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Protein Overview: TfIIA-L-PA

General Information:
Name(s) found: TfIIA-L-PA / FBpp0084525 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene Transcription factor IIA L is referred to in FlyBase by the symbol Dmel\TfIIA-L (CG5930, FBgn0011289). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:23076834..23082186. It has the cytological map location 97E11. Based on sequence similarity, it is predicted to have molecular function</span>: general RNA polymerase II transcription factor activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: transcription initiation from RNA polymerase II promoter. 9 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 366 amino acids

    Gene Ontology:
    Cellular Component: nucleus [NAS]
    transcription factor TFIIA complex [ISS]
    Biological Process: transcription initiation from RNA polymerase II promoter [ISS]
    regulation of transcription from RNA polymerase II promoter [NAS]
    Molecular Function: general RNA polymerase II transcription factor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALCQTSVLK VYHAVIEDVI TNVRDAFLDE GVDEQVLQEM KQVWRNKLLA SKAVELSPDS  60
   61 GDGSHPPPIV ANNPKSHKAA NAKAKKAAAA TAVTSHQHIG GNSSMSSLVG LKSSAGMAAG 120
  121 SGIRNGLVPI KQEVNSQNPP PLHPTSAASM MQKQQQAASS GQGSIPIVAT LDPNRIMPVN 180
  181 ITLPSPAGSA SSESRVLTIQ VPASALQENQ LTQILTAHLI SSIMSLPTTL ASSVLQQHVN 240
  241 AALSSANHQK TLAAAKQLDG ALDSSDEDES EESDDNIDND DDDDLDKDDD EDAEHEDAAE 300
  301 EEPLNSEDDV TDEDSAEMFD TDNVIVCQYD KITRSRNKWK FYLKDGIMNM RGKDYVFQKS 360
  361 NGDAEW

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..140] FFAS03 4.53 Structure of a Yeast TFIIA/TBP/TATA-box DNA Complex
    2 View Details [141..281] PSI-BLAST 6.69897 Sec24
    3 View Details [282..366] PSI-BLAST 40.69897 HUMAN TFIIA/TBP/DNA COMPLEX

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • general RNA polymerase II transcription factor activity
    		•  10.9702263885595 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  5.06993130505706 bayes_pls_golite062009
  • transcription regulator activity
    		•  4.7915315980149 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.26583234267697 bayes_pls_golite062009
  • DNA binding
    		•  2.12151270115091 bayes_pls_golite062009
  • transcription coactivator activity
    		•  2.10703866415858 bayes_pls_golite062009
  • binding
    		•  1.9212205923594 bayes_pls_golite062009
  • transcription activator activity
    		•  1.42377454899217 bayes_pls_golite062009
  • transcription factor binding
    		•  1.31659763916181 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.15899255380593 bayes_pls_golite062009
  • protein binding
    		•  0.497114544861103 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle