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Protein Overview: msi-PA

General Information:
Name(s) found: msi-PA / FBpp0084256 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • The gene musashi is referred to in FlyBase by the symbol Dmel\msi (CG5099, FBgn0011666). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:21344045..21428143. It has the cytological map location 96E2-96E4. Based on sequence similarity, it is predicted to have molecular function</span>: mRNA binding. There is experimental evidence that it is involved in the biological process</span>: stem cell maintenance; germ-line stem cell division; negative regulation of translation. 22 alleles are reported. The phenotypes of these alleles are annotated with: rhabdomere; testis sheath muscle; thecogen cell; testis; ommatidium; socket; external sensory organ. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 606 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: regulation of translation [TAS]
    stem cell maintenance [IMP]
    germ-line stem cell division [IMP]
    mRNA processing [ISS]
    negative regulation of translation [IMP][TAS]
    cell fate determination [TAS]
    Molecular Function: nucleotide binding [IEA]
    translation regulator activity [TAS]
    translation repressor activity, nucleic acid binding [TAS]
    mRNA binding [ISS][NAS][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHALQEGATV LHHQQPPPPT SGEDHLLTAD SFFYARSNPM ENAAAAAAAA AAGLIDPHHN  60
   61 RDLHQALVAS IANNSVAAIG GGLTTAAVLK SAAQQSQQAV QQNQNAVVVT PGLEQPKQEP 120
  121 AQQAALALLK ENVNASAGAG QNNGQAAMGG SNKSGSSGRS TPSLSGGSGS DPAPGKLFVG 180
  181 GLSWQTSSDK LKEYFNMFGT VTDVLIMKDP VTQRSRGFGF ITFQEPCTVE KVLKVPIHTL 240
  241 DGKKIDPKHA TPKNRPRQAN KTKKIFVGGV SQDTSAEEVK AYFSQFGPVE ETVMLMDQQT 300
  301 KRHRGFGFVT FENEDVVDRV CEIHFHTIKN KKVECKKAQP KEAVTPAAQL LQKRIMLGTL 360
  361 GVQLPTAPGQ LIGARGAGVA TMNPLAMLQN PTQLLQSPAA AAAAQQAALI SQNPFQVQNA 420
  421 AAAASIANQA GFGKLLTTYP QTALHSVRYA PYSIPASAAT ANAALMQAHQ AQSVAAAAHH 480
  481 HQQQQQQQHH HQQQTHNAHV AAAQQQQQSH HNAVSNPASQ AHSAAAAAAL AANAANGAGA 540
  541 AGAHSLAAAA QQAGLMAGNP LNAAAAAAAA AANPAAAYSN YALANVDMSS FQGVDWSTMY 600
  601 GMGMYV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..259] PSI-BLAST 49.39794 Nuclear ribonucleoprotein A1 (RNP A1, UP1)
    2 View Details [260..358] PSI-BLAST 9.69897 No description for 2go9A was found.
    3 View Details [359..516] PSI-BLAST 5.0 Sec24
    4 View Details [517..606] PSI-BLAST 23.0 poly(A) binding protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • RNA binding
    		•  3.75748736237159 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.9003829560934 bayes_pls_golite062009
  • mRNA binding
    		•  2.67679675039933 bayes_pls_golite062009
  • binding
    		•  2.30438455421982 bayes_pls_golite062009
    		• 0.61507045441317 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  0.61170301639809 bayes_pls_golite062009
  • protein binding
    		•  0.403675976995418 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.214300208089751 bayes_pls_golite062009
  • mRNA 5'-UTR binding
    		•  0.18283446592068 bayes_pls_golite062009
  • translation repressor activity, nucleic acid binding
    		•  0.0860748299027598 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  0.0800614106161897 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.46

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle