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View Structure Prediction Details

Protein: FBpp0303188, Tl-PB
Organism: Drosophila melanogaster
Length: 1097 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0303188, Tl-PB.

Description E-value Query
Range
Subject
Range
gi|34334899 - gi|34334899|gb|AAQ64936.1| Toll [Drosophila melanogaster]
648.0 [0..74] [1097..5]

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Predicted Domain #1
Region A:
Residues: [1-151]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRLKAASEL ALLVIILQLL QWPGSEASFG RDACSEMSID GLCQCAPIMS EYEIICPANA  60
   61 ENPTFRLTIQ PKDYVQIMCN LTDTTDYQQL PKKLRIGEVD RVQMRRCMLP GHTPIASILD 120
  121 YLGIVSPTTL IFESDNLGMN ITRQHLDRLH G

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 33.69897
Match: 2o6qA
Description: No description for 2o6qA was found.

Predicted Domain #2
Region A:
Residues: [152-846]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKRFRFTTRR LTHIPANLLT DMRNLSHLEL RANIEEMPSH LFDDLENLES IEFGSNKLRQ  60
   61 MPRGIFGKMP KLKQLNLWSN QLHNLTKHDF EGATSVLGID IHDNGIEQLP HDVFAHLTNV 120
  121 TDINLSANLF RSLPQGLFDH NKHLNEVRLM NNRVPLATLP SRLFANQPEL QILRLRAELQ 180
  181 SLPGDLFEHS TQITNISLGD NLLKTLPATL LEHQVNLLSL DLSNNRLTHL PDSLFAHTTN 240
  241 LTDLRLEDNL LTGISGDIFS NLGNLVTLVM SRNRLRTIDS RAFVSTNGLR HLHLDHNDID 300
  301 LQQPLLDIML QTQINSPFGY MHGLLTLNLR NNSIIFVYND WKNTMLQLRE LDLSYNNISS 360
  361 LGYEDLAFLS QNRLHVNMTH NKIRRIALPE DVHLGEGYNN NLVHVDLNDN PLVCDCTILW 420
  421 FIQLVRGVHK PQYSRQFKLR TDRLVCSQPN VLEGTPVRQI EPQTLICPLD FSDDPRERKC 480
  481 PRGCNCHVRT YDKALVINCH SGNLTHVPRL PNLHKNMQLM ELHLENNTLL RLPSANTPGY 540
  541 ESVTSLHLAG NNLTSIDVDQ LPTNLTHLDI SWNHLQMLNA TVLGFLNRTM KWRSVKLSGN 600
  601 PWMCDCTAKP LLLFTQDNFE RIGDRNEMMC VNAEMPTRMV ELSTNDICPA EKGVFIALAV 660
  661 VIALTGLLAG FTAALYYKFQ TEIKIWLYAH NLLLW

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 67.69897
Match: 2a0zA
Description: The molecular structure of toll-like receptor 3 ligand binding domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [847-1005]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FVTEEDLDKD KKFDAFISYS HKDQSFIEDY LVPQLEHGPQ KFQLCVHERD WLVGGHIPEN  60
   61 IMRSVADSRR TIIVLSQNFI KSEWARLEFR AAHRSALNEG RSRIIVIIYS DIGDVEKLDE 120
  121 ELKAYLKMNT YLKWGDPWFW DKLRFALPHR RPVGNIGNG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 42.0
Match: 1fywA
Description: Toll-like receptor 2, TLR2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor activity 4.09933951703109 bayes_pls_golite062009
transmembrane receptor activity 3.9640091493609 bayes_pls_golite062009
signal transducer activity 3.16173995936925 bayes_pls_golite062009
molecular transducer activity 3.16173995936925 bayes_pls_golite062009
binding 2.31499720771829 bayes_pls_golite062009
nucleic acid binding 2.15703057436966 bayes_pls_golite062009
protein binding 2.10005190551596 bayes_pls_golite062009
peptidoglycan binding 1.415118707351 bayes_pls_golite062009
lipopolysaccharide binding 1.34678160601175 bayes_pls_golite062009
RNA binding 1.00206771839286 bayes_pls_golite062009
0.778638092955701 bayes_pls_golite062009
receptor binding 0.656744722545366 bayes_pls_golite062009
DNA binding 0.447168637241888 bayes_pls_golite062009
0.023695617862085 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [1006-1097]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ALIKTALKGS TDDKLELIKP SPVTPPLTTP PAEATKNPLV AQLNGVTPHQ AIMIANGKNG  60
   61 LTNLYTPNGK SHGNGHINGA FIINTNAKQS DV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle