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Protein Overview: ovo-PE, ovo-PB

General Information:
Name(s) found: ovo-PE / FBpp0291128 [FlyBase]
ovo-PB / FBpp0070706 [FlyBase]
Description(s) found:
Found 30 descriptions.
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  • The gene ovo is referred to in FlyBase by the symbol Dmel\ovo (CG6824, FBgn0003028). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:4942330..4964962. It has the cytological map location 4E2. There is experimental evidence that it has the molecular function</span>: sequence-specific DNA binding; transcription repressor activity; transcription activator activity; DNA binding. There is experimental evidence that it is involved in the biological process</span>: pheromone metabolic process; cuticle pigmentation; non-sensory hair organization; positive regulation of transcription from RNA polymerase II promoter; cuticle pattern formation; germ-line sex determination; negative regulation of transcription from RNA polymerase II promoter; adult feeding behavior; epidermal cell differentiation. 186 alleles are reported. The phenotypes of these alleles are annotated with 28 unique terms, many of which group under: organ system; female germline cyst; adult segment; cuticle; peripheral nervous system; external compound sense organ; egg; antennal segment; nervous system; cell part. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
  • The gene ovo is referred to in FlyBase by the symbol Dmel\ovo (CG6824, FBgn0003028). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:4942330..4964962. It has the cytological map location 4E2. There is experimental evidence that it has the molecular function</span>: sequence-specific DNA binding; transcription repressor activity; transcription activator activity; DNA binding. There is experimental evidence that it is involved in the biological process</span>: pheromone metabolic process; cuticle pigmentation; non-sensory hair organization; positive regulation of transcription from RNA polymerase II promoter; cuticle pattern formation; germ-line sex determination; negative regulation of transcription from RNA polymerase II promoter; adult feeding behavior; epidermal cell differentiation. 186 alleles are reported. The phenotypes of these alleles are annotated with 28 unique terms, many of which group under: organ system; female germline cyst; adult segment; cuticle; peripheral nervous system; external compound sense organ; egg; antennal segment; nervous system; cell part. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1351 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IC][ISS][NAS]
    Biological Process: adult feeding behavior [IMP]
    positive regulation of transcription from RNA polymerase II promoter [IMP]
    regulation of transcription [TAS]
    cuticle development [TAS]
    pheromone metabolic process [IMP]
    negative regulation of transcription from RNA polymerase II promoter [IMP]
    cuticle pigmentation [IMP]
    epidermal cell differentiation [IMP]
    oogenesis [TAS]
    female germ-line sex determination [NAS]
    germ-line sex determination [IGI][IMP]
    non-sensory hair organization [IMP][TAS]
    cuticle pattern formation [IMP]
    Molecular Function: DNA binding [IDA][TAS]
    zinc ion binding [IEA]
    RNA polymerase II transcription factor activity [ISS]
    sequence-specific DNA binding [IDA]
    transcription activator activity [IMP]
    transcription repressor activity [IMP]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPKIFLIKNR LHQQQQRLLE SQNLLQHKNQ DDERLVPPLS PSGSGSGPSP TPTSQPPPEP  60
   61 QGQGQQVLGQ VPDSDQQPLS LTRKRFHHRR HYFGQSRHSL DHLNQNQSPN PNANANPNQI 120
  121 QNPAELEVEC ATGQVQNENF AAELLQRLTP NTATTAQNNI VNNLVNNSRA ATSVLATKDC 180
  181 TIENSPISIP KNQRAEDEEE QEDQEKEKPA EREREKSDER TEQVEKEERV EREEEEDDEV 240
  241 DVGVEAPRPR FYNTGVVLTQ AQRKEYPQEP KDLSLTIAKS SPASPHIHSD SESDSDSDGG 300
  301 CKLIVDEKPP LPVIKPLSLR LRSTPPPADQ RPSPPPPRDP APAVRCSVIQ RAPQSQLPTS 360
  361 RAGFLLPPLD QLGPEQQEPI DYHVPKRRSP SYDSDEELNA RRLERARQVR EARRRSTILA 420
  421 ARVLLAQSQR LNPRLVRSLP GILAAAAGHG RNSSSSSGAA GQGFQSSGFG SQNSGSGSSS 480
  481 GNQNAGSGAG SPGSGAGGGG GMGGGRDGRG NYGPNSPPTG ALPPFYESLK SGQQSTASNN 540
  541 TGQSPGANHS HFNANPANFL QNAAAAAYIM SAGSGGGGCT GNGGGGASGP GGGPSANSGG 600
  601 GGGGGGGNGY INCGGVGGPN NSLDGNNLLN FASVSNYNES NSKFHNHHHH HQHNNNNNNN 660
  661 GGQTSMMGHP FYGGNPSAYG IILKDEPDIE YDEAKIDIGT FAQNIIQATM GSSGQFNASA 720
  721 YEDAIMSDLA SSGQCPNGAV DPLQFTATLM LSSQTDHLLE QLSDAVDLSS FLQRSCVDDE 780
  781 ESTSPRQDFE LVSTPSLTPD SVTPVEQHNT NTTQLDVLHE NLLTQLTHNI VRGGSNQQQQ 840
  841 HHQQHGVQQQ QQQQHSVQQQ QQHNVQQQHG VQQQHVQQQP PPSYQHATRG LMMQQQPQHG 900
  901 GYQQQAAIMS QQQQQLLSQQ QQQSHHQQQQ QQQHAAAYQQ HNIYAQQQQQ QQQQHHQQQQ 960
  961 QQQHHHFHHQ QQQQPQPQSH HSHHHGHGHD NSNMSLPSPT AAAAAAAAAA AAAAAAAAHL1020
 1021 QRPMSSSSSS GGTNSSNSSG GSSNSPLLDA NAAAAAAAAL LDTKPLIQSL GLPPDLQLEF1080
 1081 VNGGHGIKNP LAVENAHGGH HRIRNIDCID DLSKHGHHSQ HQQQQGSPQQ QNMQQSVQQQ1140
 1141 SVQQQQSLQQ QQQQQHHQHH SNSSASSNAS SHGSAEALCM GSSGGANEDS SSGNNKFVCR1200
 1201 VCMKTFSLQR LLNRHMKCHS DIKRYLCTFC GKGFNDTFDL KRHTRTHTGV RPYKCNLCEK1260
 1261 SFTQRCSLES HCQKVHSVQH QYAYKERRAK MYVCEECGHT TCEPEVHYLH LKNNHPFSPA1320
 1321 LLKFYDKRHF KFTNSQFANN LLGQLPMPVH N

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..61] deduced N/A No confident structure predictions are available.
    2 View Details [62..283] deduced N/A No confident structure predictions are available.
    3 View Details [284..362] deduced N/A No confident structure predictions are available.
    4 View Details [363..734] PSI-BLAST 43.30103 No description for 1y0fA was found.
    5 View Details [735..814] deduced N/A No confident structure predictions are available.
    6 View Details [815..1025] MSA 1.513997 View MSA. No confident structure predictions are available.
    7 View Details [1026..1157] deduced N/A No confident structure predictions are available.
    8 View Details [1158..1351] PSI-BLAST 67.69897 No description for 2i13A was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.52

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle