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Protein Overview: FBpp0309122, FBp...

General Information:
Name(s) found: FBpp0309123 [FlyBase]
FBpp0309122 [FlyBase]
mys-PA / FBpp0071061 [FlyBase]
Description(s) found:
Found 33 descriptions.
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  • type=protein; loc=X:join(7957991..7958492,7958566..7958794,7959481..7959565,7961095..7961529,7961593..7962816,7962903..7962968); ID=FBpp0309123; name=mys-PD; parent=FBgn0004657,FBtr0340137; dbxref=FlyBase:FBpp0309123,FlyBase_Annotation_IDs:CG1560-PD; MD5=a06e13616433a3bb31531504cda9d45c; length=846; release=r5.56; species=Dmel; [FlyBase]
  • type=protein; loc=X:join(7957991..7958492,7958566..7958794,7959481..7959565,7961095..7961529,7961593..7962816,7962903..7962968); ID=FBpp0309122; name=mys-PC; parent=FBgn0004657,FBtr0340136; dbxref=FlyBase:FBpp0309122,FlyBase_Annotation_IDs:CG1560-PC; MD5=a06e13616433a3bb31531504cda9d45c; length=846; release=r5.56; species=Dmel; [FlyBase]
  • The gene myospheroid is referred to in FlyBase by the symbol Dmel\mys (CG1560, FBgn0004657). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:7955680..7964270. It has the cytological map location 7D5. It is reported to have molecular function</span>: cell adhesion molecule binding; receptor activity. There is experimental evidence that it is involved in the biological process</span>: regulation of cell shape; central nervous system development; determination of adult lifespan; axon guidance; hemocyte migration; cell adhesion; muscle organ development; maintenance of epithelial integrity, open tracheal system; substrate-bound cell migration, cell extension. 140 alleles are reported. The phenotypes of these alleles are annotated with 53 unique terms, many of which group under: organ system; hypodermal muscle of larval abdomen; adult segment; nervous system; primordium; larval abdominal segment 5; external compound sense organ; adult mesothoracic segment; larval abdominal segment; extended germ band embryo. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 846 amino acids

    Gene Ontology:
    Cellular Component: focal adhesion [ISS]
    cell leading edge [IDA]
    integrin complex [IEA][ISS][NAS]
    Biological Process: dorsal closure [TAS]
    cell-matrix adhesion [IEA][TAS]
    regulation of cell shape [IMP]
    hemocyte migration [IGI]
    calcium-dependent cell-cell adhesion [TAS]
    midgut development [TAS]
    determination of adult lifespan [IMP]
    heterophilic cell-cell adhesion [TAS]
    axon guidance [IMP]
    cell adhesion [IMP]
    apposition of dorsal and ventral imaginal disc-derived wing surfaces [NAS]
    maintenance of epithelial integrity, open tracheal system [IMP]
    substrate-bound cell migration, cell extension [IGI]
    tracheal outgrowth, open tracheal system [TAS]
    muscle organ development [IMP]
    epithelial cell migration, open tracheal system [TAS]
    integrin-mediated signaling pathway [IEA]
    central nervous system development [IMP]
    calcium-dependent cell-matrix adhesion [ISS]
    cell migration [TAS]
    muscle attachment [TAS]
    Molecular Function: cell adhesion molecule binding [TAS]
    receptor activity [IEA][TAS]
    binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MILERNRRCQ LALLMIAILA AIAGQTDAQK AAKLTAVSTC ASKEKCHTCI QTEGCAWCMQ  60
   61 PDFKGQSRCY QNTSSLCPEE FAYSPITVEQ ILVNNKLTNQ YKAELAAGGG GSAMSGSSSS 120
  121 SYSSSSSSSS FYSQSSSGSS SASGYEEYSA GEIVQIQPQS MRLALRVNEK HNIKISYSQA 180
  181 EGYPVDLYYL MDLSKSMEDD KAKLSTLGDK LSETMKRITN NFHLGFGSFV DKVLMPYVST 240
  241 IPKKLEHPCE NCKAPYGYQN HMPLNNNTES FSNEVKNATV SGNLDAPEGG FDAIMQAIAC 300
  301 RSQIGWREQA RRLLVFSTDA GFHYAGDGKL GGVIAPNDGE CHLSPKGEYT HSTLQDYPSI 360
  361 SQINQKVKDN AINIIFAVTA SQLSVYEKLV EHIQGSSAAK LDNDSSNVVE LVKEEYRKIS 420
  421 SSVEMKDNAT GDVKITYFSS CLSNGPEVQT SKCDNLKEGQ QVSFTAQIQL LKCPEDPRDW 480
  481 TQTIHISPVG INEVMQIQLT MLCSCPCENP GSIGYQVQAN SCSGHGTSMC GICNCDDSYF 540
  541 GNKCECSATD LTSKFANDTS CRADSTSTTD CSGRGHCVCG ACECHKRPNP IEIISGKHCE 600
  601 CDNFSCERNR NQLCSGPDHG TCECGRCKCK PGWTGSNCGC QESNDTCMPP GGGEICSGHG 660
  661 TCECGVCKCT VNDQGRFSGR HCEKCPTCSG RCQELKDCVQ CQMYKTGELK NGDDCARNCT 720
  721 QFVPVGVEKV EIDETKDEQM CKFFDEDDCK FMFKYSEQGE LHVYAQENKE CPAKVFMLGI 780
  781 VMGVIAAIVL VGLAILLLWK LLTTIHDRRE FARFEKERMN AKWDTGENPI YKQATSTFKN 840
  841 PMYAGK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..774] PSI-BLAST 159.0 Hybrid domain of integrin beta; Integrin beta A domain; Integrin beta tail domain; Integrin beta EGF-like domains
    2 View Details [775..846] FFAS03 3.85 NMR Structure of the integrin B3 cytoplasmic domain in DPC micelles


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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