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Protein Overview: pon-PA

General Information:
Name(s) found: pon-PA / FBpp0070649 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene partner of numb is referred to in FlyBase by the symbol Dmel\pon (CG3346, FBgn0025739). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:4530363..4533145. It has the cytological map location 4C10. Its molecular function is unknown. It is reported to be involved in the biological process</span>: asymmetric neuroblast division; asymmetric protein localization. 18 alleles are reported. The phenotypes of these alleles are annotated with: abdominal 6 lateral transverse muscle 3; abdominal 2 lateral transverse muscle 3; abdominal 4 lateral transverse muscle 3; embryonic/larval pericardial cell; abdominal 5 lateral transverse muscle 3; abdominal 3 lateral transverse muscle 3; abdominal 7 lateral transverse muscle 3; embryonic/larval somatic muscle. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 670 amino acids

    Gene Ontology:
    Cellular Component: basal part of cell [TAS]
    cytoplasm [IDA]
    cell cortex [IDA]
    basal cortex [NAS]
    Biological Process: asymmetric neuroblast division [TAS]
    asymmetric protein localization [TAS]
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLETKSIAAL AFTETPRKRK RETLYKNAAP PPNPQQQPPE KDAQDAAVAS TESCFTNAAF  60
   61 SSTPKKLMVA RRRLAKENSQ PNPFPGLEVK SIADLAQKQQ HQQHHQQQQQ QQQKLPTNPF 120
  121 EVLRQPPKKK KREHACFENP GLNLELPEKQ FNPYEVVRSA TTPAKGFVNP ALNLRGSDAP 180
  181 ASLNPFEIHR PSEASEAACN PSGVANPALA DRDSEEQLPT SLKIGLPFTP TLGCRIDFHG 240
  241 MSLTQLTPSK LLAEKLVFSP VPAPKRSLGA ISEESSMDIG KELDRYQLEL ENSINEAKLR 300
  301 KNGVLVDREL PRNSLEVELP KNTKVSLVME TNTQELMMQE VVTVDTQVER RLVCTRRRTL 360
  361 TEISEASEVE EDTEKLLEQD REAEVILEQE KILEQEMVSE RERHLTREKQ LKQEKLLERE 420
  421 KHLEREKLQE KLHEQLREKL QERAKHLEKE KLEEEELLER QLEEEREKEP TDGDVAYASE 480
  481 SESDDEPDDL DFKAPARFVR AYRPAALPSK AASKESLQSI GSSKSAKSAE VKPSIGMKGM 540
  541 IRKSIRRLMH PTSHTTPSEV KSEDKDEHGH GQGHGQHNIL NSIRHSLRRR PQKAAELEEQ 600
  601 MEPVLADVSI IDTSERTMKL RSSVAQTEYM TIEQLTNEKK HSLRNSIRRS TRDVLRHVFH 660
  661 KSHDAYATAK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..189] deduced N/A No confident structure predictions are available.
    2 View Details [190..350] PSI-BLAST 5.09691 No description for 2h94A was found.
    3 View Details [351..670] PSI-BLAST 17.30103 Heavy meromyosin subfragment

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  1.95113868888523 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.67817541368103 bayes_pls_golite062009
  • DNA binding
    		•  1.65628621585174 bayes_pls_golite062009
  • transcription factor activity
    		•  1.2199858816759 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.06610635349341 bayes_pls_golite062009
  • protein binding
    		•  0.853351196918381 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.79002371725751 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.492703104512863 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.42857545583097 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0621386040786331 bayes_pls_golite062009
  • actin binding
    		•  0.0317334287062701 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle