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Protein Overview: dnc-PF

General Information:
Name(s) found: dnc-PF / FBpp0070497 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene dunce is referred to in FlyBase by the symbol Dmel\dnc (CG32498, FBgn0000479). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:3070475..3233360. It has the cytological map location 3C9-3D1. Based on sequence similarity, it is predicted to have molecular function</span>: 3',5'-cyclic-AMP phosphodiesterase activity. There is experimental evidence that it is involved in the biological process</span>: synaptic transmission; conditioned taste aversion; short-term memory; axon extension. 72 alleles are reported. The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: anatomical structure; organ system; embryonic neuron; embryonic nervous system; female germline cyst; nervous system; developing anatomical structure; egg; multi-cell-component structure; synapse; postsynaptic membrane; adult brain; neuromuscular junction. It has 12 annotated transcripts and 12 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 662 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: nonassociative learning [TAS]
    signal transduction [IEA]
    cyclic nucleotide metabolic process [NAS]
    synaptic transmission [IMP]
    olfactory learning [TAS]
    behavioral response to ethanol [NAS]
    learning [NAS]
    circadian rhythm [TAS]
    associative learning [TAS]
    memory [TAS]
    behavior [TAS]
    reproduction [NAS]
    conditioned taste aversion [IMP]
    learning or memory [NAS][TAS]
    mating behavior [TAS]
    short-term memory [IMP]
    oogenesis [TAS]
    locomotor rhythm [NAS]
    axon extension [IMP]
    courtship behavior [TAS]
    cAMP-mediated signaling [NAS]
    Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity [ISS][TAS]
    3',5'-cyclic-nucleotide phosphodiesterase activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLNKNSASSQ SLPRVHSFFN MIPSIMQDDL ALTILNDRDN MFSIKSQRSH GEDLIVTPFA  60
   61 QILASLRSVR NNLLSLTNVP ASNKSRRPNQ SSSASRSGNP PGAPLSQGEE AYTRLATDTI 120
  121 EELDWCLDQL ETIQTHRSVS DMASLKFKRM LNKELSHFSE SSRSGNQISE YICSTFLDKQ 180
  181 QEFDLPSLRV EDNPELVAAN AAAGQQSAGQ YARSRSPRGP PMSQISGVKR PLSHTNSFTG 240
  241 ERLPTFGVET PRENELGTLL GELDTWGIQI FSIGEFSVNR PLTCVAYTIF QSRELLTSLM 300
  301 IPPKTFLNFM STLEDHYVKD NPFHNSLHAA DVTQSTNVLL NTPALEGVFT PLEVGGALFA 360
  361 ACIHDVDHPG LTNQFLVNSS SELALMYNDE SVLENHHLAV AFKLLQNQGC DIFCNMQKKQ 420
  421 RQTLRKMVID IVLSTDMSKH MSLLADLKTM VETKKVAGSG VLLLDNYTDR IQVLENLVHC 480
  481 ADLSNPTKPL PLYKRWVALL MEEFFLQGDK ERESGMDISP MCDRHNATIE KSQVGFIDYI 540
  541 VHPLWETWAD LVHPDAQDIL DTLEENRDYY QSMIPPSPPP SGVDENPQED RIRFQVTLEE 600
  601 SDQENLAELE EGDESGGEST TTGTTGTTAA SALSGAGGGG GGGGGMAPRT GGCQNQPQHG 660
  661 GM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..84] MSA 3.05198 View MSA. No confident structure predictions are available.
    2 View Details [85..229] MSA 6.172995 View MSA. No confident structure predictions are available.
    3 View Details [230..662] PSI-BLAST 130.0 No description for 2fm0A was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.86

    Source: Reynolds et al. (2008)

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    Created and Maintained by: Michael Riffle