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Protein Overview: Lim1-PA

General Information:
Name(s) found: Lim1-PA / FBpp0071216 [FlyBase]
Description(s) found:
Found 24 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\Lim1 (CG11354, FBgn0026411). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:8651268..8699808. It has the cytological map location 8A5-8B2. Based on sequence similarity, it is predicted to have molecular function</span>: transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: negative regulation of transcription; leg disc proximal/distal pattern formation; imaginal disc-derived leg morphogenesis; positive regulation of transcription. 25 alleles are reported. The phenotypes of these alleles are annotated with 16 unique terms, many of which group under: adult segment; appendage segment; organ system; antennal segment; thoracic segment; metatarsus; peripheral nervous system; nervous system; mouthpart; unguis; adult mesothoracic segment. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 505 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS]
    cellular_component [ND]
    Biological Process: biological_process [ND]
    imaginal disc-derived leg morphogenesis [IMP]
    negative regulation of transcription [IGI]
    regulation of transcription, DNA-dependent [IEA][ISS]
    positive regulation of transcription [IMP]
    regulation of transcription [IEA]
    leg disc proximal/distal pattern formation [IMP]
    Molecular Function: transcription factor activity [ISS]
    zinc ion binding [IEA]
    sequence-specific DNA binding [IEA]
    binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAFGAVLHTS QHNIGRSEPP VGVGDPCAGC NKPILDKFLL NVLERAWHAS CVRCCECLQP  60
   61 LTDKCFSRES KLYCRNDFFR RYGTKCSGCG QGIAPSDLVR KPRDKVFHLN CFTCCICRKQ 120
  121 LSTGEQLYVL DDNKFICKDD YLLGKAPSCG HNSLSDSLMG SASEDDDDDD PPHLRATALG 180
  181 LGVLGPNGPD SAGGPLGTSD ISVQSMSTDS KNTHDDSDQG SLDGDPDGRG DSQAENKSPD 240
  241 DANGSKRRGP RTTIKAKQLE VLKTAFNQTP KPTRHIREQL AKETGLPMRV IQVWFQNKRS 300
  301 KERRMKQITS MGRPPFFGGA RKMRGFPMNL SPGGLDDGPG FPYFAADAKF EFGYGGPFHP 360
  361 HDGPYFPGHP GGPMPFNAPG GPMDHSGPIP MVNEFGLTPE ATFLGQAGGP PMQLQSAVGP 420
  421 PPPPPPPSAE HLMAAAAAAA QQQAAQQQQQ QQQQQQQQQQ QNAQQAANQT QQQQQQNGPR 480
  481 TNSPEFMSSA NFSEPQNMQN EGLVW

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..151] PSI-BLAST 30.0 No description for 2dfyX was found.
    2 View Details [152..313] FFAS03 4.17 TERNARY COMPLEX OF THE DNA BINDING DOMAINS OF THE OCT1 AND SOX2 TRANSCRIPTION FACTORS WITH A 19MER OLIGONUCLEOTIDE FROM THE HOXB1 REGULATORY ELEMENT
    3 View Details [314..505] PSI-BLAST 3.69897 Sec24

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  4.86538715425734 bayes_pls_golite062009
  • DNA binding
    		•  4.40186699787632 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.28652307290136 bayes_pls_golite062009
  • transcription factor activity
    		•  3.78935192723648 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.25454589469681 bayes_pls_golite062009
  • transcription activator activity
    		•  2.92652250400688 bayes_pls_golite062009
  • binding
    		•  2.92574888336072 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.91588376840709 bayes_pls_golite062009
  • protein binding
    		•  1.84594855626241 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.69615348178304 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.57633910767639 bayes_pls_golite062009
  • chromatin binding
    		•  1.46954724788757 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.44773725829085 bayes_pls_golite062009
  • transcription factor binding
    		•  1.24678737091956 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.691780246385357 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.201150053959035 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.0723215858239072 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle