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Protein Overview: FBpp0298002, elav-PA

General Information:
Name(s) found: FBpp0298002 [FlyBase]
elav-PA / FBpp0070086 [FlyBase]
Description(s) found:
Found 35 descriptions.
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  • type=protein; loc=X:complement(411825..413275,415473..415473); ID=FBpp0298002; name=elav-PD; parent=FBgn0260400,FBtr0307173; dbxref=REFSEQ:NP_001245447,GB_protein:AFH07163,FlyBase:FBpp0298002,FlyBase_Annotation_IDs:CG4262-PD; MD5=e9c74059cb29a29d1eeab1443064b6e2; length=483; release=r5.56; species=Dmel; [FlyBase]
  • The gene embryonic lethal abnormal vision is referred to in FlyBase by the symbol Dmel\elav (CG4262, FBgn0260400). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:410878..417259. It has the cytological map location 1B7-1B8. There is experimental evidence that it has the molecular function</span>: RNA binding. There is experimental evidence that it is involved in the biological process</span>: central nervous system development; negative regulation of mRNA 3'-end processing. 75 alleles are reported. The phenotypes of these alleles are annotated with 15 unique terms, many of which group under: adult segment; nervous system; embryonic nervous system; multi-cell-component structure; adult brain; embryonic neuron; external compound sense organ; supraesophageal ganglion neuron; commissure; peripheral nervous system. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 483 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][TAS]
    Cajal body [IDA]
    Biological Process: RNA metabolic process [NAS]
    central nervous system development [IMP]
    nervous system development [NAS]
    negative regulation of mRNA 3'-end processing [IDA]
    Molecular Function: nucleotide binding [IEA]
    RNA binding [IDA]
    mRNA binding [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDFIMANTGA GGGVDTQAQL MQSAAAAAAV AATNAAAAPV QNAAAVAAAA QLQQQQVQQA  60
   61 ILQVQQQQTQ QAVAAAAAAV TQQLQQQQQA VVAQQAVVQQ QQQQAAAVVQ QAAVQQAVVP 120
  121 QPQQAQPNTN GNAGSGSQNG SNGSTETRTN LIVNYLPQTM TEDEIRSLFS SVGEIESVKL 180
  181 IRDKSQVYID PLNPQAPSKG QSLGYGFVNY VRPQDAEQAV NVLNGLRLQN KTIKVSFARP 240
  241 SSDAIKGANL YVSGLPKTMT QQELEAIFAP FGAIITSRIL QNAGNDTQTK GVGFIRFDKR 300
  301 EEATRAIIAL NGTTPSSCTD PIVVKFSNTP GSTSKIIQPQ LPAFLNPQLV RRIGGAMHTP 360
  361 VNKGLARFSP MAGDMLDVML PNGLGAAAAA ATTLASGPGG AYPIFIYNLA PETEEAALWQ 420
  421 LFGPFGAVQS VKIVKDPTTN QCKGYGFVSM TNYDEAAMAI RALNGYTMGN RVLQVSFKTN 480
  481 KAK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..142] FFAS03 1.42 No description for 2j63A was found.
    2 View Details [143..238] PSI-BLAST 35.0 Hu antigen D (Hud)
    3 View Details [239..383] FFAS03 4.13 CBP20, 20KDa nuclear cap-binding protein
    4 View Details [384..483] PSI-BLAST 21.522879 Hu antigen C (Huc)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • RNA binding
    		•  5.15097136329571 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.92126426323641 bayes_pls_golite062009
  • mRNA binding
    		•  4.05281507540116 bayes_pls_golite062009
  • binding
    		•  3.64400841800969 bayes_pls_golite062009
    		• 2.60920363363072 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.18211199677674 bayes_pls_golite062009
  • DNA binding
    		•  1.98418556946403 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  1.46469774223879 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  1.36691748240059 bayes_pls_golite062009
  • protein binding
    		•  1.12215421354121 bayes_pls_golite062009
  • transcription factor activity
    		•  1.07843408116687 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.824614388276642 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.383589644462932 bayes_pls_golite062009
    3
    Term Confidence Notes
  • RNA binding
    		•  4.74219150342477 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.65259034341669 bayes_pls_golite062009
  • mRNA binding
    		•  3.63162433534903 bayes_pls_golite062009
  • binding
    		•  3.48033873254013 bayes_pls_golite062009
    		• 2.38034004712143 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.2045206027152 bayes_pls_golite062009
  • DNA binding
    		•  1.99030664201171 bayes_pls_golite062009
  • transcription factor activity
    		•  1.09958329302628 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  1.08300488237934 bayes_pls_golite062009
  • protein binding
    		•  1.05805521997665 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  0.960399311787502 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.462558743683805 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.327072171076297 bayes_pls_golite062009
    4
    Term Confidence Notes
  • RNA binding
    		•  5.15097136329571 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.92126426323641 bayes_pls_golite062009
  • mRNA binding
    		•  4.05281507540116 bayes_pls_golite062009
  • binding
    		•  3.64400841800969 bayes_pls_golite062009
    		• 2.60920363363072 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.18211199677674 bayes_pls_golite062009
  • DNA binding
    		•  1.98418556946403 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  1.46469774223879 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  1.36691748240059 bayes_pls_golite062009
  • protein binding
    		•  1.12215421354121 bayes_pls_golite062009
  • transcription factor activity
    		•  1.07843408116687 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.824614388276642 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.383589644462932 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.63

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle