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Protein Overview: FBpp0303188, Tl-PB

General Information:
Name(s) found: FBpp0303188 [FlyBase]
Tl-PB / FBpp0084431 [FlyBase]
Description(s) found:
Found 38 descriptions.
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  • type=protein; loc=3R:join(22663459..22664678,22664796..22666869); ID=FBpp0303188; name=Tl-PD; parent=FBgn0262473,FBtr0330155; dbxref=FlyBase:FBpp0303188,FlyBase_Annotation_IDs:CG5490-PD,REFSEQ:NP_733166,GB_protein:AAF56624; MD5=d2cdeaa04f3b449545ad80366aae48e1; length=1097; release=r5.56; species=Dmel; [FlyBase]
  • The gene Toll is referred to in FlyBase by the symbol Dmel\Tl (CG5490, FBgn0003717). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:22624765..22668125. It has the cytological map location 97D2. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: synapse assembly; antifungal humoral response; cytokinesis; dorsal/ventral axis specification; regulation of hemocyte differentiation; positive regulation of antibacterial peptide biosynthetic process; antimicrobial humoral response; hemocyte proliferation; positive regulation of antifungal peptide biosynthetic process. 160 alleles are reported. The phenotypes of these alleles are annotated with 23 unique terms, many of which group under: organ system; embryonic/larval hemocoel; hemocyte; anatomical structure; portion of tissue; integumentary system; podocyte; primordium; extended germ band embryo; cuticle; germ layer. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1097 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [NAS]
    integral to membrane [NAS]
    protein complex [IPI]
    intrinsic to membrane [IEA]
    Biological Process: Toll signaling pathway [NAS]
    hemocyte proliferation [IMP][TAS]
    signal transduction [IEA]
    zygotic specification of dorsal/ventral axis [NAS]
    hemopoiesis [TAS]
    embryonic pattern specification [TAS]
    regulation of hemocyte differentiation [IMP]
    cytokinesis [IMP]
    dorsal/ventral axis specification [IMP][NAS][TAS]
    response to fungus [TAS]
    positive regulation of antibacterial peptide biosynthetic process [IMP]
    defense response [NAS][TAS]
    positive regulation of antifungal peptide biosynthetic process [IMP]
    synapse assembly [IMP]
    response to bacterium [NAS]
    immune response [TAS]
    innate immune response [IEA][NAS][TAS]
    antimicrobial humoral response [IGI]
    defense response to fungus [TAS]
    antifungal humoral response [IMP]
    defense response to Gram-positive bacterium [TAS]
    regulation of melanization defense response [TAS]
    Molecular Function: transmembrane receptor activity [IEA][NAS]
    protein binding [IPI]
    cytokine binding [TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRLKAASEL ALLVIILQLL QWPGSEASFG RDACSEMSID GLCQCAPIMS EYEIICPANA  60
   61 ENPTFRLTIQ PKDYVQIMCN LTDTTDYQQL PKKLRIGEVD RVQMRRCMLP GHTPIASILD 120
  121 YLGIVSPTTL IFESDNLGMN ITRQHLDRLH GLKRFRFTTR RLTHIPANLL TDMRNLSHLE 180
  181 LRANIEEMPS HLFDDLENLE SIEFGSNKLR QMPRGIFGKM PKLKQLNLWS NQLHNLTKHD 240
  241 FEGATSVLGI DIHDNGIEQL PHDVFAHLTN VTDINLSANL FRSLPQGLFD HNKHLNEVRL 300
  301 MNNRVPLATL PSRLFANQPE LQILRLRAEL QSLPGDLFEH STQITNISLG DNLLKTLPAT 360
  361 LLEHQVNLLS LDLSNNRLTH LPDSLFAHTT NLTDLRLEDN LLTGISGDIF SNLGNLVTLV 420
  421 MSRNRLRTID SRAFVSTNGL RHLHLDHNDI DLQQPLLDIM LQTQINSPFG YMHGLLTLNL 480
  481 RNNSIIFVYN DWKNTMLQLR ELDLSYNNIS SLGYEDLAFL SQNRLHVNMT HNKIRRIALP 540
  541 EDVHLGEGYN NNLVHVDLND NPLVCDCTIL WFIQLVRGVH KPQYSRQFKL RTDRLVCSQP 600
  601 NVLEGTPVRQ IEPQTLICPL DFSDDPRERK CPRGCNCHVR TYDKALVINC HSGNLTHVPR 660
  661 LPNLHKNMQL MELHLENNTL LRLPSANTPG YESVTSLHLA GNNLTSIDVD QLPTNLTHLD 720
  721 ISWNHLQMLN ATVLGFLNRT MKWRSVKLSG NPWMCDCTAK PLLLFTQDNF ERIGDRNEMM 780
  781 CVNAEMPTRM VELSTNDICP AEKGVFIALA VVIALTGLLA GFTAALYYKF QTEIKIWLYA 840
  841 HNLLLWFVTE EDLDKDKKFD AFISYSHKDQ SFIEDYLVPQ LEHGPQKFQL CVHERDWLVG 900
  901 GHIPENIMRS VADSRRTIIV LSQNFIKSEW ARLEFRAAHR SALNEGRSRI IVIIYSDIGD 960
  961 VEKLDEELKA YLKMNTYLKW GDPWFWDKLR FALPHRRPVG NIGNGALIKT ALKGSTDDKL1020
 1021 ELIKPSPVTP PLTTPPAEAT KNPLVAQLNG VTPHQAIMIA NGKNGLTNLY TPNGKSHGNG1080
 1081 HINGAFIINT NAKQSDV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..151] PSI-BLAST 33.69897 No description for 2o6qA was found.
    2 View Details [152..846] PSI-BLAST 67.69897 The molecular structure of toll-like receptor 3 ligand binding domain
    3 View Details [847..1005] PSI-BLAST 42.0 Toll-like receptor 2, TLR2
    4 View Details [1006..1097] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • receptor activity
    		•  4.09933951703109 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  3.9640091493609 bayes_pls_golite062009
  • signal transducer activity
    		•  3.16173995936925 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.16173995936925 bayes_pls_golite062009
  • binding
    		•  2.31499720771829 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.15703057436966 bayes_pls_golite062009
  • protein binding
    		•  2.10005190551596 bayes_pls_golite062009
  • peptidoglycan binding
    		•  1.415118707351 bayes_pls_golite062009
  • lipopolysaccharide binding
    		•  1.34678160601175 bayes_pls_golite062009
  • RNA binding
    		•  1.00206771839286 bayes_pls_golite062009
    		• 0.778638092955701 bayes_pls_golite062009
  • receptor binding
    		•  0.656744722545366 bayes_pls_golite062009
  • DNA binding
    		•  0.447168637241888 bayes_pls_golite062009
    		• 0.023695617862085 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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