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View Structure Prediction Details

Protein: TfIIA-L-PA
Organism: Drosophila melanogaster
Length: 366 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TfIIA-L-PA.

Description E-value Query
Range
Subject
Range
gi|542595, gi|17... - pir||A49076 transcription factor TFIIA-L - fruit fly (Drosophila melanogaster), sp|P52654|T2AA_DROM...
gi|452955 - gi|452955|gb|AAB28821.1| TFIIA-L [Drosophila sp.]
267.0 [0..1] [366..1]

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Predicted Domain #1
Region A:
Residues: [1-140]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALCQTSVLK VYHAVIEDVI TNVRDAFLDE GVDEQVLQEM KQVWRNKLLA SKAVELSPDS  60
   61 GDGSHPPPIV ANNPKSHKAA NAKAKKAAAA TAVTSHQHIG GNSSMSSLVG LKSSAGMAAG 120
  121 SGIRNGLVPI KQEVNSQNPP 

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.53
Match: 1rm1C
Description: Structure of a Yeast TFIIA/TBP/TATA-box DNA Complex
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [141-281]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLHPTSAASM MQKQQQAASS GQGSIPIVAT LDPNRIMPVN ITLPSPAGSA SSESRVLTIQ  60
   61 VPASALQENQ LTQILTAHLI SSIMSLPTTL ASSVLQQHVN AALSSANHQK TLAAAKQLDG 120
  121 ALDSSDEDES EESDDNIDND D

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.69897
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [282-366]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDDLDKDDDE DAEHEDAAEE EPLNSEDDVT DEDSAEMFDT DNVIVCQYDK ITRSRNKWKF  60
   61 YLKDGIMNMR GKDYVFQKSN GDAEW

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 40.69897
Match: 1nvpC
Description: HUMAN TFIIA/TBP/DNA COMPLEX
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 10.9702263885595 bayes_pls_golite062009
RNA polymerase II transcription factor activity 5.06993130505706 bayes_pls_golite062009
transcription regulator activity 4.7915315980149 bayes_pls_golite062009
nucleic acid binding 2.26583234267697 bayes_pls_golite062009
DNA binding 2.12151270115091 bayes_pls_golite062009
transcription coactivator activity 2.10703866415858 bayes_pls_golite062009
binding 1.9212205923594 bayes_pls_golite062009
transcription activator activity 1.42377454899217 bayes_pls_golite062009
transcription factor binding 1.31659763916181 bayes_pls_golite062009
transcription cofactor activity 1.15899255380593 bayes_pls_golite062009
protein binding 0.497114544861103 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle