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Protein Overview: usp-PA, FBpp0305937

General Information:
Name(s) found: FBpp0305937 [FlyBase]
usp-PA / FBpp0070332 [FlyBase]
Description(s) found:
Found 35 descriptions.
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  • type=protein; loc=X:complement(1933420..1934946); ID=FBpp0305937; name=usp-PB; parent=FBgn0003964,FBtr0333803; dbxref=REFSEQ:NP_001259168,GB_protein:AGB95014,FlyBase:FBpp0305937,FlyBase_Annotation_IDs:CG4380-PB; MD5=c17ce772530806ea2bde889f24a9595d; length=508; release=r5.56; species=Dmel; [FlyBase]
  • The gene ultraspiracle is referred to in FlyBase by the symbol Dmel\usp (CG4380, FBgn0003964). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:1932829..1935316. It has the cytological map location 2C7. There is experimental evidence that it has the molecular function</span>: ecdysteroid hormone receptor activity; protein binding; lipid binding; protein heterodimerization activity; protein homodimerization activity. There is experimental evidence that it is involved in the biological process</span>: border follicle cell migration; dendrite morphogenesis; neuron development; neuron remodeling; muscle organ development. 22 alleles are reported. The phenotypes of these alleles are annotated with: terminal filament; embryonic/larval anterior spiracle; midgut imaginal island; imaginal disc. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 508 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][ISS][NAS]
    polytene chromosome [NAS]
    dendrite [IMP]
    ecdysone receptor holocomplex [TAS]
    Biological Process: muscle organ development [IMP]
    negative regulation of transcription, DNA-dependent [TAS]
    regulation of development, heterochronic [TAS]
    negative regulation of cell differentiation [TAS]
    positive regulation of transcription [TAS]
    regulation of transcription, DNA-dependent [IEA]
    border follicle cell migration [IMP]
    metamorphosis [NAS]
    ecdysone-mediated induction of salivary gland cell autophagic cell death [NAS]
    neuron development [IMP]
    neuron remodeling [IMP]
    dendrite morphogenesis [IMP][NAS]
    Molecular Function: DNA binding [NAS]
    transcription factor activity [ISS]
    zinc ion binding [IEA]
    protein binding [IPI]
    protein homodimerization activity [IDA]
    ligand-dependent nuclear receptor activity [ISS][NAS]
    protein heterodimerization activity [IDA]
    lipid binding [IDA]
    sequence-specific DNA binding [IEA]
    ecdysteroid hormone receptor activity [IDA][NAS]
    juvenile hormone binding [TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDNCDQDASF RLSHIKEEVK PDISQLNDSN NSSFSPKAES PVPFMQAMSM VHVLPGSNSA  60
   61 SSNNNSAGDA QMAQAPNSAG GSAAAAVQQQ YPPNHPLSGS KHLCSICGDR ASGKHYGVYS 120
  121 CEGCKGFFKR TVRKDLTYAC RENRNCIIDK RQRNRCQYCR YQKCLTCGMK REAVQEERQR 180
  181 GARNAAGRLS ASGGGSSGPG SVGGSSSQGG GGGGGVSGGM GSGNGSDDFM TNSVSRDFSI 240
  241 ERIIEAEQRA ETQCGDRALT FLRVGPYSTV QPDYKGAVSA LCQVVNKQLF QMVEYARMMP 300
  301 HFAQVPLDDQ VILLKAAWIE LLIANVAWCS IVSLDDGGAG GGGGGLGHDG SFERRSPGLQ 360
  361 PQQLFLNQSF SYHRNSAIKA GVSAIFDRIL SELSVKMKRL NLDRRELSCL KAIILYNPDI 420
  421 RGIKSRAEIE MCREKVYACL DEHCRLEHPG DDGRFAQLLL RLPALRSISL KCQDHLFLFR 480
  481 ITSDRPLEEL FLEQLEAPPP PGLAMKLE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..99] deduced N/A No confident structure predictions are available.
    2 View Details [100..206] PSI-BLAST 22.0 Crystal Structure of Vitmain D Receptor and 9-cis Retinoic Acid Receptor DNA-Binding Domains Bound to a DR3 Response Element
    3 View Details [207..508] PSI-BLAST 41.69897 Ultraspiracle protein, usp


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle