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Protein Overview: Mes-4-PA

General Information:
Name(s) found: Mes-4-PA / FBpp0084636 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene Mes-4 is referred to in FlyBase by the symbol Dmel\Mes-4 (CG4976, FBgn0039559). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:23758704..23763571. It has the cytological map location 98B6. There is experimental evidence that it has the molecular function</span>: histone methyltransferase activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: germ-line sex determination; gene silencing. 7 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1427 amino acids

    Gene Ontology:
    Cellular Component: nuclear chromosome [ISS]
    Biological Process: gene silencing [ISS]
    germ-line sex determination [ISS]
    Molecular Function: zinc ion binding [IEA]
    transcription cofactor activity [ISS]
    histone methyltransferase activity [IDA][ISS]
    histone-lysine N-methyltransferase activity [IEA]
    transcription factor binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLSTDAHSE IEGDAAHGNV LCNSASDSLT ATDEVAAGND ESVATEGDDV EIPRDTNNST  60
   61 PVRLLDKPGQ NPVQNGAQPA AEESELESQR QTPVQKQQQQ RVSMVNRKRD LINLQSALSP 120
  121 KYIGYANANS PTPLSDSDDT IRTTRRRVNQ AAALNNSSAG ETLAHDNASP RTPGGGGGGG 180
  181 GDDSANQLLS KTYMSPIEKL LIKNGASSPN STGFEAGSED LGIRPIVRKH VKRKMKRVPK 240
  241 AKVTLELDEK NQQEVDEKSV KTEPIDEEVD RTDEAPTQEA QTTAISIKSE TEAEHKAAVD 300
  301 VHIKQEDTIR LDIVNNPVES TSIVITEEPK DLEKSTEELA FALPLASSTE VDLKSPPDLS 360
  361 STALATSIKS PSSVSIDSAK GLSIVTDPGW PTYQVGDLFW GKVFSYCFWP CMVCPDPLGQ 420
  421 IVGNMPSHPQ RSSLDNANVP IQVHVRFFAD NGRRNWIKPE NLLTFAGLKA FDDMREELRI 480
  481 KHGPKSAKYR QMVPKRTKVV IWRQAIEEAQ AMTQIPYSDR LEKFYQTYEN VVTLNRQKRK 540
  541 RTKYMMQDTS DVGSSLYDST DNLHNKQGTQ LLAVKRERSE SPFSPAFSPV KSKNEKRAKR 600
  601 RKLSNGTEAD TGSNSMAVTP SQTETTVDSS AYENPEFRQL LSAVMEYVMM NRSDEKVEKV 660
  661 LLSVVSNIWS LKQIQLRELE RDLASGEIEE PLGSSVVGRG SGVGTIKRLS NRLMTMMVRR 720
  721 SMTPVVTPST TPAPSEPDRR LSEPPKTKKP VNRPIEEVIE DILQLDSKYL FRGLSREPIC 780
  781 KYCYQAGSDL VRCSRTCSSW LHADCLERKV TGAPMPKIGS RKALVIPPTS KSPSPDEDHV 840
  841 TADAKEVVAV GTSLVCHECN VGEPEGCVIC HQVESPAVPS TPRKEDSSSH TPIEDKLLTC 900
  901 SQPMCGKRFH TSCCKYWPQA SSSKHSARCP RHVCHTCVSD DPSGKFQQLG SSKLAKCVRC 960
  961 PATYHQLSKC IPAGTQMLNT TNIICPRHNI AKADAHVNVL WCYICVKGGE LVCCETCPIA1020
 1021 VHAHCRNIPI KTNESYICEE CESGRLPLYG EIVWAKFNNF RWWPAIILPP TEVPSNILKK1080
 1081 AHGENDFVVR FFGTHDHGWI SRRRVYLYIE GDTGDGHKTK SQLFRNYTTG VEEASRFLPI1140
 1141 IKARRQEQDM ERQSGNKLHP PPYVKIKTNK AVPPLRFSQN LEDLSTCNCL PVDEHPCGPE1200
 1201 AGCLNRMLFN ECNPEYCKAG SLCENRMFEQ RKSPRLEVVY MNERGFGLVN REPIAVGDFV1260
 1261 IEYVGEVINH AEFQRRMEQK QRDRDENYYF LGVEKDFIID AGPKGNLARF MNHSCEPNCE1320
 1321 TQKWTVNCIH RVGIFAIKDI PVNSELTFNY LWDDLMNNSK KACFCGAKRC SGEIGGKLKD1380
 1381 DAVKAHAKLK QMRRAKASAV RIHVKPKKTP KVKHISADDE PMDAKDE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..216] MSA 2.122996 View MSA. No confident structure predictions are available.
    2 View Details [217..365] deduced N/A No confident structure predictions are available.
    3 View Details [366..515] PSI-BLAST 7.0 No description for 2gfuA was found.
    4 View Details [516..690] deduced N/A No confident structure predictions are available.
    5 View Details [691..812] FFAS03 1.08 Solution Structure of The C1 Domain of The Human Diacylglycerol Kinase Delta
    6 View Details [813..1014] PSI-BLAST 3.09691 Type 1 insulin-like growth factor receptor extracellular domain; Type 1 insulin-like growth factor receptor Cys-rich domain
    7 View Details [1015..1122] PSI-BLAST 6.221849 No description for 2daqA was found.
    8 View Details [1123..1427] PSI-BLAST 14.39794 No description for 2igqA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • binding
    		•  3.28414942114785 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.3594533055858 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.81629978306019 bayes_pls_golite062009
  • DNA binding
    		•  1.66283166928615 bayes_pls_golite062009
  • protein binding
    		•  1.11019507232162 bayes_pls_golite062009
  • transcription factor activity
    		•  1.06673352248936 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.675335570837432 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.671077806185763 bayes_pls_golite062009
  • catalytic activity
    		•  0.216721136299042 bayes_pls_golite062009
    6
    Term Confidence Notes
  • binding
    		•  3.68068574919022 bayes_pls_golite062009
  • protein binding
    		•  1.89567090642897 bayes_pls_golite062009
  • growth factor binding
    		•  1.78764054532907 bayes_pls_golite062009
  • insulin-like growth factor II binding
    		•  1.61780711385 bayes_pls_golite062009
  • insulin-like growth factor binding
    		•  1.14132310810584 bayes_pls_golite062009
  • insulin-like growth factor I binding
    		•  0.715089814495633 bayes_pls_golite062009
  • catalytic activity
    		•  0.271811389148807 bayes_pls_golite062009
  • protein tyrosine phosphatase activator activity
    		•  0.225770989190604 bayes_pls_golite062009
    7
    Term Confidence Notes
  • binding
    		•  3.61058244718631 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.06808416304746 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.87915752987189 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.99409428066103 bayes_pls_golite062009
  • DNA binding
    		•  1.99122459938277 bayes_pls_golite062009
  • protein binding
    		•  1.6693185254069 bayes_pls_golite062009
  • chromatin binding
    		•  1.64603851743141 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.55732936245077 bayes_pls_golite062009
  • transcription factor binding
    		•  1.41819104451617 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.23808324966394 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  1.09290857177628 bayes_pls_golite062009
  • transcription factor activity
    		•  1.09191102986161 bayes_pls_golite062009
  • methylated histone residue binding
    		•  0.93051370247257 bayes_pls_golite062009
  • protein-lysine N-methyltransferase activity
    		•  0.72077437792468 bayes_pls_golite062009
  • histone-lysine N-methyltransferase activity
    		•  0.72077437792468 bayes_pls_golite062009
  • lysine N-methyltransferase activity
    		•  0.72077437792468 bayes_pls_golite062009
  • retinoid X receptor binding
    		•  0.47657909093375 bayes_pls_golite062009
  • retinoic acid receptor binding
    		•  0.43555270589681 bayes_pls_golite062009
  • unmethylated CpG binding
    		•  0.300145179661899 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0981008314930329 bayes_pls_golite062009
  • fibroblast growth factor binding
    		•  0.031681227093159 bayes_pls_golite062009
    8 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle