Protein Overview: Mes-4-PA

General Information:
Name(s) found:	Mes-4-PA / FBpp0084636 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|94400569\|gb\|ABF17912.1\| FI01019p [Drosophila melanogaster] [NCBI NR] gi\|29427833\|sp\|Q8MT36.2\|MES4_DROME RecName: Full=Probable histone-lysine N-methyltransferase Mes-4; AltName: Full=Maternal-effect sterile 4 homolog [NCBI NR] gi\|24650756\|ref\|NP_733239.1\| Mes-4 [Drosophila melanogaster] [NCBI NR] gi\|23172478\|gb\|AAF56762.2\| Mes-4 [Drosophila melanogaster] [NCBI NR] Probable histone-lysine N-methyltransferase Mes-4 OS=Drosophila melanogaster GN=Mes-4 PE=1 SV=2 [Swiss-Prot] The gene Mes-4 is referred to in FlyBase by the symbol Dmel\Mes-4 (CG4976, FBgn0039559). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:23758704..23763571. It has the cytological map location 98B6. There is experimental evidence that it has the molecular function</span>: histone methyltransferase activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: germ-line sex determination; gene silencing. 7 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase] >CG4976-PA translation from_gene[CG4976 Mes-4 FBgn0039559] seq_release:3 mol_weight=159030 cds_boundaries:(3R:23,748,273..23,752,837[-]) aa_length:1427 transcript_info:[CG4976-RA seq_release:3] gene_info:[gene symbol:Mes-4 FBgn0039559 gene_boundaries:( [hmr_yeast5_DM3-1_pombe.fasta] (Q8MT36) Potential histone methyltransferase Mes-4 (Maternal-effect sterile 4) [DrosMelano7227.FASTAC.txt] CG4976-PA [Drosophila melanogaster]gi\|24650756\|ref\|NP_733239.1\| CG4976-PA [Drosophila melanogaster]gi\|29427833\|sp\|Q8MT36\|MES4_DROME Potential histone methyltransferase Mes-4 (Maternal-effect sterile 4) [nrdb_11152004_Chlamydomonas] type=protein; loc=3R:complement(23758905..23759036,23759095..23759220,23759285..23761715,23761784..23763059,23763153..23763471); ID=FBpp0084636; name=Mes-4-PA; parent=FBgn0039559,FBtr0085267; dbxref=FlyBase:FBpp0084636,FlyBase_Annotation_IDs:CG4976-PA,GB_ [fly-100309-contam.fasta] FI01019p [Drosophila melanogaster] [nr-271106-contam.fasta] Mes-4 CG4976-PA [Drosophila melanogaster] [nr-271106-contam.fasta] Probable histone methyltransferase Mes-4 (Maternal-effect sterile 4) [nr-271106-contam.fasta] CG4976-PA [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=3R:complement(23758905..23759036,23759095..23759220,23759285..23761715,23761784..23763059,23763153..23763471); ID=FBpp0084636; name=Mes-4-PA; parent=FBgn0039559,FBtr0085267; dbxref=FlyBase:FBpp0084636,FlyBase_Annotation_IDs:CG4976-PA,GB_protein:AAF56762.2,REFSEQ:NP_733239,GB_protein:AAF56762; MD5=6a072c387235dcc3f2517e08bb3c1130; length=1427; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=3R:complement(23758905..23759036,23759095..23759220,23759285..23761715,23761784..23763059,23763153..23763471); ID=FBpp0084636; name=Mes-4-PA; parent=FBgn0039559,FBtr0085267; dbxref=FlyBase:FBpp0084636,FlyBase_Annotation_IDs:CG4976-PA,GB_protein:AAF56762.2,REFSEQ:NP_733239,GB_protein:AAF56762; MD5=6a072c387235dcc3f2517e08bb3c1130; length=1427; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] type=protein; loc=3R:complement(23758905..23759036,23759095..23759220,23759285..23761715,23761784..23763059,23763153..23763471); ID=FBpp0084636; name=Mes-4-PA; parent=FBgn0039559,FBtr0085267; dbxref=FlyBase:FBpp0084636,FlyBase_Annotation_IDs:CG4976-PA,GB_protein:AAF56762.2,REFSEQ:NP_733239,GB_protein:AAF56762,FlyMine:FBpp0084636,modMine:FBpp0084636; MD5=6a072c387235dcc3f2517e08bb3c1130; length=1427; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=3R:complement(join(27937431..27937749,27936062..27937337,27933563..27935993,27933373..27933498,27933183..27933314)); ID=FBpp0084636; name=Mes-4-PA; parent=FBgn0039559,FBtr0085267; dbxref=FlyBase:FBpp0084636,FlyBase_Annotation_IDs:CG4976-PA,GB_protein:AAF56762.2,REFSEQ:NP_733239,GB_protein:AAF56762,FlyMine:FBpp0084636,modMine:FBpp0084636; MD5=6a072c387235dcc3f2517e08bb3c1130; length=1427; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=3R:complement(join(27937431..27937749,27936062..27937337,27933563..27935993,27933373..27933498,27933183..27933314)); ID=FBpp0084636; name=Mes-4-PA; parent=FBgn0039559,FBtr0085267; dbxref=FlyBase:FBpp0084636,FlyBase_Annotation_IDs:CG4976-PA,GB_protein:AAF56762.2,REFSEQ:NP_733239,GB_protein:AAF56762,FlyMine:FBpp0084636,modMine:FBpp0084636; MD5=6a072c387235dcc3f2517e08bb3c1130; length=1427; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] FBpp0084636 type=protein; loc=3R:complement(join(27937431..27937749,27936062..27937337,27933563..27935993,27933373..27933498,27933183..27933314)); ID=FBpp0084636; name=Mes-4-PA; parent=FBgn0039559,FBtr0085267; dbxref=FlyBase:FBpp0084636,FlyBase_Annotation_IDs:CG4976-PA,GB_protein:AAF56762.2,REFSEQ:NP_733239,GB_protein:AAF56762,FlyMine:FBpp0084636,modMine:FBpp0084636; MD5=6a072c387235dcc3f2517e08bb3c1130; length=1427; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=3R:complement(join(27937431..27937749,27936062..27937337,27933563..27935993,27933373..27933498,27933183..27933314)); ID=FBpp0084636; name=NSD-PA; parent=FBgn0039559,FBtr0085267; dbxref=FlyBase:FBpp0084636,FlyBase_Annotation_IDs:CG4976-PA,GB_protein:AAF56762.2,REFSEQ:NP_733239,GB_protein:AAF56762,UniProt/Swiss-Prot:Q8MT36,FlyMine:FBpp0084636,modMine:FBpp0084636; MD5=6a072c387235dcc3f2517e08bb3c1130; length=1427; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	1427 amino acids
Gene Ontology:
Cellular Component:	nuclear chromosome [ISS]
Biological Process:	gene silencing [ISS] germ-line sex determination [ISS]
Molecular Function:	zinc ion binding [IEA] transcription cofactor activity [ISS] histone methyltransferase activity [IDA][ISS] histone-lysine N-methyltransferase activity [IEA] transcription factor binding [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLSTDAHSE IEGDAAHGNV LCNSASDSLT ATDEVAAGND ESVATEGDDV EIPRDTNNST  60
   61 PVRLLDKPGQ NPVQNGAQPA AEESELESQR QTPVQKQQQQ RVSMVNRKRD LINLQSALSP 120
  121 KYIGYANANS PTPLSDSDDT IRTTRRRVNQ AAALNNSSAG ETLAHDNASP RTPGGGGGGG 180
  181 GDDSANQLLS KTYMSPIEKL LIKNGASSPN STGFEAGSED LGIRPIVRKH VKRKMKRVPK 240
  241 AKVTLELDEK NQQEVDEKSV KTEPIDEEVD RTDEAPTQEA QTTAISIKSE TEAEHKAAVD 300
  301 VHIKQEDTIR LDIVNNPVES TSIVITEEPK DLEKSTEELA FALPLASSTE VDLKSPPDLS 360
  361 STALATSIKS PSSVSIDSAK GLSIVTDPGW PTYQVGDLFW GKVFSYCFWP CMVCPDPLGQ 420
  421 IVGNMPSHPQ RSSLDNANVP IQVHVRFFAD NGRRNWIKPE NLLTFAGLKA FDDMREELRI 480
  481 KHGPKSAKYR QMVPKRTKVV IWRQAIEEAQ AMTQIPYSDR LEKFYQTYEN VVTLNRQKRK 540
  541 RTKYMMQDTS DVGSSLYDST DNLHNKQGTQ LLAVKRERSE SPFSPAFSPV KSKNEKRAKR 600
  601 RKLSNGTEAD TGSNSMAVTP SQTETTVDSS AYENPEFRQL LSAVMEYVMM NRSDEKVEKV 660
  661 LLSVVSNIWS LKQIQLRELE RDLASGEIEE PLGSSVVGRG SGVGTIKRLS NRLMTMMVRR 720
  721 SMTPVVTPST TPAPSEPDRR LSEPPKTKKP VNRPIEEVIE DILQLDSKYL FRGLSREPIC 780
  781 KYCYQAGSDL VRCSRTCSSW LHADCLERKV TGAPMPKIGS RKALVIPPTS KSPSPDEDHV 840
  841 TADAKEVVAV GTSLVCHECN VGEPEGCVIC HQVESPAVPS TPRKEDSSSH TPIEDKLLTC 900
  901 SQPMCGKRFH TSCCKYWPQA SSSKHSARCP RHVCHTCVSD DPSGKFQQLG SSKLAKCVRC 960
  961 PATYHQLSKC IPAGTQMLNT TNIICPRHNI AKADAHVNVL WCYICVKGGE LVCCETCPIA1020
 1021 VHAHCRNIPI KTNESYICEE CESGRLPLYG EIVWAKFNNF RWWPAIILPP TEVPSNILKK1080
 1081 AHGENDFVVR FFGTHDHGWI SRRRVYLYIE GDTGDGHKTK SQLFRNYTTG VEEASRFLPI1140
 1141 IKARRQEQDM ERQSGNKLHP PPYVKIKTNK AVPPLRFSQN LEDLSTCNCL PVDEHPCGPE1200
 1201 AGCLNRMLFN ECNPEYCKAG SLCENRMFEQ RKSPRLEVVY MNERGFGLVN REPIAVGDFV1260
 1261 IEYVGEVINH AEFQRRMEQK QRDRDENYYF LGVEKDFIID AGPKGNLARF MNHSCEPNCE1320
 1321 TQKWTVNCIH RVGIFAIKDI PVNSELTFNY LWDDLMNNSK KACFCGAKRC SGEIGGKLKD1380
 1381 DAVKAHAKLK QMRRAKASAV RIHVKPKKTP KVKHISADDE PMDAKDE

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..216]	MSA	2.122996	View MSA. No confident structure predictions are available.
2	View Details	[217..365]	deduced	N/A	No confident structure predictions are available.
3	View Details	[366..515]	PSI-BLAST	7.0	No description for 2gfuA was found.
4	View Details	[516..690]	deduced	N/A	No confident structure predictions are available.
5	View Details	[691..812]	FFAS03	1.08	Solution Structure of The C1 Domain of The Human Diacylglycerol Kinase Delta
6	View Details	[813..1014]	PSI-BLAST	3.09691	Type 1 insulin-like growth factor receptor extracellular domain; Type 1 insulin-like growth factor receptor Cys-rich domain
7	View Details	[1015..1122]	PSI-BLAST	6.221849	No description for 2daqA was found.
8	View Details	[1123..1427]	PSI-BLAST	14.39794	No description for 2igqA was found.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: Mes-4-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: