tRNA ligase activity
    		•  1.72215103383322 bayes_pls_golite062009
  • translation initiation factor activity
    		•  1.27539679024898 bayes_pls_golite062009
  • asparagine-tRNA ligase activity
    		•  0.921492123574877 bayes_pls_golite062009
  • binding
    		•  0.916222310895772 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.56590887755068 bayes_pls_golite062009
  • ribonuclease activity
    		•  0.506819168662173 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.375542987753806 bayes_pls_golite062009
  • nuclease activity
    		•  0.29926900436997 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.281662799812287 bayes_pls_golite062009
  • DNA binding
    		•  0.0309732052586011 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle