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Protein Overview: Hr96-PA

General Information:
Name(s) found: Hr96-PA / FBpp0084131 [FlyBase]
Description(s) found:
Found 25 descriptions.
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  • The gene Hormone receptor-like in 96 is referred to in FlyBase by the symbol Dmel\Hr96 (CG11783, FBgn0015240). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:20850961..20855075. It has the cytological map location 96B16-96B17. Based on sequence similarity, it is predicted to have molecular function</span>: transcription factor activity; ligand-dependent nuclear receptor activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: regulation of transcription, DNA-dependent. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 723 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS][NAS]
    Biological Process: regulation of transcription, DNA-dependent [IEA]
    Molecular Function: DNA binding [NAS]
    transcription factor activity [ISS]
    zinc ion binding [IEA]
    ligand-dependent nuclear receptor activity [ISS][NAS]
    steroid hormone receptor activity [IEA]
    sequence-specific DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPPKNCAVC GDKALGYNFN AVTCESCKAF FRRNALAKKQ FTCPFNQNCD ITVVTRRFCQ  60
   61 KCRLRKCLDI GMKSENIMSE EDKLIKRRKI ETNRAKRRLM ENGTDACDAD GGEERDHKAP 120
  121 ADSSSSNLDH YSGSQDSQSC GSADSGANGC SGRQASSPGT QVNPLQMTAE KIVDQIVSDP 180
  181 DRASQAINRL MRTQKEAISV MEKVISSQKD ALRLVSHLID YPGDALKIIS KFMNSPFNAL 240
  241 TVFTKFMSSP TDGVEIISKI VDSPADVVEF MQNLMHSPED AIDIMNKFMN TPAEALRILN 300
  301 RILSGGGANA AQQTADRKPL LDKEPAVKPA APAERADTVI QSMLGNSPPI SPHDAAVDLQ 360
  361 YHSPGVGEQP STSSSHPLPY IANSPDFDLK TFMQTNYNDE PSLDSDFSIN SIESVLSEVI 420
  421 RIEYQAFNSI QQAASRVKEE MSYGTQSTYG GCNSAANNSQ PHLQQPICAP STQQLDRELN 480
  481 EAEQMKLREL RLASEALYDP VDEDLSALMM GDDRIKPDDT RHNPKLLQLI NLTAVAIKRL 540
  541 IKMAKKITAF RDMCQEDQVA LLKGGCTEMM IMRSVMIYDD DRAAWKVPHT KENMGNIRTD 600
  601 LLKFAEGNIY EEHQKFITTF DEKWRMDENI ILIMCAIVLF TSARSRVIHK DVIRLEQNSY 660
  661 YYLLRRYLES VYSGCEARNA FIKLIQKISD VERLNKFIIN VYLNVNPSQV EPLLREIFDL 720
  721 KNH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..153] PSI-BLAST 23.09691 No description for 2hanB was found.
    2 View Details [154..389] deduced N/A No confident structure predictions are available.
    3 View Details [390..723] PSI-BLAST 41.69897 Thyroid hormone receptor alpha1 (TR-alpha1)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  4.00967542385368 bayes_pls_golite062009
  • DNA binding
    		•  3.60745514727532 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.47256374293954 bayes_pls_golite062009
  • binding
    		•  2.96409924710655 bayes_pls_golite062009
  • transcription activator activity
    		•  2.9532663930699 bayes_pls_golite062009
  • transcription factor activity
    		•  2.90769972671972 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.72967350701574 bayes_pls_golite062009
  • protein binding
    		•  2.44501340584871 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.40923942043513 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  1.49515149729803 bayes_pls_golite062009
  • transcription factor binding
    		•  1.38523780690867 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.26452462867497 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.68943696300126 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.58115018700114 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.256420113528322 bayes_pls_golite062009
  • catalytic activity
    		•  0.101795606736461 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  5.53061626347066 bayes_pls_golite062009
  • DNA binding
    		•  4.92165988569962 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.78024150262074 bayes_pls_golite062009
  • transcription activator activity
    		•  4.53302455129434 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  4.11614358606713 bayes_pls_golite062009
  • transcription factor activity
    		•  4.0914094580319 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  3.89763470197726 bayes_pls_golite062009
  • binding
    		•  3.85318710398432 bayes_pls_golite062009
  • protein binding
    		•  3.21524787168952 bayes_pls_golite062009
  • transcription factor binding
    		•  2.68044489404568 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.38308182853979 bayes_pls_golite062009
  • steroid hormone receptor activity
    		•  2.30195937604451 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.20686235000733 bayes_pls_golite062009
  • receptor activity
    		•  2.07573173722434 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.73827483890179 bayes_pls_golite062009
  • nuclear hormone receptor binding
    		•  1.60419100774741 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.34794228300778 bayes_pls_golite062009
  • retinoic acid receptor binding
    		•  1.28118886948947 bayes_pls_golite062009
  • transcription coactivator activity
    		•  1.23834725221597 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.19872119297817 bayes_pls_golite062009
  • signal transducer activity
    		•  1.19872119297817 bayes_pls_golite062009
  • retinoid X receptor binding
    		•  0.99801784942981 bayes_pls_golite062009
  • retinoic acid receptor activity
    		•  0.853869057774515 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.797229273848179 bayes_pls_golite062009
  • hormone receptor binding
    		•  0.74373733735458 bayes_pls_golite062009
  • promoter binding
    		•  0.58091332905515 bayes_pls_golite062009
  • protein N-terminus binding
    		•  0.57701453824007 bayes_pls_golite062009
  • thyroid hormone receptor activity
    		•  0.49784404390361 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.45265806678057 bayes_pls_golite062009
  • receptor binding
    		•  0.418843034756825 bayes_pls_golite062009
  • ligand-regulated transcription factor activity
    		•  0.202197503742221 bayes_pls_golite062009
  • lipid binding
    		•  0.164046651023989 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.15737167800277 bayes_pls_golite062009
  • catalytic activity
    		•  0.106902059021677 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.88

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle