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Protein Overview: CG11876-PD, CG11...

General Information:
Name(s) found: CG11876-PD / FBpp0084738 [FlyBase]
CG11876-PA / FBpp0084735 [FlyBase]
Description(s) found:
Found 34 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG11876 (CG11876, FBgn0039635). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:24938793..24941918. It has the cytological map location 98F10. Based on sequence similarity, it is predicted to have molecular function</span>: pyruvate dehydrogenase (acetyl-transferring) activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: pyruvate metabolic process. 3 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
  • This gene is referred to in FlyBase by the symbol Dmel\CG11876 (CG11876, FBgn0039635). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:24938793..24941918. It has the cytological map location 98F10. Based on sequence similarity, it is predicted to have molecular function</span>: pyruvate dehydrogenase (acetyl-transferring) activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: pyruvate metabolic process. 3 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 365 amino acids

    Gene Ontology:
    Cellular Component: lipid particle [IDA]
    pyruvate dehydrogenase complex [ISS]
    Biological Process: pyruvate metabolic process [ISS]
    Molecular Function: pyruvate dehydrogenase (acetyl-transferring) activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRTRLIQAA SSAQRAFSTS QKALAAKQMT VRDALNSALD DELARDDRVF ILGEEVAQYD  60
   61 GAYKVSRGLW KKYGDKRVID TPITEMGFAG IAVGAAMAGL RPVCEFMTWN FSMQAIDHII 120
  121 NSAAKTFYMS AGAVNVPIVF RGPNGAASGV AAQHSQCFAA WYAHCPGLKV LSPYDAEDAR 180
  181 GLLKSAIRDP DPVVFLENEL VYGTAFPVAD NVADKDFLVP IGKAKVMRPG KDITLVAHSK 240
  241 AVETSLLAAA ELAKKGIEAE VINLRSIRPL DTATIFASVR KTHHLVTVEN GWPQHGVGAE 300
  301 ICARIMEDQT FFELDAPVWR CAGVDVPMPY AKTLEAHALP RVQDLVEATL KVLGGKVGKA 360
  361 AAANK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..365] PSI-BLAST 91.69897 E1-beta subunit of pyruvate dehydrogenase, Pyr module; E1-beta subunit of pyruvate dehydrogenase, C-domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • pyruvate dehydrogenase activity
    		•  11.3856674722026 bayes_pls_golite062009
  • pyruvate dehydrogenase (acetyl-transferring) activity
    		•  11.0549577473177 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
    		•  10.8180381281695 bayes_pls_golite062009
  • 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity
    		•  7.00951713446616 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  5.65146926050423 bayes_pls_golite062009
  • acetolactate synthase activity
    		•  4.51986503762195 bayes_pls_golite062009
  • alpha-ketoacid dehydrogenase activity
    		•  2.61614462349133 bayes_pls_golite062009
  • transferase activity, transferring aldehyde or ketonic groups
    		•  2.21959520697519 bayes_pls_golite062009
  • transketolase activity
    		•  2.20554088536433 bayes_pls_golite062009
  • transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
    		•  0.667418924427388 bayes_pls_golite062009
  • binding
    		•  0.551586872853971 bayes_pls_golite062009
  • catalytic activity
    		•  0.545407789079971 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.281475773435032 bayes_pls_golite062009
  • pyruvate decarboxylase activity
    		•  0.198062360371269 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle