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Protein Overview: niki-PA

General Information:
Name(s) found: niki-PA / FBpp0084112 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene nimA-like kinase is referred to in FlyBase by the symbol Dmel\niki (CG10951, FBgn0045980). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:20648123..20651105. It has the cytological map location 96A23-96A24. Based on sequence similarity, it is predicted to have molecular function</span>: receptor signaling protein serine/threonine kinase activity. It is reported to be involved in the biological process</span>: protein amino acid phosphorylation. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 841 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: protein amino acid phosphorylation [IEA][NAS]
    Molecular Function: ATP binding [IEA]
    receptor signaling protein serine/threonine kinase activity [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKKFRAKASS LPIFNGRITD ATTLTTSSLQ LPLGQNTQRK QSTCTRVLPT VFTITDGTTG  60
   61 AASTSLAEAM SSSKAQMPNR QESLLQLSVP RETGVGVAGP ELANYEKVRV VGQGSFGIAI 120
  121 LYRRKSDGHQ IVFKQINLSE LSPPGRDLAM NEVDVFSKLH HPNIVSYLGS FIKDNTLLIE 180
  181 MEYADGGTLA QIIAERQGKL HFPERYIIAV FEQISSAINY MHSENILHRD LKTANVFLNR 240
  241 RGIVKIGDFG ISKIMNTKIH AQTVLGTPYY FSPEMCEGKE YDNKSDIWAL GCILGEMCCL 300
  301 KKTFAASNLS ELVTKIMAGN YTPVPSGYTS GLRSLMSNLL QVEAPRRPTA SEVLVYWIPL 360
  361 IFRSLGKNKG YSYEDDVGGP GSDQLTAPVP AAAYSNVSME LELPTAQTET KQLMIADTAA 420
  421 PHEILEKRSV LYQLKAFGTC FSMAPIQLPP KAVIVDVAMS DSHFVVVNED GSAYAWGEGT 480
  481 HGQLGLTALE AWKHYPSRME SVRNYHVVSA CAGDGFTILV TQAGSLLSCG SNAHLALGQD 540
  541 EQRNYHSPKL IARLADVRVE QVAAGLQHVL ALSREGAVYV WGTSTCGALG LGNYQQQQKF 600
  601 PQKILLSHVK TKPSKIYCGP DTSAVLFANG ELHVCGSNDY NKLGFQRSAK ITAFKKVQLP 660
  661 HKVTQACFSS THSVFLVEGG YVYTMGRNAE GQRGIRHCNS VDHPTLVDSV KSRYIVKANC 720
  721 SDQCTIVASE DNIITVWGTR NGLPGIGSTN CGLGLQICTP NMELELGNNT AAFTNFLASV 780
  781 YKSELILEPV DILALFSSKE QCDRGYYVQV HDVYPLAHSV LVLVDTTTPL ISSYEGDYPH 840
  841 L

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..100] deduced N/A No confident structure predictions are available.
    2 View Details [101..370] PSI-BLAST 49.39794 No description for 2javA was found.
    3 View Details [371..470] FFAS03 3.73 Regulator of chromosome condensation RCC1
    4 View Details [471..841] PSI-BLAST 90.69897 Regulator of chromosome condensation RCC1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.04467222534257 bayes_pls_golite062009
  • kinase activity
    		•  4.85903980916957 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.63692708178478 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.26787750561728 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • tubulin binding
    		•  2.18641675163967 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.12615078788254 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • microtubule binding
    		•  1.88110801192607 bayes_pls_golite062009
  • telethonin binding
    		•  1.75733591474207 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • actin binding
    		•  1.33479685165255 bayes_pls_golite062009
  • gamma-tubulin binding
    		•  1.28511591054866 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • alpha-actinin binding
    		•  0.877087652539674 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.612883428421652 bayes_pls_golite062009
  • transporter activity
    		•  0.553953601841147 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.499492353295369 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.37676337669549 bayes_pls_golite062009
  • signal transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • actin filament binding
    		•  0.2403700250846 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.0611721261859464 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.0556163711947139 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.00652065412910241 bayes_pls_golite062009
    3 No functions predicted.
    4
    Term Confidence Notes
  • Ran guanyl-nucleotide exchange factor activity
    		•  1.99390987036621 bayes_pls_golite062009
  • binding
    		•  1.94765972306941 bayes_pls_golite062009
  • protein binding
    		•  1.61885402246805 bayes_pls_golite062009
  • GTPase regulator activity
    		•  1.59687876910551 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  1.57610576713427 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  1.52467418230017 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  1.49148933341823 bayes_pls_golite062009
  • Ras guanyl-nucleotide exchange factor activity
    		•  1.40097482342838 bayes_pls_golite062009
  • chromatin binding
    		•  1.1028187707197 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.09962825840688 bayes_pls_golite062009
  • histone binding
    		•  0.76536700536926 bayes_pls_golite062009
  • catalytic activity
    		•  0.261970921089142 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.62

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle