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Protein Overview: l(1)G0334-PC

General Information:
Name(s) found: l(1)G0334-PC / FBpp0070679 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene lethal (1) G0334 is referred to in FlyBase by the symbol Dmel\l(1)G0334 (CG7010, FBgn0028325). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:4596305..4599156. It has the cytological map location 4C14. Based on sequence similarity, it is predicted to have molecular function</span>: pyruvate dehydrogenase (acetyl-transferring) activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: pyruvate metabolic process. 5 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 443 amino acids

    Gene Ontology:
    Cellular Component: pyruvate dehydrogenase complex [ISS]
    intracellular membrane-bounded organelle [IEA]
    Biological Process: glycolysis [IEA]
    oxidation reduction [IEA]
    pyruvate metabolic process [ISS]
    Molecular Function: pyruvate dehydrogenase (acetyl-transferring) activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRTLSRVSE LPIIVKQLQK RCHNNNNNNI IISGCRILSN NNNNSSIDII RNGRYSSSFF  60
   61 GLFQNAAQAG VSKTNNYATE ATVQVNRPFK LHRLDEGPAT EVKLTKDQAL KYYTQMQTIR 120
  121 RLETAAGNLY KEKIIRGFCH LYSGQEACAV GMKAAMRDVD NIISAYRVHG WTYLMGVSPS 180
  181 GVLAELTGVQ GGCARGKGGS MHMYAPNFYG GNGIVGAQVP LGAGVGLACK YKGNGGMCLA 240
  241 LYGDGAANQG QVFEAYNMAY LWKLPVIFVC ENNNYGMGTS SERASCNTDY YTRGDALPGI 300
  301 WVDGMDVLAV RSATEFAINY VNTHGPLVME TNTYRYSGHS MSDPGTSYRT REEIQEVRQK 360
  361 RDPITSFKEL CIELGLITTD EVKAIDLKVR KEVDEATAFA KSDAELGVSH LWTDVYSNNL 420
  421 EPKLRGTIAY DIDHIQERKG VNH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..443] PSI-BLAST 93.30103 E1-beta subunit of pyruvate dehydrogenase (PP module)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • pyruvate dehydrogenase activity
    		•  11.3856674722026 bayes_pls_golite062009
  • pyruvate dehydrogenase (acetyl-transferring) activity
    		•  11.0549577473177 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
    		•  10.8180381281695 bayes_pls_golite062009
  • 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity
    		•  7.00951713446616 bayes_pls_golite062009
  • alpha-ketoacid dehydrogenase activity
    		•  6.25236550086321 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  4.89064211833637 bayes_pls_golite062009
  • acetolactate synthase activity
    		•  4.51986503762195 bayes_pls_golite062009
  • transferase activity, transferring aldehyde or ketonic groups
    		•  3.8269109174531 bayes_pls_golite062009
  • 2-oxoisovalerate dehydrogenase (acylating) activity
    		•  3.00128844859152 bayes_pls_golite062009
  • cyclin-dependent protein kinase 5 activator regulator activity
    		•  3.00128844859152 bayes_pls_golite062009
  • catalytic activity
    		•  2.25537597692103 bayes_pls_golite062009
  • oxidoreductase activity
    		•  1.85833680148029 bayes_pls_golite062009
  • transketolase activity
    		•  1.53492491341322 bayes_pls_golite062009
  • protein binding
    		•  0.992849906276347 bayes_pls_golite062009
  • binding
    		•  0.750068469698571 bayes_pls_golite062009
  • transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
    		•  0.667418924427388 bayes_pls_golite062009
  • pyruvate decarboxylase activity
    		•  0.198062360371269 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle