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Protein Overview: CG10260-PB

General Information:
Name(s) found: CG10260-PB / FBpp0070427 [FlyBase]
Description(s) found:
Found 12 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG10260 (CG10260, FBgn0040335). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:2519051..2527386. It has the cytological map location 3A8. Based on sequence similarity, it is predicted to have molecular function</span>: 1-phosphatidylinositol 4-kinase activity. It is reported to be involved in the biological process</span>: phosphorylation. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 2178 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: phosphoinositide-mediated signaling [IEA]
    phosphoinositide phosphorylation [IEA]
    phosphorylation [NAS]
    Molecular Function: 1-phosphatidylinositol 4-kinase activity [ISS][NAS]
    binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTMTASDKYT YQRTVLCLAR VLAGIQPTPW DKVHVHLATH STSHSASPPG NRLFALTLSG  60
   61 GHKTDMRGRS GGGGKAVQTL FRYCPQENAA GVFCLDTRAQ DAVIALGIYF LEGGCQHEGQ 120
  121 IVPYLLRLAK CLPKAVWIDD ARSNKVERVR IPSAEKFSFC LNTLLSDIAA KCPDSREEII 180
  181 LNQVETLSAL ANIVKSSRDS SSAPPPIILC KATVPLLFGL ARSMGRYASN DPPLLCRIFP 240
  241 PELLPIQKGG GRDGTGSSSS ASGTCGGSFS SSERLAATHH FRPIIPRSMS GSLAQAQNAS 300
  301 YDDGRQRCAG GKPSKPSLHS YFSVPYDPRT HFFTRYGSSF NQFPNMRVCE SPTKGGPRPL 360
  361 YRVPPFPIQH LQTIFAVSKK LLTKDTLEHL DEQASDIFSL HQIKGYCYKS FSETLNLVLV 420
  421 TLLRELLQHQ VDLPTPFTKD VQEFVKRLFL NGQTELQNKQ QDQERERREE NGIAVVNKYK 480
  481 VNVMANAACV DLLVWAIRDE TEADKLCGRL SQKLNLELSH KIVMDHMPLL MVCLEGLGKL 540
  541 AHKFPNIAGT SISYLRDFLV APSPILGKLH DHAMQSLAQQ KKEKELTPFK IAVQHSDSRT 600
  601 AVVIYGDNQK PPGSGTGRSG HAAFESLRDA AIENLSIALR AAHTLDQFCV PALVANVSNR 660
  661 LFTAEKSGSE SQGECHKSNL VSLNIIVMLG HVAVALKDTS KTTQNILQFF IQRFCKVPSE 720
  721 QNALIVDQLG CMIISQCETH VFDEIMKMFS RVTVQSASLA YTSDPEHRKQ FHHVSDAVVN 780
  781 ALGNIAANIQ GDAEMLELLG KLLELFVQIG LDGERSYDNT PGAQKASSRA GNLGMLIPVI 840
  841 AVLVRRLPPI KNPRQRLHKL FKDFWAYCVV MGFTNARLWP ADWYQGVQQI AAKSPLLISQ 900
  901 TAHKSDMREL NYTLAIKSDS VNELRSQILV LLEHSSDNVA TAINKLSFAQ CTYLLSVYWL 960
  961 EMLRVENADE PSLEPIMSYL CDTALQRDKT GIWQCVKCVA DQVFEKFRNV LYAHDEIREK1020
 1021 VLESQATLLL VYFNHIHKPI QMVADQYLSF LVDRFPHLLW NRRVLWCMLD ILQLLAYSLS1080
 1081 LDPNEETPTL RVVSTPYTLQ LMDSLPAREL RLKDFADRCQ GIVNEAMKWA PRSTRSHLQE1140
 1141 YPNQIPTPVL AHHSGLALAF DSVVSSSAQH TGTMSKRPSC VNSDTPRFVS VLCLRSKYAG1200
 1201 EISGLLSVLS EKDKAGLADR LVSDVWEACA EKSDARHRGA LWRATAYLII CSEISRKLLH1260
 1261 AVASSQLELF TESAMETAVE CWQWVLTARQ DLELCFIQEM VSAWQTTFEK RMGLFAWETE1320
 1321 VTHPLAAYEG CKLVSKPILI APHLIWLQLL SEMVDTAKYC NRDKVEMFCL LLHRCLPVLK1380
 1381 SSKQNRQVST VGCRFKLLQC GLSLLQGNTI PKSLSRNILR ERIYSNALDY FCGPPTCPNQ1440
 1441 SREQLLEDIM ILLKFWQTMR SEKKHLVTSE VGDYDLTNAS VSSTQMLAVR NNPETASLIS1500
 1501 GGGLVNDYTR SMSASGNAVG MGMGVAGGGS SSGWYNTIPH STSTLSKRSN RSKRLQYQKD1560
 1561 SYDKDYMKKR NLILELLAVE LEFLITWYNP NSLPDLIVPG EEQITEWRNR PYKSTVWRDY1620
 1621 ARLAWCYNPA LAVFLPQRIK NAEIIDEEVS RLVCSDPIAV CHIPEALKYL CTTKNLLQES1680
 1681 PDLVYILSWS PVTPIQALAY FSRQYPSHPL TAQYAVKTLS SYPAESVLPY IPQLVQALRH1740
 1741 DTMGYVVEFI KNISRRSQIV AHQLIWNMQT NMYMDEDQQH KDPNLYEALD QLSQSIIASF1800
 1801 SGAAKRFYER EFDFFGKITA VSGEIRSFAK GIERKNACLA ALSRIKVQGG CYLPSNPEAM1860
 1861 VLDIDYSSGT PMQSAAKAPY LARFRVYRCG ITELETRAME VSNNPNSQED AKMTLGVESW1920
 1921 QAAIFKVGDD VRQDMLALQV ITIFKNIFQQ VGLDLFLFPY RVVATAPGCG VIECVPNAKS1980
 1981 RDQLGRQTDS GLSEYFQHQY GDESSKEFQA ARANFVKSMA AYSLIGYLLQ IKDRHNGNIM2040
 2041 IDKDGHIIHI DFGFMFESSP GGNIGFEPDM KLTDEMVMIM GGKMDSPAFK WFCELCVQAF2100
 2101 LAVRPYQDAI VSLVSLMLDT GLPCFRGQTI NLLKQRFVAT KNNKEAAAHM LAVIRNSYQN2160
 2161 FRTRTYDMIQ YYQNQIPY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..84] deduced N/A No confident structure predictions are available.
    2 View Details [85..255] deduced N/A No confident structure predictions are available.
    3 View Details [256..342] deduced N/A No confident structure predictions are available.
    4 View Details [343..431] deduced N/A No confident structure predictions are available.
    5 View Details [432..502] MSA 1.029986 View MSA. No confident structure predictions are available.
    6 View Details [503..820] deduced N/A No confident structure predictions are available.
    7 View Details [821..897] deduced N/A No confident structure predictions are available.
    8 View Details [898..987] deduced N/A No confident structure predictions are available.
    9 View Details [988..1163] deduced N/A No confident structure predictions are available.
    10 View Details [1164..1431] deduced N/A No confident structure predictions are available.
    11 View Details [1432..2178] PSI-BLAST 125.0 Phoshoinositide 3-kinase (PI3K) helical domain; Phoshoinositide 3-kinase (PI3K); Phoshoinositide 3-kinase (PI3K), catalytic domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.
    11
    Term Confidence Notes
  • protein kinase activity
    		•  4.39461982655248 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  4.32184067232044 bayes_pls_golite062009
  • kinase activity
    		•  4.16135267871365 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  3.92556971928915 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  3.76541923765309 bayes_pls_golite062009
  • transferase activity
    		•  2.57136779276375 bayes_pls_golite062009
  • binding
    		•  2.31930216202447 bayes_pls_golite062009
  • calcium-dependent phospholipid binding
    		•  2.27288137663828 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.0371109148587 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.95775692939268 bayes_pls_golite062009
  • signal transducer activity
    		•  1.95775692939268 bayes_pls_golite062009
  • ATP binding
    		•  1.62950013799854 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.59120412984243 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.57251948653832 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.32931505255952 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.32676572752438 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.31489723493061 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.3145826655017 bayes_pls_golite062009
  • nucleotide binding
    		•  1.31339663939554 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.27941426224024 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  1.27740808551012 bayes_pls_golite062009
  • protein binding
    		•  1.22565748038754 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • receptor activity
    		•  1.13726344123824 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.05231366895645 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.96468055729151 bayes_pls_golite062009
  • syntaxin binding
    		•  0.909935562401489 bayes_pls_golite062009
  • phospholipid binding
    		•  0.847352576231533 bayes_pls_golite062009
  • lipid kinase activity
    		•  0.74363752721495 bayes_pls_golite062009
  • phosphoinositide 3-kinase activity
    		•  0.62974411024989 bayes_pls_golite062009
  • 1-phosphatidylinositol-3-kinase activity
    		•  0.5042126149163 bayes_pls_golite062009
  • inositol or phosphatidylinositol kinase activity
    		•  0.328918574945998 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.134745748018448 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.80

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle